3-Bromo-4-methyl-5-nitropyridine
- Product Name
- 3-Bromo-4-methyl-5-nitropyridine
- CAS No.
- 69872-15-7
- Chemical Name
- 3-Bromo-4-methyl-5-nitropyridine
- Synonyms
- 3-Bromo-4-methy-5nitro-pyridine;3-Bromo-4-methyl-5-nitropyridine;4-Methyl-5-Bromo-3-Nitropyridine;Pyridine, 3-bromo-4-methyl-5-nitro-;3-Bromo-4-methyl-5-nitropyridine ISO 9001：2015 REACH
- CBNumber
- CB92516230
- Molecular Formula
- C6H5BrN2O2
- Formula Weight
- 217.02
- MOL File
- 69872-15-7.mol
3-Bromo-4-methyl-5-nitropyridine Property
- Melting point:
- 57-58℃
- Boiling point:
- 269℃
- Density
- 1.709
- Flash point:
- 116℃
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -0.51±0.28(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C6H5BrN2O2/c1-4-5(7)2-8-3-6(4)9(10)11/h2-3H,1H3
- InChIKey
- WFCIQRPATFRBOY-UHFFFAOYSA-N
- SMILES
- C1=NC=C([N+]([O-])=O)C(C)=C1Br
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B808055
- Product name
- 3-Bromo-4-methyl-5-nitropyridine
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FB143819
- Product name
- 3-Bromo-4-methyl-5-nitropyridine
- Packaging
- 5G
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-W003806
- Product name
- 3-Bromo-4-methyl-5-nitropyridine
- Purity
- 97.61%
- Packaging
- 25g
- Price
- $295
- Updated
- 2021/12/16
- Product number
- 076300
- Product name
- 3-Bromo-4-methyl-5-nitropyridine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $373
- Updated
- 2021/12/16
- Product number
- FB143819
- Product name
- 3-Bromo-4-methyl-5-nitropyridine
- Packaging
- 10g
- Price
- $400
- Updated
- 2021/12/16
3-Bromo-4-methyl-5-nitropyridine Chemical Properties,Usage,Production
Uses
3-Bromo-4-methyl-5-nitropyridine is an intermediate used in the synthesis of 4-bromo-6-azaindole and other azaindole derivatives.
Synthesis
31872-63-6
105-53-3
69872-15-7
GENERAL STEPS: Diethyl malonate (3.84 mL, 25.3 mmol) was slowly added dropwise to a suspension of sodium hydride (1.01 g, 60% oil suspension, 25.3 mmol) in DMF (15 mL) at 0 °C and stirred for 30 min until gas escape ceased. Subsequently, 3-bromo-4-chloro-5-nitropyridine (3.00 g, 12.6 mmol) was slowly added and the resulting dark reddish brown solution was stirred for 1 hour at room temperature. Upon completion of the reaction, it was carefully quenched with water and the pH was adjusted to 1 with 1 N HCl. The aqueous phase was extracted with EtOAc (2 x 150 mL), the organic phases were combined and washed with deionized water (100 mL) and saturated saline, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was dissolved in 4N HCl (50 mL) and refluxed for 16 hours. The reaction mixture was cooled in an ice bath and neutralized with 50% NaOH solution to pH 7. The aqueous phase was again extracted with EtOAc (3 x 100 mL), the organic phases were combined and washed with saturated saline, dried over MgSO4, filtered and concentrated under reduced pressure to afford the target product 3-bromo-4-methyl-5-nitropyridine (94a, 1.90 g, 70% yield) as a yellow solid. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 8.94 (s, 1H), 8.97 (s, 1H), 2.65 (s, 3H).
References
[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2462 - 2471
[2] Patent: US2005/90529, 2005, A1. Location in patent: Page/Page column 82
3-Bromo-4-methyl-5-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Bromo-4-methyl-5-nitropyridine manufacturers
- Product
- 3-Bromo-4-methyl-5-nitropyridine 69872-15-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-10
- Product
- 3-Bromo-4-methyl-5-nitropyridine 69872-15-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-20
- Product
- 3-Bromo-4-methyl-5-nitropyridine 69872-15-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-22