Saxagliptin hydrate

Product Name: Saxagliptin hydrate
CAS No.: 945667-22-1
Chemical Name: Saxagliptin hydrate
Synonyms: CS-1180;Onglyza hydrate;BMS477118 hydrate;BMS-477118 hydrate;BMS 477118 hydrate;Saxagliptin hydrate;Shagliptin monohydrate;Saxagliptin hydrate Unii-9gb927lajw;Saxagliptin hydrate (BMS-477118 hydrate);BMS-477118 HYDRATE;BMS 477118 HYDRATE;BMS477118 HYDRATE
CBNumber: CB92542796
Molecular Formula: C18H27N3O3
Formula Weight: 333.43
MOL File: 945667-22-1.mol

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Saxagliptin hydrate Property

Melting point:: 106-108°C
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Sparingly)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: S143750
Product name: SaxagliptinHydrate
Packaging: 500mg
Price: $525
Updated: 2021/12/16

Ark Pharm

Product number: P000018464
Product name: Saxagliptin hydrate
Purity: 99+%
Packaging: 100mg
Price: $567
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611536
Product name: Saxagliptin hydrate
Packaging: 250mg
Price: $615.4
Updated: 2021/12/16

Ark Pharm

Product number: P000018464
Product name: Saxagliptin hydrate
Purity: 99+%
Packaging: 50mg
Price: $349
Updated: 2021/12/16

AK Scientific

Product number: Z6180
Product name: Saxagliptinhydrate
Packaging: 50mg
Price: $385
Updated: 2021/12/16

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Saxagliptin hydrate Chemical Properties,Usage,Production

Description

While liraglutide targets the incretin system as a GLP-1 analog for therapeutic intervention in T2DM, saxagliptin enhances GLP-1 plasma concentrations by inhibiting the DPP-4 enzyme responsible for degradation of GLP-1 by cleavage of the two N-terminal amino acids adjacent to alanine (or proline), thereby rendering the hormone inactive. Similarto vildagliptin, saxagliptin is a cyanopyrrolidine substrate-based inhibitor. The proline mimetic occupies the small S1-pocket while the nitrile’s trajectory aligns with the scissile bond of the substrate. The slow dissociation kinetics of saxagliptin is attributed to a reversible, covalent reaction between the nitrile and the catalytically active serine hydroxyl (Ser630). The steric bulk provided by the adamantyl moiety and the constrained cyclopropyl ring stabilizes the trans-rotamer of the amide, thereby preventing the problematic intramolecular cyclization, via the amino group attacking the nitrile, which is favored in the cis-conformation.
Since metabolism of saxagliptin is primarily mediated by CYP3A4/5, there is a potential for drug interactions with concomitant administration of strong inducers or inhibitors of these cytochrome P450 enzymes. The most common adverse events (>5% of patients) included upper respiratory tract infection, urinary tract infection, and headache.

Originator

Bristol-Myers-Squibb (US)

Uses

Saxagliptin Hydrate is a selective and reversible dipeptidyl peptidase-4 (DPP4) inhibitor that may be used to develop treatment for type 2 diabetes.

Definition

ChEBI: Saxagliptin hydrate is a hydrate that is the monohydrate form of anhydrous saxagliptin. Used for the treatment of Type II diabetes. It has a role as a hypoglycemic agent and an EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor. It contains a saxagliptin.

brand name

Onglyza

Biological Activity

Saxagliptin (BMS-477118) is an orally active, highly potent and long-acting dipeptidyl peptidase IV inhibitor (human DPP-IV Ki = 0.9 nM; plasma DDP-IV inhibition = 87% 0.5-4h post 4 μmol/kg po. in normal rats) with therapeutic efficacy against type 2 diabetes in vivo (plasma glucose clearance = 28/43/61% post 0.3/1.0/3.0 μmol/kg po. in Zucker fa/fa rats).

Solubility in organics

Saxagliptin hydrochloride is supplied as a crystalline solid. A stock solution may be made by dissolving the saxagliptin (hydrochloride)in the solvent of choice,which should be purged with an inert gas. Saxagliptin hydrochloride is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). The solubility of saxagliptin hydrochloride in these solvents is approximately 10 mg/ml in ethanol and 20 mg/ml in DMSO and DMF. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of saxagliptin(hydrochloride)can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of saxagliptin (hydrochloride)in PBS(pH 7.2), is approximately 2 mg/ml. We do not recommend storing the aqueous solution for more than one day.

