ChemicalBook > CAS DataBase List > GRANISETRON IMPURITY B

GRANISETRON IMPURITY B

Product Name
GRANISETRON IMPURITY B
CAS No.
76272-56-5
Chemical Name
GRANISETRON IMPURITY B
Synonyms
EMANA;Granisetron EP impurity E;Granisetron EP Impurity E HCl;Endo-3-Amine-9-Methyl-Azabicyc;Granisetron IMpurity E (free base);Granisetron USP Related Compound E;Granisetron Hydrochloride Impurity E;Granisetron EP Impurity E Acetic acid;9-Methyl-9-azabicyclo[3.3.1]nonylamine;Granisetron Hydrochloride EP Impurity E
CBNumber
CB9254802
Molecular Formula
C9H18N2
Formula Weight
154.26
MOL File
76272-56-5.mol
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GRANISETRON IMPURITY B Property

Boiling point:
115-119°C (18 mmHg)
Density 
0.968±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Oil
pka
11.09±0.40(Predicted)
color 
Colourless to Dark Yellow
Stability:
Hygroscopic
InChI
InChI=1/C9H18N2/c1-11-8-3-2-4-9(11)6-7(10)5-8/h7-9H,2-6,10H2,1H3/t7-,8+,9-
InChIKey
HTZWHTQVHWHSHN-AYMMMOKONA-N
SMILES
CN1[C@H]2CCC[C@@H]1C[C@H](N)C2 |&1:2,6,8,r|
CAS DataBase Reference
76272-56-5(CAS DataBase Reference)
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Safety

HS Code 
2921490090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000395
Product name
Granisetron impurity E
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
15 mg
Price
$201
Updated
2025/07/31
Sigma-Aldrich
Product number
Y0000395
Product name
Granisetron impurity E
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
Y0000395
Price
$197
Updated
2024/03/01
TRC
Product number
M288600
Product name
endo-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine
Packaging
50mg
Price
$55
Updated
2021/12/16
Matrix Scientific
Product number
074391
Product name
Endo-3-Amine-9-methyl-9-azabicyclo[3,3,1]nonane
Purity
95+%
Packaging
1g
Price
$22
Updated
2021/12/16
AK Scientific
Product number
K306
Product name
Endo-3-amino-9-methyl-9-azabicyclo[3.3.1]nonane
Packaging
1g
Price
$22
Updated
2021/12/16
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GRANISETRON IMPURITY B Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Oil

Uses

Granisetron impurity E. An intermediate of Granisetron.

Synthesis

6164-67-6

76272-41-8

9-Methyl-9-azabicyclo[3,3,1]nonan-3-one oxime (10 g, 0.06 mol) was used as a raw material and dissolved in methanol (70 mL) and 0.88 ammonia. The hydrogenation reaction was carried out at 50 °C and 50 psi (344.8 kPa) hydrogen pressure for 16 h using 5% rhodium/carbon catalyst (1 g dry weight). Upon completion of the reaction, the mixture was cooled to room temperature and the catalyst was removed by filtration. The catalyst bed was washed with methanol and the methanol solution was subsequently evaporated under reduced pressure to afford endo-3-amino-9-methyl-9-azabicyclo[3,3,1]nonane as an oil (8.6 g, 93% yield), which solidified to a waxy solid (8.6 g, 93%) upon standing. EI analysis by GC/MS (JEOL DX303) showed the molecular ion peak m/z 154 (M+).

References

[1] Patent: US5856489, 1999, A

GRANISETRON IMPURITY B Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GRANISETRON IMPURITY B manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
GRANISETRON IMPURITY B 76272-56-5
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
98%min GC
Supply Ability
10KGS
Release date
2021-07-21
Career Henan Chemical Co
Product
Endo-3-amine-9-methyl-9-azabicyclo[3,3,1]nonane 76272-56-5
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100KG
Release date
2018-12-17

76272-56-5, GRANISETRON IMPURITY BRelated Search:

