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SMER 28

Product Name
SMER 28
CAS No.
307538-42-7
Chemical Name
SMER 28
Synonyms
CS-2308;SMER 28;SMER-28;SMER 28;N-Allyl-6-bromoquinazolin-4-amine;SMER28 - CAS 307538-42-7 - Calbiochem;6-BroMo-N-2-propenyl-4-QuinazolinaMine;6-Bromo-N-prop-2-enylquinazolin-4-amine;6-BroMo-N-2-propen-1-yl-4-quinazolinaMine;4-Quinazolinamine, 6-bromo-N-2-propen-1-yl-
CBNumber
CB92561083
Molecular Formula
C11H10BrN3
Formula Weight
264.12
MOL File
307538-42-7.mol
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SMER 28 Property

Melting point:
171-173 °C
Boiling point:
391.6±32.0 °C(Predicted)
Density 
1.520±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
solid
pka
6.12±0.50(Predicted)
color 
Beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
37/38-41
Safety Statements 
26-36/37
WGK Germany 
3
HS Code 
2933.59.8000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S8197
Product name
SMER 28
Purity
>99% (HPLC), solid
Packaging
5mg
Price
$104.4
Updated
2024/03/01
Sigma-Aldrich
Product number
573121
Product name
SMER28
Packaging
10mg
Price
$179
Updated
2024/03/01
TCI Chemical
Product number
M3106
Product name
SMER 28
Packaging
25MG
Price
$198
Updated
2024/03/01
TCI Chemical
Product number
M3106
Product name
SMER 28
Packaging
100MG
Price
$541
Updated
2024/03/01
Cayman Chemical
Product number
17768
Product name
SMER 28
Purity
≥98%
Packaging
5mg
Price
$49
Updated
2024/03/01
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SMER 28 Chemical Properties,Usage,Production

Description

SMER28 (CAS 307538-42-7) Induces autophagy via an mTOR-independent pathway. Enhances clearance of ?-amyloid protein in cell lines and primary neuronal culture models.1-3? May be a useful lead compound for the development of new therapeutics for neurodegenerative diseases.4?Induces the release of articular cartilage vesicles from healthy articular chondrocytes in a dose- and time-dependent manner.5? Promotes reprogramming of fibroblasts to neural stem-like cells.6?Cell permeable.

Uses

SMER 28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. SMER 28 increases autophagosome synthesis and enhances clearance of model autophagy substrates such as A53T α-synuclein associated with Huntington''s disease.

Uses

SMER28 may be used in mTOR-mediated signaling studies.

Definition

ChEBI: SMER 28 is a member of the class of quinazolines that is quinazoline which is substituted by a prop-2-en-1-ylnitrilo group and a bromo group at positions 4 and 6, respectively. It is a modulator of mammalian autophagy. It has a role as an autophagy inducer. It is a member of quinazolines, a secondary amino compound and an organobromine compound.

Biochem/physiol Actions

SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.

in vitro

smer 28 independently induced autophagy of rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as a53t a-synuclein and mutant huntingtin, which were associated with huntington’s and parkinson’s disease. smer 28, which seemed to act either independently or downstream of the rapamycin target, was found to attenuate the mutant huntingtin-fragment toxicity in huntington’s disease cells [1].

in vivo

previous study confirmed that the reduction of egfp-hdq74 aggregation occured through autophagy using autophagy-competent mouse embryonic fibroblasts (mefs) (atg5+/+). egfp-hdq74 aggregation was increased significantly in untreated atg5-/- (autophagy-deficient) cells when compared with untreated atg5+/+ cells. smer 28 reduced egfp-hdq74 aggregation in atg5+/+ cells significantly, but not in atg5-/- cells). therefore, smer 28 could only reduce mutant huntingtin aggregation in autophagy-competent cells [1].

storage

Store at +4°C

References

1) Tian et al. (2011), A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway; FASEB J., 25 1934 2) Tian et al. (2014), The convergence of endosomal and autophagosomal pathways; implications for APP-CTF degradation; Autophagy, 10 694 3) Shen et al. (2011), Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies; Cell Biochem. Biophys., 60 173 4) Renna et al. (2010), Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases; J. Biol. Chem., 285 11061 5) Rosenthal et al. (2015), Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes; J. Biol. Chem., 290 13028 6) Zhang et al. (2016), Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation; Cell Stem Cell., 18 653

SMER 28 Preparation Products And Raw materials

Raw materials

Preparation Products

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SMER 28 Suppliers

TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from SMER 28 manufacturers

Career Henan Chemical Co
Product
6-bromo-N-prop-2-enylquinazolin-4-amine 307538-42-7
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-20

307538-42-7, SMER 28Related Search:


  • SMER 28
  • 6-Bromo-N-prop-2-enylquinazolin-4-amine
  • SMER28 - CAS 307538-42-7 - Calbiochem
  • CS-2308
  • SMER-28;SMER 28
  • 6-BroMo-N-2-propen-1-yl-4-quinazolinaMine
  • 6-BroMo-N-2-propenyl-4-QuinazolinaMine
  • 4-Quinazolinamine, 6-bromo-N-2-propen-1-yl-
  • N-Allyl-6-bromoquinazolin-4-amine
  • 307538-42-7
  • API