Tubulysin A,TubA
- Product Name
- Tubulysin A,TubA
- CAS No.
- 205304-86-5
- Chemical Name
- Tubulysin A,TubA
- Synonyms
- TubA;CS-1324;Tubulysin A;Tubulysins A;Tubulysin A,TubA;(2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoicaci;Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(3-methyl-1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-
- CBNumber
- CB92518395
- Molecular Formula
- C43H65N5O10S
- Formula Weight
- 844.07
- MOL File
- 205304-86-5.mol
Tubulysin A,TubA Property
- Melting point:
- 106-108 °C(Solv: methanol (67-56-1); water (7732-18-5))
- Boiling point:
- 979.9±65.0 °C(Predicted)
- Density
- 1.195±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- organic solvents: soluble
- form
- film
- pka
- 4.52±0.23(Predicted)
- color
- colorless or white
Safety
- Hazard Codes
- T
- Risk Statements
- 23/24/25-36/37/38
- Safety Statements
- 36/37-45
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P311Call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- T897135
- Product name
- TubulysinA
- Packaging
- 0.25mg
- Price
- $385
- Updated
- 2021/12/16
- Product number
- T897135
- Product name
- TubulysinA
- Packaging
- 1mg
- Price
- $1405
- Updated
- 2021/12/16
- Product number
- T897135
- Product name
- TubulysinA
- Packaging
- 2.5mg
- Price
- $2805
- Updated
- 2021/12/16
- Product number
- T897135
- Product name
- TubulysinA
- Packaging
- 5mg
- Price
- $4235
- Updated
- 2021/12/16
- Product number
- PEP0004574
- Product name
- TUBULYSIN A
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $2684.85
- Updated
- 2021/12/16
Tubulysin A,TubA Chemical Properties,Usage,Production
Uses
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative.
Definition
ChEBI: Tubulysin A is a diester and a carboxylic acid.
Biochem/physiol Actions
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.
Tubulysin A,TubA Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Tubulysin A,TubA manufacturers
- Product
- Tubulysin A,TubA 205304-86-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2019-12-25