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  • Granisetron IMpurity E (free base)
  • (1R)-9-Methyl-9-azabicyclo[3.3.1]nonan-3-aMine
  • endo-3-AMino-9-Methyl-9-azabicyclo[3,3,1]nonane(endo/exo ca 5/1)
  • Endo-3-aMin-9-Methyl-9-azabicyclo[3,3,1] nonane
  • (3-endo)-9-Methyl-9-Azabicyclo[3.3.1]nonan-3-aMine
  • Endo-3-amine-9-methyl-9-azabicyclo[3,3,1]nonane Endo-9-methyl-9-azabicyclo[3,3,1]nonan-3-amine
  • (1R,3r,5S)-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine
  • <i>endo</i>-3-Amino-9-methyl-9-azabicyclo[3,3,1]nonane(endo/exo ca 5/1)
  • ndo-3-amine-9-methyl-9-azabicyclo[3,3,1]nonane
  • Granisetron EP impurity E
  • endo‐1‐Amino‐9‐methyl‐9‐azabicyclo[3.3.1]nonane
  • 9-methyl-9-azabicyclo[3.3.1]nonan-5-amine
  • ENDO-3-AMINE-9-METHYL-9-AZABICYCLO[3,3,1]NONAN
  • ENDO-3-AMINE-9-METHYL-9-AZABICYCLO[3,3,1]NONANE
  • ENDO-3-AMINE-9-METHYL-AZABICYCLO[3.3.1] NONANE
  • ENDO-3-AMINO-9-METHYL-9-AZABICYCLO[3.3.1]NONANE
  • ENDO-9-METHYL-9-AZA-BICYCLO[3.3.1]NON-3-YLAMINE
  • ENDO-9-METHYL-9-AZABICYCLO3,3,1-NONAN-3-AMINE
  • ENDO-9-METHYL-9-AZABICYCLO[3,3,1] NONANE-3-AMINE
  • EMANA
  • Endo-9-Methyl-9-Azabicyclo-3,3,1-Nonan-3-Amine(ForGranisetronHcl)
  • b-3-Amino-9-methyl-9-azabicyclo(3.3.1)-nonane, Granisetron Impurity E (free base)
  • Endo-3-Amine-9-Methyl-Azabicyc
  • Endo-9-methyl-9-azabicyclo[3,3,1] nonan-3-amine 76272-56-5
  • ENDO-9-METHYL-9-AZABICYCLO[3,3,1]-NONAN-3- AMINE / EMANA
  • 9-Methyl-9-azabicyclo[3.3.1]nonylamine
  • 1-AMINO-9-METHYL-9-AZABICYCLO[3,3,1]-NONANE
  • 9-METHYL-9-AZA-BICYCLO[3,3,1]NON-3-YL-AMINE
  • endo-9-Methyl-9-azabicyclo[3.3.1]-3-nonylamine
  • EMANA(Endo-9-methyl-9-azabicyclo[3,3,1]-nonan-3-amine)
  • do-3-amine-9-methyl-9-azabicyclo[3,3,1]nonane
  • endo-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine (Granisetron Impurity E)
  • 9-Azabicyclo[3.3.1]nonan-3-amine, 9-methyl-, (3-endo)-
  • Endo-9-Methy -9-Azabicyclo[3,31]Nonan-3-Amine
  • -3-Amino-9-methyl-9-azabicyclo(3.3.1)-nonane, Granisetron Impurity E (free base)
  • Granisetron EP Impurity E Acetic acid
  • Granisetron EP Impurity E HCl
  • ENDO-9-METHYL-9-AZABICYCLO [3,3,1]-NONAN-3-AMIN
  • Granisetron USP Related Compound E
  • Granisetron Hydrochloride Impurity E
  • Endo-9-methyl-9-azabicycolo [3.3.1] nonan-3-amine
  • Granisetron Hydrochloride EP Impurity E
  • Introverted 3-amino-9-methyl-9-azabicyclic [3,3,1] nonane
  • 9-Methyl-9-Azabicyclo[3,3,1]Nonane-3Amine
  • rel-(1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine
  • 76272-56-5
  • Amines
  • Chiral Reagents
  • Impurities
  • Intermediates & Fine Chemicals
  • (intermediate of granisetron)
  • Amines and Anilines
  • Heterocycles
  • Pharmaceuticals