Saxagliptin hydrate
- Product Name
- Saxagliptin hydrate
- CAS No.
- 945667-22-1
- Chemical Name
- Saxagliptin hydrate
- Synonyms
- CS-1180;Onglyza hydrate;BMS477118 hydrate;BMS-477118 hydrate;BMS 477118 hydrate;Saxagliptin hydrate;Shagliptin monohydrate;Saxagliptin hydrate Unii-9gb927lajw;Saxagliptin hydrate (BMS-477118 hydrate);BMS-477118 HYDRATE;BMS 477118 HYDRATE;BMS477118 HYDRATE
- CBNumber
- CB92542796
- Molecular Formula
- C18H27N3O3
- Formula Weight
- 333.43
- MOL File
- 945667-22-1.mol
Saxagliptin hydrate Property
- Melting point:
- 106-108°C
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Sparingly)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S143750
- Product name
- SaxagliptinHydrate
- Packaging
- 500mg
- Price
- $525
- Updated
- 2021/12/16
- Product number
- P000018464
- Product name
- Saxagliptin hydrate
- Purity
- 99+%
- Packaging
- 5mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FS44431
- Product name
- Saxagliptin monohydrate
- Packaging
- 10mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- P000018464
- Product name
- Saxagliptin hydrate
- Purity
- 99+%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- P000018464
- Product name
- Saxagliptin hydrate
- Purity
- 99+%
- Packaging
- 25mg
- Price
- $205
- Updated
- 2021/12/16
Saxagliptin hydrate Chemical Properties,Usage,Production
Description
While liraglutide targets the incretin system as a GLP-1 analog for
therapeutic intervention in T2DM, saxagliptin enhances GLP-1 plasma concentrations by inhibiting the DPP-4 enzyme responsible for degradation of
GLP-1 by cleavage of the two N-terminal amino acids adjacent to alanine (or
proline), thereby rendering the hormone inactive.
Similarto vildagliptin,
saxagliptin is a cyanopyrrolidine substrate-based inhibitor. The proline
mimetic occupies the small S1-pocket while the nitrile’s trajectory aligns
with the scissile bond of the substrate. The slow dissociation kinetics of
saxagliptin is attributed to a reversible, covalent reaction between the nitrile
and the catalytically active serine hydroxyl (Ser630).
The steric bulk provided by the adamantyl moiety and the constrained cyclopropyl ring stabilizes the trans-rotamer of the amide, thereby preventing the problematic
intramolecular cyclization, via the amino group attacking the nitrile, which
is favored in the cis-conformation.
Since metabolism of saxagliptin is primarily mediated by CYP3A4/5, there is a potential for drug interactions with concomitant administration of strong inducers or inhibitors of these cytochrome P450 enzymes. The most common adverse events (>5% of patients) included upper respiratory tract infection, urinary tract infection, and headache.
Originator
Bristol-Myers-Squibb (US)
Uses
Saxagliptin Hydrate is a selective and reversible dipeptidyl peptidase-4 (DPP4) inhibitor that may be used to develop treatment for type 2 diabetes.
Definition
ChEBI: Saxagliptin hydrate is a hydrate that is the monohydrate form of anhydrous saxagliptin. Used for the treatment of Type II diabetes. It has a role as a hypoglycemic agent and an EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor. It contains a saxagliptin.
brand name
Onglyza
Biological Activity
Saxagliptin (BMS-477118) is an orally active, highly potent and long-acting dipeptidyl peptidase IV inhibitor (human DPP-IV Ki = 0.9 nM; plasma DDP-IV inhibition = 87% 0.5-4h post 4 μmol/kg po. in normal rats) with therapeutic efficacy against type 2 diabetes in vivo (plasma glucose clearance = 28/43/61% post 0.3/1.0/3.0 μmol/kg po. in Zucker fa/fa rats).
Solubility in organics
Saxagliptin hydrochloride is supplied as a crystalline solid. A stock solution may be made by dissolving the saxagliptin (hydrochloride)in the solvent of choice,which should be purged with an inert gas. Saxagliptin hydrochloride is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). The solubility of saxagliptin hydrochloride in these solvents is approximately 10 mg/ml in ethanol and 20 mg/ml in DMSO and DMF. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of saxagliptin(hydrochloride)can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of saxagliptin (hydrochloride)in PBS(pH 7.2), is approximately 2 mg/ml. We do not recommend storing the aqueous solution for more than one day.
