3-Bromo-4-methyl-5-nitropyridine

Product Name: 3-Bromo-4-methyl-5-nitropyridine
CAS No.: 69872-15-7
Chemical Name: 3-Bromo-4-methyl-5-nitropyridine
Synonyms: 3-Bromo-4-methy-5nitro-pyridine;3-Bromo-4-methyl-5-nitropyridine;4-Methyl-5-Bromo-3-Nitropyridine;Pyridine, 3-bromo-4-methyl-5-nitro-;3-Bromo-4-methyl-5-nitropyridine ISO 9001：2015 REACH
CBNumber: CB92516230
Molecular Formula: C6H5BrN2O2
Formula Weight: 217.02
MOL File: 69872-15-7.mol

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3-Bromo-4-methyl-5-nitropyridine Property

Melting point:: 57-58℃
Boiling point:: 269℃
Density: 1.709
Flash point:: 116℃
storage temp.: Sealed in dry,Room Temperature
pka: -0.51±0.28(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C6H5BrN2O2/c1-4-5(7)2-8-3-6(4)9(10)11/h2-3H,1H3
InChIKey: WFCIQRPATFRBOY-UHFFFAOYSA-N
SMILES: C1=NC=C([N+]([O-])=O)C(C)=C1Br

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B808055
Product name: 3-Bromo-4-methyl-5-nitropyridine
Packaging: 500mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143819
Product name: 3-Bromo-4-methyl-5-nitropyridine
Packaging: 5G
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-W003806
Product name: 3-Bromo-4-methyl-5-nitropyridine
Purity: 97.61%
Packaging: 25g
Price: $295
Updated: 2021/12/16

Matrix Scientific

Product number: 076300
Product name: 3-Bromo-4-methyl-5-nitropyridine
Purity: 95+%
Packaging: 5g
Price: $373
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143819
Product name: 3-Bromo-4-methyl-5-nitropyridine
Packaging: 10g
Price: $400
Updated: 2021/12/16

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3-Bromo-4-methyl-5-nitropyridine Chemical Properties,Usage,Production

Uses

3-Bromo-4-methyl-5-nitropyridine is an intermediate used in the synthesis of 4-bromo-6-azaindole and other azaindole derivatives.

Synthesis

31872-63-6

105-53-3

69872-15-7

GENERAL STEPS: Diethyl malonate (3.84 mL, 25.3 mmol) was slowly added dropwise to a suspension of sodium hydride (1.01 g, 60% oil suspension, 25.3 mmol) in DMF (15 mL) at 0 °C and stirred for 30 min until gas escape ceased. Subsequently, 3-bromo-4-chloro-5-nitropyridine (3.00 g, 12.6 mmol) was slowly added and the resulting dark reddish brown solution was stirred for 1 hour at room temperature. Upon completion of the reaction, it was carefully quenched with water and the pH was adjusted to 1 with 1 N HCl. The aqueous phase was extracted with EtOAc (2 x 150 mL), the organic phases were combined and washed with deionized water (100 mL) and saturated saline, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was dissolved in 4N HCl (50 mL) and refluxed for 16 hours. The reaction mixture was cooled in an ice bath and neutralized with 50% NaOH solution to pH 7. The aqueous phase was again extracted with EtOAc (3 x 100 mL), the organic phases were combined and washed with saturated saline, dried over MgSO4, filtered and concentrated under reduced pressure to afford the target product 3-bromo-4-methyl-5-nitropyridine (94a, 1.90 g, 70% yield) as a yellow solid. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 8.94 (s, 1H), 8.97 (s, 1H), 2.65 (s, 3H).

References

[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2462 - 2471
[2] Patent: US2005/90529, 2005, A1. Location in patent: Page/Page column 82

3-Bromo-4-methyl-5-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-4-methyl-5-nitropyridine Suppliers

China 113 India 7 United Kingdom 1 United States 9 Global 130

Shanghai Helai Biotech Co. Ltd.

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View Lastest Price from 3-Bromo-4-methyl-5-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Bromo-4-methyl-5-nitropyridine 69872-15-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-07-10

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Bromo-4-methyl-5-nitropyridine 69872-15-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-05-20

Dideu Industries Group Limited

Product: 3-Bromo-4-methyl-5-nitropyridine 69872-15-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-22

69872-15-7, 3-Bromo-4-methyl-5-nitropyridineRelated Search:

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3-Bromo-4-methyl-5-nitropyridine

3-Bromo-4-methy-5nitro-pyridine

Pyridine, 3-bromo-4-methyl-5-nitro-

3-Bromo-4-methyl-5-nitropyridine ISO 9001：2015 REACH

4-Methyl-5-Bromo-3-Nitropyridine

69872-15-7

Heterocycle-Pyridine series