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SMER 28

Product Name
SMER 28
CAS No.
307538-42-7
Chemical Name
SMER 28
Synonyms
CS-2308;SMER 28;SMER-28;SMER 28;N-Allyl-6-bromoquinazolin-4-amine;SMER28 - CAS 307538-42-7 - Calbiochem;6-BroMo-N-2-propenyl-4-QuinazolinaMine;6-Bromo-N-prop-2-enylquinazolin-4-amine;6-BroMo-N-2-propen-1-yl-4-quinazolinaMine;4-Quinazolinamine, 6-bromo-N-2-propen-1-yl-
CBNumber
CB92561083
Molecular Formula
C11H10BrN3
Formula Weight
264.12
MOL File
307538-42-7.mol
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SMER 28 Property

Melting point:
171-173 °C
Boiling point:
391.6±32.0 °C(Predicted)
Density 
1.520±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
solid
pka
6.12±0.50(Predicted)
color 
Beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
37/38-41
Safety Statements 
26-36/37
WGK Germany 
3
HS Code 
2933.59.8000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S8197
Product name
SMER 28
Purity
>99% (HPLC), solid
Packaging
5mg
Price
$104.4
Updated
2024/03/01
Sigma-Aldrich
Product number
573121
Product name
SMER28
Packaging
10mg
Price
$179
Updated
2024/03/01
TCI Chemical
Product number
M3106
Product name
SMER 28
Packaging
25MG
Price
$198
Updated
2024/03/01
TCI Chemical
Product number
M3106
Product name
SMER 28
Packaging
100MG
Price
$541
Updated
2024/03/01
Cayman Chemical
Product number
17768
Product name
SMER 28
Purity
≥98%
Packaging
5mg
Price
$49
Updated
2024/03/01
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SMER 28 Chemical Properties,Usage,Production

Description

SMER28 (CAS 307538-42-7) Induces autophagy via an mTOR-independent pathway. Enhances clearance of ?-amyloid protein in cell lines and primary neuronal culture models.1-3? May be a useful lead compound for the development of new therapeutics for neurodegenerative diseases.4?Induces the release of articular cartilage vesicles from healthy articular chondrocytes in a dose- and time-dependent manner.5? Promotes reprogramming of fibroblasts to neural stem-like cells.6?Cell permeable.

Uses

SMER 28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. SMER 28 increases autophagosome synthesis and enhances clearance of model autophagy substrates such as A53T α-synuclein associated with Huntington''s disease.

Uses

SMER28 may be used in mTOR-mediated signaling studies.

Definition

ChEBI: SMER 28 is a member of the class of quinazolines that is quinazoline which is substituted by a prop-2-en-1-ylnitrilo group and a bromo group at positions 4 and 6, respectively. It is a modulator of mammalian autophagy. It has a role as an autophagy inducer. It is a member of quinazolines, a secondary amino compound and an organobromine compound.

Biochem/physiol Actions

SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.

in vitro

smer 28 independently induced autophagy of rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as a53t a-synuclein and mutant huntingtin, which were associated with huntington’s and parkinson’s disease. smer 28, which seemed to act either independently or downstream of the rapamycin target, was found to attenuate the mutant huntingtin-fragment toxicity in huntington’s disease cells [1].

in vivo

previous study confirmed that the reduction of egfp-hdq74 aggregation occured through autophagy using autophagy-competent mouse embryonic fibroblasts (mefs) (atg5+/+). egfp-hdq74 aggregation was increased significantly in untreated atg5-/- (autophagy-deficient) cells when compared with untreated atg5+/+ cells. smer 28 reduced egfp-hdq74 aggregation in atg5+/+ cells significantly, but not in atg5-/- cells). therefore, smer 28 could only reduce mutant huntingtin aggregation in autophagy-competent cells [1].

storage

Store at +4°C

References

1) Tian et al. (2011), A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway; FASEB J., 25 1934 2) Tian et al. (2014), The convergence of endosomal and autophagosomal pathways; implications for APP-CTF degradation; Autophagy, 10 694 3) Shen et al. (2011), Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies; Cell Biochem. Biophys., 60 173 4) Renna et al. (2010), Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases; J. Biol. Chem., 285 11061 5) Rosenthal et al. (2015), Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes; J. Biol. Chem., 290 13028 6) Zhang et al. (2016), Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation; Cell Stem Cell., 18 653

SMER 28 Preparation Products And Raw materials

Raw materials

Preparation Products

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SMER 28 Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
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View Lastest Price from SMER 28 manufacturers

Career Henan Chemical Co
Product
6-bromo-N-prop-2-enylquinazolin-4-amine 307538-42-7
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-20

307538-42-7, SMER 28Related Search:


  • SMER 28
  • 6-Bromo-N-prop-2-enylquinazolin-4-amine
  • SMER28 - CAS 307538-42-7 - Calbiochem
  • CS-2308
  • SMER-28;SMER 28
  • 6-BroMo-N-2-propen-1-yl-4-quinazolinaMine
  • 6-BroMo-N-2-propenyl-4-QuinazolinaMine
  • 4-Quinazolinamine, 6-bromo-N-2-propen-1-yl-
  • N-Allyl-6-bromoquinazolin-4-amine
  • 307538-42-7
  • API