Saxagliptin hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Saxagliptin hydrate Suppliers
- Tel
- 18019964904; 17756579152
- Fax
- QQ:252833506
- liuchun.0228@163.com
- Country
- China
- ProdList
- 48
- Advantage
- 58
- Tel
- 15005178685; 15005178685
- 1347015058@qq.com
- Country
- China
- ProdList
- 91
- Advantage
- 58
- Tel
- 400-880-2824 18107960669
- Fax
- 18140514863
- 79046690@qq.com
- Country
- China
- ProdList
- 1267
- Advantage
- 58
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6005
- Advantage
- 61
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9809
- Advantage
- 59
- Tel
- 13327700685
- Fax
- +86-25-58744115
- sales@vcarepharmatech.com
- Country
- China
- ProdList
- 310
- Advantage
- 61
- Tel
- 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8842
- Advantage
- 52
- Tel
- 0512-65218020; 18261037325
- ivy.shen@pharmsyn.com
- Country
- China
- ProdList
- 101
- Advantage
- 60
- Tel
- 010-56645598 13366904824
- Fax
- 01062230033
- bjkaida@163.com
- Country
- China
- ProdList
- 1637
- Advantage
- 59
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
- Fax
- +86-27-87599188
- Country
- China
- ProdList
- 1493
- Advantage
- 55
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4428
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3120
- Advantage
- 55
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- 422131432@qq.com
- Country
- China
- ProdList
- 9978
- Advantage
- 55
- Tel
- 0523-18601685-898 18652728585
- sales@allyrise.com
- Country
- China
- ProdList
- 2773
- Advantage
- 60
- Tel
- 0576-88827176 18906581668
- Fax
- 86- 576 88822496
- sonya@creatingchemical.com
- Country
- China
- ProdList
- 130
- Advantage
- 64
- Tel
- 0512-87182056 18013166090
- Fax
- 0512-87182056
- lingling.qi@yacoo.com.cn
- Country
- China
- ProdList
- 7295
- Advantage
- 60
- Tel
- 027-59262863 13277907145 3091977954
- Fax
- 027-59420980
- Country
- China
- ProdList
- 4943
- Advantage
- 58
- Tel
- 0571-+86-571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 11481
- Advantage
- 59
- Tel
- 86-021-61559134 15921386130
- Fax
- 021-55068248
- 3423497944@qq.com
- Country
- China
- ProdList
- 8144
- Advantage
- 55
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- Fax
- -
- xg01_gj@163.com
- Country
- China
- ProdList
- 9484
- Advantage
- 50
- Tel
- 025-66023220 0086-15250997978
- Fax
- 025-58362220
- 1511893459@qq.com
- Country
- China
- ProdList
- 7850
- Advantage
- 55
- Tel
- 13656237714 13656237714
- Fax
- 0512-65852853
- xiaokunfu@kyyykj.com
- Country
- China
- ProdList
- 293
- Advantage
- 55
- Tel
- 021-38751876 15000076078
- Fax
- 021-50275764
- Info@rochipharma.com
- Country
- China
- ProdList
- 568
- Advantage
- 55
- Tel
- 028-86040038 13980902949;
- Fax
- 028-85149890
- market@dingdangchem.com
- Country
- China
- ProdList
- 1843
- Advantage
- 55
- Tel
- +86-400-851-9921
- Fax
- +86-10-82826195
- sales@pharmacodia.com
- Country
- China
- ProdList
- 2317
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 27313
- Advantage
- 60
- Tel
- 0317-5296180 15533709196
- Fax
- 0317-5106596
- sale@enkepharma.com
- Country
- China
- ProdList
- 1898
- Advantage
- 55
- Tel
- sales@njromanme.com
- Country
- China
- ProdList
- 4529
- Advantage
- 58
- Tel
- 021-2022843681 15618226720
- Fax
- +86-21-51601218
- lucy@atkchemical.com
- Country
- China
- ProdList
- 10267
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 027-59402396 13419635609
- Fax
- 027-83989310
- 13419635609@163.com
- Country
- China
- ProdList
- 1977
- Advantage
- 55
- Tel
- 027-83778876 13667159345
- Fax
- 027-83778876
- 13667159345@163.com
- Country
- China
- ProdList
- 1990
- Advantage
- 55
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- 18066080842 13952020641
- Fax
- 025-58912720
- bamd@foxmail.com
- Country
- China
- ProdList
- 712
- Advantage
- 55
- Tel
- 17836913271
- Fax
- 0374-8348899
- 3224305243@qq.com
- Country
- China
- ProdList
- 2925
- Advantage
- 58
- Tel
- 027-027-83778875 15807197853
- Fax
- 027-83991220
- 15807197853@163.com
- Country
- China
- ProdList
- 4014
- Advantage
- 58
- Tel
- 021-58180488
- Fax
- 021-58180499
- sales@Medchemleader.com
- Country
- China
- ProdList
- 1005
- Advantage
- 58
- Tel
- 13715524166 13326948089
- Fax
- +86 760 8866 5202
- resicn@resicn.com
- Country
- China
- ProdList
- 520
- Advantage
- 58
- Tel
- 027-83778895 18602735115
- Fax
- 027-51119224
- 18602735115@163.com
- Country
- China
- ProdList
- 1993
- Advantage
- 64
- Tel
- 021-60345187 13917602471
- Fax
- 021-60345187
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 9897
- Advantage
- 58
- Tel
- 021-57951555
- Fax
- 021-57951555
- tianshihuagong1111@163.com
- Country
- CHINA
- ProdList
- 1356
- Advantage
- 58
- Tel
- 15502154572
- Fax
- -
- yuben012@sina.com
- Country
- China
- ProdList
- 508
- Advantage
- 58
- Tel
- 027-51831887 15337167856
- Fax
- 027-51837635 QQ1165326703
- hubeixinyuanshun@163.com
- Country
- China
- ProdList
- 10295
- Advantage
- 58
- Tel
- 13382066392
- Country
- CHINA
- ProdList
- 4877
- Advantage
- 58
- Tel
- 0371-037163312495,13303845143 13303845143
- Fax
- QQ3001379618
- 3001379618@qq.com
- Country
- China
- ProdList
- 10002
- Advantage
- 58
- Tel
- 010-82387566 18001021521;
- Fax
- 82387566-801
- sales@mreda.com.cn
- Country
- China
- ProdList
- 10789
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4696
- Advantage
- 58
View Lastest Price from Saxagliptin hydrate manufacturers
- Product
- Saxagliptin hydrate 945667-22-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22
- Product
- Saxagliptin hydrate 945667-22-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Saxagliptin hydrate 945667-22-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08