N-(1,3,4-Thiadiazolyl)nicotinamide

Product Name: N-(1,3,4-Thiadiazolyl)nicotinamide
CAS No.: 51987-99-6
Chemical Name: N-(1,3,4-Thiadiazolyl)nicotinamide
Synonyms: TGN-020;Nicotinamide Impurity 156;TGN 020;TGN-020;TGN020;51987-99-6;2-(Nicotinamide)-1,3,4-thiadiazole;N-(1,3,4-Thiadiazolyl)nicotinamide;N-(1,3,4-Thiadiazolyl)-m-nicotinamide;N-(1,3,4-Thiadiazol-2-yl)nicotinamide;TGN-020:2-(Nicotinamide)-1,3,4-thiadiazole;N-(1,3,4-Thiadiazol-2-yl)pyridine-3-carboxamide;N-(1,3,4-Thiadiazol-2-yl)-3-pyridinecarboxamide
CBNumber: CB92511583
Molecular Formula: C8H6N4OS
Formula Weight: 206.22
MOL File: 51987-99-6.mol

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N-(1,3,4-Thiadiazolyl)nicotinamide Property

Melting point:: 291-293°C
Density: 1.500±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: ≥8mg/mL
pka: 6.78±0.50(Predicted)
form: powder
color: white to tan
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0136
Product name: TGN-020
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $148
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0136
Product name: TGN-020
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $588
Updated: 2024/03/01

Tocris

Product number: 5425
Product name: TGN020
Purity: ≥99%(HPLC)
Packaging: 50
Price: $487
Updated: 2021/12/16

Tocris

Product number: 5425
Product name: TGN020
Purity: ≥99%(HPLC)
Packaging: 10
Price: $115
Updated: 2021/12/16

TRC

Product number: T344000
Product name: N-(1,3,4-Thiadiazolyl)nicotinamide
Packaging: 25mg
Price: $95
Updated: 2021/12/16

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N-(1,3,4-Thiadiazolyl)nicotinamide Chemical Properties,Usage,Production

Description

TGN-020 (51987-99-6) is an aquaporin 4 channel blocker, IC50?= 3.1 μM.1?Reduces ischemic cerebral edema in a mouse model of focal cerebral ischemia using MRI.2?TGN-020 increases regional cerebral blood flow as determined in wild-type and AQP-4 knockout mice.3? Reduces brain edema when administered after onset of ischemia in rat models.4

Chemical Properties

Off-White Solid

Uses

A thiadiazole derivative as antitumor agent.

Biochem/physiol Actions

TGN-020 is an inhibitor of Aquaporin 4 (AQP4), the most abundant water channel in brain. Aquaporins (AQPs) are water channels required for maintaining fluid homeostasis and enabling water movement across barrier membranes, but can enhance pathological cellular volume changes and cause edema in injury states. Pretreatment with the AQP4 inhibitor TGN-020 significantly reduced the volume of brain edema associated with ischemic injury in a mouse model of focal cerebral ischemia.

storage

Store at RT

References

1) Huber?et al. (2009), Identification of aquaporin 4 inhibitors using in vitro and in silico methods; Bioorg. Med. Chem.,?17?411 2) Igarashi?et al. (2011),?Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema; Neurol. Sci.,?32?113 3) Igarashi?et al. (2013),?Inhibition of aquaporin-4 significantly increases regional cerebral blood flow; Infect. Neuroreport,?24?324 4) Pirici?et al.?(2017),?Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways; Int. J. Mol. Sci.,?19?E46

N-(1,3,4-Thiadiazolyl)nicotinamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(1,3,4-Thiadiazolyl)nicotinamide Suppliers

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N-(1,3,4-Thiadiazolyl)nicotinamide

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N-(1,3,4-Thiadiazol-2-yl)pyridine-3-carboxamide

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N-(1,3,4-Thiadiazol-2-yl)nicotinamide

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scar,edema,glial,Inhibitor,TGN 020,AQP4,Aquaporin 4,inhibit,PROTAC Linkers,TGN-020

Nicotinamide Impurity 156

51987-99-6

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