Saxagliptin hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Saxagliptin hydrate Suppliers

China 168 India 6 United Kingdom 2 United States 11 Global 187

Hefei QiChang Biological Technology Co., Ltd.

Tel: 18019964904; 17756579152
Fax: QQ:252833506
Email: liuchun.0228@163.com
Country: China
ProdList: 48
Advantage: 58

NanJing Jiexin chemicals Co.,Ltd

Tel: 15005178685; 15005178685
Email: 1347015058@qq.com
Country: China
ProdList: 91
Advantage: 58

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 400-880-2824 18107960669
Fax: 18140514863
Email: 79046690@qq.com
Country: China
ProdList: 1267
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9809
Advantage: 59

Jiangsu Vcare PharmaTech Co., Ltd.

Tel: 13327700685
Fax: +86-25-58744115
Email: sales@vcarepharmatech.com
Country: China
ProdList: 310
Advantage: 61

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8842
Advantage: 52

Synthetics China Co.,Ltd

Tel: 0512-65218020; 18261037325
Email: ivy.shen@pharmsyn.com
Country: China
ProdList: 101
Advantage: 60

Beijing Yisiyan Technology Research Center

Tel: 010-56645598 13366904824
Fax: 01062230033
Email: bjkaida@163.com
Country: China
ProdList: 1637
Advantage: 59

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View Lastest Price from Saxagliptin hydrate manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Saxagliptin hydrate 945667-22-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

Zhuozhou Wenxi import and Export Co., Ltd

Product: Saxagliptin hydrate 945667-22-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Saxagliptin hydrate 945667-22-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

945667-22-1, Saxagliptin hydrateRelated Search:

Saxagliptin 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3R,5R)- (1R, 3R, 5R, 2R)-Saxagliptin (1S, 3R, 5R, 2'S)-Saxagliptin (1R, 3S, 5S, 2'S)-Saxagliptin 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1S,3S,5S)- 1H-Pyrrole-1-carboxylic acid, 2-(aMinocarbonyl)-2,3-dihydro-, 1,1-diMethylethyl ester, (2S)- (S) - N- Boc- adamantylglycine (S)-1-Boc-2,3-dihydro-2-pyrrolecarboxylic acid ethyl ester 2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) 3-ethyl ester, (1S,3S,5S)- N-Boc-L-trans-4,5-Methanoproline (2R)-1,2-Pyrrolidinedicarboxylic acid 1-tert-butyl 2-ethyl ester (1S,3S,5S)-2-(TERT-BUTOXYCARBONYL)-2-AZABICYCLO[3.1.0]HEXANE-3-CARBOXYLIC ACID DSLXQSYLYSTVKT-ONZQNKQFSA-N 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1S,3R,5S)- AcetaMide, N-[(1S)-2-[(1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hex-2-yl]-1-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-2-oxoethyl]-2,2,2-trifluoro- [15N,2H2]-Saxagliptin Hydrochloride Saxagliptin hydrochloride

2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, hydrate (1:1), (1S,3S,5S)-

Saxagliptin hydrate

Saxagliptin hydrate Unii-9gb927lajw

(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrate

Saxagliptin hydrate (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrate

CS-1180

BMS 477118 hydrate

BMS477118 hydrate

BMS-477118 hydrate

BMS-477118 HYDRATE;BMS 477118 HYDRATE;BMS477118 HYDRATE

Saxagliptin hydrate (BMS-477118 hydrate)

Onglyza hydrate

(1S,3S,5S)-2-((2S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrate

(1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile

Saxagliptin MonohydrateQ: What is Saxagliptin Monohydrate Q: What is the CAS Number of Saxagliptin Monohydrate Q: What is the storage condition of Saxagliptin Monohydrate Q: What are the applications of Saxagliptin Monohydrate

(1S,3S,5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile monohydrate

4-trifluorosulfoyl-3'-trifluoroacetamino-4-demethyldaunorubicin

Shagliptin monohydrate

945667-22-1

C18H25N3O2H2O

Saxagliptin hydrate

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