CP466722

ChemicalBook > CAS DataBase List > CP466722

Product Name: CP466722
CAS No.: 1080622-86-1
Chemical Name: CP466722
Synonyms: CS-73;CP466722;CP-466722, >98%;CP-466722;CP466722;CP466722 USP/EP/BP;CP466722 >=98% (HPLC);CP466722;CP 466722;CP-466722;2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine;1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine
CBNumber: CB92535567
Molecular Formula: C17H15N7O2
Formula Weight: 349.35
MOL File: 1080622-86-1.mol

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CP466722 Property

Boiling point:: 642.3±65.0 °C(Predicted)
Density: 1.48
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO: soluble0.5mg/mL, clear (warmed)
pka: 0.00±0.19(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1115
Product name: CP466722
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $212
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML1115
Product name: CP466722
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $724
Updated: 2022/05/15

Cayman Chemical

Product number: 25417
Product name: CP 466,722
Purity: ≥98%
Packaging: 1mg
Price: $41
Updated: 2024/03/01

Cayman Chemical

Product number: 25417
Product name: CP 466,722
Purity: ≥98%
Packaging: 5mg
Price: $183
Updated: 2024/03/01

Cayman Chemical

Product number: 25417
Product name: CP 466,722
Purity: ≥98%
Packaging: 10mg
Price: $322
Updated: 2024/03/01

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CP466722 Chemical Properties,Usage,Production

Description

CP 466,722 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase that inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of the ATM targets SMC1, Chk2, and p53 in HeLa cells when used at a concentration of 10 μM. It is selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively. CP 466,722 decreases cell survival in response to ionizing radiation in HeLa cells. It is also cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC₅₀s = 16.92 and 12.78 μM, respectively).

Uses

CP466722 is a competetive, reversible inhbitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase

Definition

ChEBI: 2-(6,7-dimethoxy-4-quinazolinyl)-5-(2-pyridinyl)-1,2,4-triazol-3-amine is a member of quinazolines.

target

ATM

References

[1]. guo, k., et al., development of a cell-based, high-throughput screening assay for atm kinase inhibitors. j biomol screen, 2014. 19(4): p. 538-46.
[2]. nadkarni, a., et al., atm inhibitor ku-55933 increases the tmz responsiveness of only inherently tmz sensitive gbm cells. j neurooncol, 2012. 110(3): p. 349-57.
[3]. rainey, m.d., et al., transient inhibition of atm kinase is sufficient to enhance cellular sensitivity to ionizing radiation. cancer res, 2008. 68(18): p. 7466-74.

CP466722 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CP466722 manufacturers

Career Henan Chemical Co

Product: CP466722;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine 1080622-86-1
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

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CP466722

1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine

CP466722;CP 466722;CP-466722

CS-73

CP-466722, >98%

2-(6,7-dimethoxyquinazolin-4-yl)-5-(pyridin-2-yl)-2H-1,2,4-triazol-3-amine

1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine CP 466722

2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine

CP-466722;CP466722

1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine

1H-1,2,4-Triazol-5-amine, 1-(6,7-dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-

CP466722 >=98% (HPLC)

CP466722 USP/EP/BP

1080622-86-1

C17H15N7O2

Inhibitors