D609

Product Name: D609
CAS No.: 83373-60-8
Chemical Name: D609
Synonyms: D609;D609 ,98%;D609,D-609;D-609 POTASSIUM;D609 POTASSIUM SALT;D609 potassium salt,98%;Tricyclodecan-9-yl xanthate;Tricyclodecan-9-yl xanthogenate;tricyclodecane-9-yl-xanthogenate;TRICYCLODECAN-9-YL XANTHOGENATE K
CBNumber: CB9249743
Molecular Formula: C11H17KOS2
Formula Weight: 268.47
MOL File: 83373-60-8.mol

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D609 Property

storage temp.: 0-6°C
solubility: H₂O: 300 mg/mL
form: solid
color: off-white
Water Solubility: Soluble to 100 mM in water

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Safety

Risk Statements: 22
Safety Statements: 24/25
WGK Germany: 3
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T8543
Product name: O-Tricyclo[5.2.1.02,6]dec-9-yl dithiocarbonate potassium salt
Purity: ≥95%, solid
Packaging: 5mg
Price: $259
Updated: 2024/03/01

Sigma-Aldrich

Product number: 251400
Product name: D609, Potassium Salt
Packaging: 5mg
Price: $289
Updated: 2024/03/01

Cayman Chemical

Product number: 13307
Product name: D609 (potassium salt)
Purity: ≥90%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 13307
Product name: D609 (potassium salt)
Purity: ≥90%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Sigma-Aldrich

Product number: T8543
Product name: O-Tricyclo[5.2.1.02,6]dec-9-yl dithiocarbonate potassium salt
Purity: ≥95%, solid
Packaging: 25mg
Price: $1040
Updated: 2024/03/01

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D609 Chemical Properties,Usage,Production

Description

D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC; K_i = 6.4 μM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA₂, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively. Similar to other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities. In addition, it has anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes (IC₅₀ = 20 μg/ml) and IL-1β-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells.

Chemical Properties

white to off-white solid

Uses

D609 has been used as a phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor in mouse bone marrow derived monocytes. D609 has also been reported to significantly reduce the elevated levels of phosphatidylethanolamine binding protein 1 (PEBP1) in apolipoprotein E^-/- mice.

Biological Activity

Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (K i = 6.4 μ M); antiviral and antitumor agent. Suppresses LPS- and IFN γ -induced NO production (IC 50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo .

Biochem/physiol Actions

D609 can block the production of diacylglycerol (DAG) in the cell. D609 functions by inhibiting the phospholipase C-mediated hydrolysis of the phosphate bond present in phosphatidylcholine and other glycerophospholipids.

storage

Desiccate at -20°C

References

1. a) e. amtmann, drugs exp clin res 1996, 22, 287-294; b) r. m. adibhatla, j. f. hatcher and a. gusain, neurochem res 2012, 37, 671-679. 2. l. paris, s. cecchetti, f. spadaro, l. abalsamo, l. lugini, m. e. pisanu, e. iorio, p. g. natali, c. ramoni and f. podo, breast cancer res 2010, 12, r27. 3. a) k. tschaikowsky, m. meisner, f. schonhuber and e. rugheimer, br j pharmacol 1994, 113, 664-668; b) r. r. cobb, k. a. felts, g. c. parry and n. mackman, mol pharmacol 1996, 49, 998-1004.

D609 Preparation Products And Raw materials

Raw materials

Preparation Products

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D609 Suppliers

China 62 Germany 2 India 1 Japan 1 Switzerland 2 United Kingdom 2 United States 20 Global 90

MedChemexpress LLC

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Creative Enzymes

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MedChemExpress

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BIOMOL INTERNATIONAL, LP

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83373-60-8, D609Related Search:

CYCLOOCTANEMETHANOL ISOPROPYLXANTHIC ACID POTASSIUM SALT N-BUTYLXANTHIC ACID POTASSIUM SALT Potassium Amylxanthate POTASSIUM ISOAMYLXANTHATE Tetrahydrocyclopentadiene D609 potassium O-octyl dithiocarbonate Potassium ethylxanthate TS-609,flocculant TS-609 EINECS 203-609-1 Cyastat 609 caswellno60 Potassium O-Isobutyl Dithiocarbonate 2-CYCLOPENTYL CYCLOPENTANOL Potassium methylxanthate N-PROPYLXANTHIC ACID POTASSIUM SALT BICYCLO[2.2.1]HEPTAN-2-OL

TRICYCLODECAN-9-YL XANTHOGENATE K

TRICYCLODECAN-9-YL XANTHOGENATE POTASSIUM SALT

D609, Potassium Salt - CAS 83373-60-8 - Calbiochem

CARBONODITHIOIC ACID, O-(OCTAHYDRO-4,7-METHANO-1H-INDEN-5-YL) ESTER POTASSIUM

D609

D-609 POTASSIUM

D609 POTASSIUM SALT

O-TRICYCLO[5.2.1.0(2,6)]DEC-9-YL DITHIOCARBONATE POTASSIUM SALT

O-(OCTAHYDRO-4,7-METHANO-1H-INDEN-5-YL) CARBONOPOTASSIUM DITHIOATE

potassium O-(octahydro-4,7-methano-1H-inden-5-yl) dithiocarbonate

O-TRICYCLO(5.2.1.02,6)DEC-9-YL*DITHIOCAR BONATE POTA

Dithiocarbonic acid O-[(octahydro-4,7-methano-1H-inden)-5-yl]S-potassium salt

Tricyclodecan-9-yl xanthate

Tricyclodecan-9-yl xanthate potassium salt

Tricyclodecan-9-yl xanthogenate

D609 potassium salt,98%

Carbonodithioic acid O-(octahydro-4,7-methano-1H-inden-5-yl) ester potassium salt

tricyclodecane-9-yl-xanthogenate

D609 ,98%

CARBONODITHIOIC ACID, O-(OCTAHYDRO-4,7-METH

O-Tricyclo[5.2.1.02,6]dec-9-yl dithiocarbonate

D609,O-(Octahydro-4,7-methano-1H-inden-5-yl)carbonopotassiumdithioate

potassium O-(octahydro-1H-4,7-methanoinden-5-yl) carbonodithioate

D609,D-609

83373-60-8

C11H15KOS2

Biochemicals and Reagents

BioChemical

P to Q

Phospholipase C, phosphatidylcholine-specific

Enzyme Inhibitors by Enzyme

Enzyme Inhibitors

Enzymes, Inhibitors, and Substrates

Lipid signaling