Azelastine hydrochloride

Product Name: Azelastine hydrochloride
CAS No.: 79307-93-0
Chemical Name: Azelastine hydrochloride
Synonyms: AZELASTINE HCL;Astelin;Optivar;1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride;4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone, hydrochloride (1:1);Azen;a5610;e-0659;Azepit;w-2979m
CBNumber: CB9256008
Molecular Formula: C22H25Cl2N3O
Formula Weight: 418.36
MOL File: 79307-93-0.mol

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Azelastine hydrochloride Property

Melting point:: 225--2290C
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: >10mg/mL
form: powder
color: white to off-white
Merck: 14,906
Stability:: Incompatible with strong oxidizing agents.
InChI: InChI=1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H
InChIKey: YEJAJYAHJQIWNU-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=CC=C2)C(CC2=CC=C(Cl)C=C2)=NN1C1CCCN(C)CC1.[H]Cl
CAS DataBase Reference: 79307-93-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
RTECS: TH9203900
HS Code: 2933992600
Toxicity: LD50 in male, female mice, male, female rats (mg/kg): 36.5, 35.5, 26.9, 30.3 i.v.; 56.4, 42.8, 43.2, 46.6 i.p.; 63.0, 54.2, 66.5, 59.6 s.c.; 124, 139, 310, 417 orally (Zechel)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000326
Product name: Azelastine hydrochloride
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 25 mg
Price: $225
Updated: 2025/07/31

Sigma-Aldrich

Product number: A7611
Product name: Azelastine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $84.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: A7611
Product name: Azelastine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $318.25
Updated: 2025/07/31

TCI Chemical

Product number: A2340
Product name: Azelastine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $187
Updated: 2025/07/31

TCI Chemical

Product number: A2340
Product name: Azelastine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 100mg
Price: $37
Updated: 2025/07/31

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Azelastine hydrochloride Chemical Properties,Usage,Production

Description

Azelastine hydrochloride is an orally effective antihistamine useful in the treatment of asthma and nasal allergy. It appears to inhibit release of histamine, in addition to antagonizing its action.

Chemical Properties

White or almost white, crystalline powder.

Originator

Asta-Werke(Degussa) (W. Germany)

Uses

Orally active H1-hystamine receptor antagonist. Antihistaminic

Definition

ChEBI: The hydrochloride salt of azelastine.

Application

Azelastine Hydrochloride is the hydrochloride salt form of azelastine, a phthalazinone derivative with antihistaminergic activity. Azelastine hydrochloride exhibits histamine H1-receptor antagonist activity in isolated tissues, animal models, and humans. Azelastine hydrochloride nasal solution is administered as a racemic mixture, and no difference in pharmacologic activity was noted between the enantiomers in vitro studies. The major metabolite, desmethylazelastine, also possesses H1-receptor antagonist activity. It competes with histamine for the H1 receptor, thereby diminishing the actions of histamine on effector cells and decreasing the histamine-mediated symptoms of allergic reaction, such as bronchoconstriction, vasodilation, increased capillary permeability and spasmodic contractions of gastrointestinal smooth muscle.

brand name

Astelin (Medpointe); Optivar (Medpointe);AZEPTIN.

General Description

(±)-4-[(4-chlorophenyl)methyl]-2-(hexahydro-l-methyl-1H-azepin-4-yl)-l-(2H)-phthalazinone monohydrochloride (Optivar), is a whitecrystalline powder that is sparingly soluble in water,methanol, and propylene glycol and slightly soluble inethanol, octanol, and glycerine. The commercial preparationis available as a 0.05% sterile ophthalmic solution fortopical administration to the eyes. Each milliliter of azelastinesolution contains 0.5-mg azelastine hydrochlorideequivalent to 0.457 mg of azelastine base, the preservativebenzalkonium chloride (0.125 mg), and inactive ingredientsincluding disodium edetate dihydrate, hydroxypropylmethylcellulose,sorbitol solution, sodium hydroxide, andwater for injection. The solution has a pH of approximately5.0 to 6.5 and an osmolality of approximately 271to 312 mOsm/L.
The recommended dose of azelastine solution is 1 dropinstilled into each affected eye twice a day. This drugproduct is for ocular administration only and not for injectionor oral use. Absorption of azelastine following ocularadministration is relatively low (less than 1 ng/rnL).Absorbed drug undergoes extensive oxidative N-demethylationby CYP, and the parent drug and metabolite are eliminatedprimarily in the feces. The most frequently reportedadverse reactions are transient eye burning or stinging,headaches, and bitter taste. Azelastine solution should beused with caution during pregnancy or while nursing, becauseits safety has not been studied under these circumstances.

Biochem/physiol Actions

H1 histamine receptor antagonist; NF-kB activator.

Safety Profile

Poison by ingestion andintravenous routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of NOx and HCl.

Azelastine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Azelastine hydrochloride Suppliers

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View Lastest Price from Azelastine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Azelastine hydrochloride 79307-93-0
Price: US $0.00/g
Min. Order: 100g
Purity: 99%min
Supply Ability: 300kg/month
Release date: 2025-09-22

Shaanxi Dideu Medichem Co. Ltd

Product: Azelastine Hydrochloride 79307-93-0
Price: US $1.00-4.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2025-05-14

Shaanxi Dideu Medichem Co. Ltd

Product: Azelastine hydrochloride 79307-93-0
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-08

79307-93-0, Azelastine hydrochlorideRelated Search:

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a5610

azeptin

e-0659

w-2979m

AZELASTINE HCL

AZELASTINE HYDROCHLORIDE

4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one hydrochloride

4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Hydrochloride

Allergodil

Astelin

Optilast

Rhinolast

Aselastine

1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride

Acelastine hydrochloride

4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone, hydrochloride (1:1)

Optivar

Adomessen

Asutoputin

Azen

Azepit

Azelastine HCI

Azelastine-d4 hydrochloride

AZWLASTINE HYDROCHLORIDE API

4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)-1-phthalazinone Hydrochloride

Azelastine hydrochloride (Allergodil)

Azelastine-d4 HCl

Azelastine HCl (Allergodil)

Azelastine hydrochloride CRS

Azelastine Hydrochloride &gt

4-hydrazineyl-1-methylazepane hydrogen chloride

4-(4-Chlorobenzyl)-2-[(4RS)-1-methylhexahydro-1H-azepin-4-yl]phthalazin-1(2H)-one hydrochloride

Azelastine hydrochloride USP/EP/BP

Azelastine hydrochloride (API)

Azelastine HydrochlorideQ: What is Azelastine Hydrochloride Q: What is the CAS Number of Azelastine Hydrochloride Q: What is the storage condition of Azelastine Hydrochloride

Azelastine Hydrochloride (1046158)

4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-1,2-dihydrophthalazin-1-one hydrochloride

Azelastine hydrochloride, 10 mM in DMSO

Azelastine HCl - Bio-X ?

Azelastine Hydrochloride 1.0 mg/ml in Methanol (as free base)

79307-93-0

C22H24ClN3OHCl

C22H27Cl2N3O

C22H25Cl2N3O

C22H24ClN3OClH

Antihistaminic

Astelin

Intermediates & Fine Chemicals

Pharmaceuticals

Histamine receptor