CP466722
- Product Name
- CP466722
- CAS No.
- 1080622-86-1
- Chemical Name
- CP466722
- Synonyms
- CS-73;CP466722;CP-466722, >98%;CP-466722;CP466722;CP466722 USP/EP/BP;CP466722 >=98% (HPLC);CP466722;CP 466722;CP-466722;2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine;1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine
- CBNumber
- CB92535567
- Molecular Formula
- C17H15N7O2
- Formula Weight
- 349.35
- MOL File
- 1080622-86-1.mol
CP466722 Property
- Boiling point:
- 642.3±65.0 °C(Predicted)
- Density
- 1.48
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO: soluble0.5mg/mL, clear (warmed)
- pka
- 0.00±0.19(Predicted)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1115
- Product name
- CP466722
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $212
- Updated
- 2022/05/15
- Product number
- SML1115
- Product name
- CP466722
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $724
- Updated
- 2022/05/15
- Product number
- 25417
- Product name
- CP 466,722
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $41
- Updated
- 2024/03/01
- Product number
- 25417
- Product name
- CP 466,722
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $183
- Updated
- 2024/03/01
- Product number
- 25417
- Product name
- CP 466,722
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $322
- Updated
- 2024/03/01
CP466722 Chemical Properties,Usage,Production
Description
CP 466,722 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase that inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of the ATM targets SMC1, Chk2, and p53 in HeLa cells when used at a concentration of 10 μM. It is selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively. CP 466,722 decreases cell survival in response to ionizing radiation in HeLa cells. It is also cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC50s = 16.92 and 12.78 μM, respectively).
Uses
CP466722 is a competetive, reversible inhbitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase
Definition
ChEBI: 2-(6,7-dimethoxy-4-quinazolinyl)-5-(2-pyridinyl)-1,2,4-triazol-3-amine is a member of quinazolines.
target
ATM
References
[1]. guo, k., et al., development of a cell-based, high-throughput screening assay for atm kinase inhibitors. j biomol screen, 2014. 19(4): p. 538-46.
[2]. nadkarni, a., et al., atm inhibitor ku-55933 increases the tmz responsiveness of only inherently tmz sensitive gbm cells. j neurooncol, 2012. 110(3): p. 349-57.
[3]. rainey, m.d., et al., transient inhibition of atm kinase is sufficient to enhance cellular sensitivity to ionizing radiation. cancer res, 2008. 68(18): p. 7466-74.
CP466722 Preparation Products And Raw materials
Raw materials
Preparation Products
CP466722 Suppliers
- Tel
- --
- Fax
- --
- sales@alsachim.com
- Country
- France
- ProdList
- 424
- Advantage
- 0
View Lastest Price from CP466722 manufacturers
- Product
- CP466722;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine 1080622-86-1
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 95%~99%
- Supply Ability
- per week:100kg
- Release date
- 2019-09-05