Halofuginone Hydrochloride

Product Name: Halofuginone Hydrochloride
CAS No.: 1217623-74-9
Chemical Name: Halofuginone Hydrochloride
Synonyms: CID 46781676;Halofuginone HCl;4(3H)-Quinazolinone, 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-, hydrochloride (1:1), rel-
CBNumber: CB92545171
Molecular Formula: C16H18BrCl2N3O3
Formula Weight: 451.14242
MOL File: 1217623-74-9.mol

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Halofuginone Hydrochloride Property

Melting point:: 247-249°C (dec.)
storage temp.: -20°C Freezer, Under Inert Atmosphere
solubility: DMSO: soluble; Water: soluble
form: A crystalline solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13370
Product name: Halofuginone (hydrochloride)
Purity: ≥95%
Packaging: 500μg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 13370
Product name: Halofuginone (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $218
Updated: 2024/03/01

Cayman Chemical

Product number: 13370
Product name: Halofuginone (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $481
Updated: 2024/03/01

TRC

Product number: H102500
Product name: HalofuginoneHydrochloride
Packaging: 5mg
Price: $305
Updated: 2021/12/16

TRC

Product number: H102500
Product name: HalofuginoneHydrochloride
Packaging: 10mg
Price: $490
Updated: 2021/12/16

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Halofuginone Hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Halofuginone is a halogenated derivative of Febrifugine (F228500). Halofuginone is used as an antiprotozoal.

Uses

Halogenated derivative of Febrifugine. Used as an antiprotozoal.

in vivo

Halofuginone hydrobromid (0.2, 0.5, 1 or 2.5 mg/kg; injected intraperitoneally every other day for 1 month) attenuates progression of OA in anterior cruciate ligament transection (ACLT) mice. Lower concentration (0.2 or 0.5 mg/kg) has minimal effects on subchondral bone and higher concentration (2.5 mg/kg) induces proteoglycan loss in articular cartilage^[3].
Halofuginone hydrobromid (0.25 mg/kg; intraperitoneally injected; every day; 16 days) decreases NRF2 protein levels in tumors. While the tumor volumes do not change substantially between treatments with the vehicle, Halofuginone hydrobromid (0.25 mg/kg, intraperitoneally injected, every day) or cisplatin alone. Combined treatment with Halofuginone and Cisplatin significantly suppresses the tumor volume compared to treatment with Halofuginone or cisplatin alone^[1].
Intraperitoneal hydrobromid administration of Halofuginone (0.3mg/kg, for 2 weeks) partially reverses the established pulmonary hypertension in mice^[5].

Animal Model:	3-month-old male C57BL/6J (WT) mice^[3]
Dosage:	0.2, 0.5, 1 or 2.5 mg/kg
Administration:	Injected intraperitoneally every other day for 1 month
Result:	Attenuated progression of OA in ACLT mice.

Animal Model:	Male nude mice (BALB/C nu/nu mice) (6-8-week)^[1]
Dosage:	0.25 mg/kg
Administration:	Intraperitoneally injected; every day; 16 days
Result:	The combined treatment with Cisplatin significantly suppressed the tumor volume. NRF2 protein levels in tumors were indeed decreased.

Halofuginone Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Halofuginone Hydrochloride Suppliers

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Halofuginone HCl

4(3H)-Quinazolinone, 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-, hydrochloride (1:1), rel-

CID 46781676

1217623-74-9

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