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Pioglitazone

Product Name
Pioglitazone
CAS No.
111025-46-8
Chemical Name
Pioglitazone
Synonyms
U 72107;PINEPOLLEN;Pioglitazone;Pioglitozaone;Pioglitazone (Actos);Pioglitazone free base;Pioglitazone USP/EP/BP;Pioglitazone (AD-4833);Phenyl Acetate Impurity 45;Pioglitazone and its intermeidates
CBNumber
CB9257580
Molecular Formula
C19H20N2O3S
Formula Weight
356.44
MOL File
111025-46-8.mol
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Pioglitazone Property

Melting point:
183-184 C
Boiling point:
575.4±45.0 °C(Predicted)
Density 
1.260±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly, Heated)
form 
White to off-white solid.
pka
6.35±0.50(Predicted)
color 
White to Off-White
IARC
2A (Vol. 108) 2016
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Safety

Hazard Codes 
F,C
Risk Statements 
11-34
Safety Statements 
16-26-36/37/39-45
Hazardous Substances Data
111025-46-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

H351Suspected of causing cancer

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
71745
Product name
Pioglitazone
Purity
≥98%
Packaging
1mg
Price
$22
Updated
2024/03/01
Cayman Chemical
Product number
71745
Product name
Pioglitazone
Purity
≥98%
Packaging
5mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
71745
Product name
Pioglitazone
Purity
≥98%
Packaging
25mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
71745
Product name
Pioglitazone
Purity
≥98%
Packaging
50mg
Price
$145
Updated
2024/03/01
TRC
Product number
P469995
Product name
Pioglitazone
Packaging
1g
Price
$165
Updated
2021/12/16
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Pioglitazone Chemical Properties,Usage,Production

Description

Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ). It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 μM and 5.4-fold activation at a concentration of 10 μM. Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM. In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats. It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model. Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW9662 .

Originator

Actos ,Eli Lilly ,USA

Uses

Pioglitazone shows antidiabetic activity in patients with type 2 diabetes mellitus.

Uses

antihyperlipidemic, HMGCoA reductase inhibitor

Definition

ChEBI: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic acti ity.

Indications

Pioglitazone is approved for use as monotherapy and in conjunction with metformin, sulfonylureas, and insulin. It is taken once a day with or without food. Though pioglitazone may also cause a small increase in low-density lipoprotein concentrations, there is usually a modest decrease in triglyceride levels, but it unclear whether this has any clinical significance or persists in the long term.

Manufacturing Process

To a solution of 2-(5-ethyl-2-pyridyl)ethanol (53.0 g) and 4-fluoronitrobenzene (47.0 g) in DMF (500 ml) was added portionwise under ice-cooling 60% sodium hydride in oil (16.0 g). The mixture was stirred under ice-cooling for one hour, then at room temperature for 30 min, poured into water and extracted with ether. The ether layer was washed with water and dried (MgSO4). The solvent was evaporated off to give 4-[2-(5-ethyl-2pyridyl)ethoxy]nitrobenzene as crystals (62.0 g, 62.9%). Recrystallization from ether-hexane gave colorless prisms, melting point 53°-54°C.
A solution of 4-[2-(5-ethyl-2-pyridyl)ethoxy]nitrobenzene (60.0 g) in methanol (500 ml) was hydrogenated at room temperature under one atmospheric pressure in the presence of 10% Pd-C (50% wet, 6.0 g). The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The residual oil was dissolved in acetone (500 ml)methanol (200 ml). To the solution was added a 47% HBr aqueous solution (152 g). The mixture was cooled, to which was added dropwise a solution of NaNO2 (17.3 g) in water (30 ml) at a temperature not higher than 5°C. The whole mixture was stirred at 5°C for 20 min, then methyl acrylate (112 g) was added thereto and the temperature was raised to 38°C. Cuprous oxide (2.0 g) was added to the mixture in small portions with vigorous stirring. The reaction mixture was stirred until nitrogen gas evolution ceased, and was concentrated under reduced pressure. The concentrate was made alkaline with concentrated aqueous ammonia, and extracted with ethyl acetate. The ethyl acetate layer was washed with water and dried (MgSO4) The solvent was evaporated off to leave methyl 2-bromo-3-{4-[2-(5-ethyl-2pyridyl)ethoxy]phenyl}propionate as a crude oil (74.09 g, 85.7%).
A mixture of the crude oil of methyl 2-bromo-3-{4-[2-(5-ethyl-2pyridyl)ethoxy]phenyl}propionate (73.0 g) thiourea (14.2 g), sodium acetate (15.3 g) and ethanol (500 ml) was stirred for 3 hours under reflux. The reaction mixture was concentrated under reduced pressure, and the concentrate was neutralized with a saturated aqueous solution of sodium hydrogencarbonate, to which were added water (200 ml) and ether (100 ml). The whole mixture was stirred for 10 min to yield 5-{4-[2-(5-ethyl-2pyridyl)ethoxy]benzyl}-2-imino-4-thiazolidinone as crystals (0.3 g, 523.0%). Recrystallization from methanol gave colorless prisms, melting point 187°188°C, dec.
A solution of 5-{4-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl}-2-imino-4thiazolidinone (23.5 g) in 2 N HCl (200 ml) was refluxed for 6 hours. The solvent was evaporated off under reduced pressure, and the residue was neutralized with a saturated aqueous solution of sodium hydrogencarbonate. The crystals (23.5 g, 97.5%) which precipitated were collected by filtrationand recrystallized from DMF-H2O to give 5-{4-[2-(5-ethyl-2pyridyl)ethoxy]benzyl}-2,4-thiazolidinedione as colorless needles (20.5 g, 86.9%), melting point 183°-184°C.
In practice it is usually used as hydrochloride salt.

brand name

Actos (Takeda).

Therapeutic Function

Antidiabetic

General Description

Pioglitazone, (±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione (Actos),is an odorless, white, crystalline powder that must be convertedto a salt such as its hydrochloride before it will haveany water solubility. Although the molecule contains one chiralcenter, the compound is used as the racemic mixture. Thisis primarily a result of the in vivo interconversion of the twoenantiomers. Thus, there are no differences in the pharmacologicalactivity of the two enantiomers.

storage

+4°C

Pioglitazone Preparation Products And Raw materials

Raw materials

Pioglitazone hydrochloride 4-Fluoronitrobenzene 2- (5-ethyl-2-pyridyl) ethanol Methyl acrylate

Preparation Products

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View Lastest Price from Pioglitazone manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd
Product
Pioglitazone 111025-46-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2023-02-07
Zhuozhou Wenxi import and Export Co., Ltd
Product
Pioglitazone 111025-46-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Pioglitazone 111025-46-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

111025-46-8, PioglitazoneRelated Search:

Pioglitazone N-Oxide 5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione Pioglitazone Pioglitazone, hydroxy M-IV,Hydroxy Pioglitazone (M-IV) Pioglitazone 5-Ethyl-2-pyridineethanol Pioglitazone hydrochloride 5-{4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl}-2-imino-4-thiazolidinone Thiazole 2,4-Thiazolidinedione Keto Pioglitazone Discontinued see product # K200600,Keto Pioglitazone,Keto-Pioglitazone (M-III),Pioglitazone, ketone N-[Ethyl-(2-pyridyl-5-ethyl) Pioglitazone(Pioglitazone Impurity),4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzenepropanoic Acid Ethyl Ester(Pioglitazone Impurity) Pioglitazone, hydroxyl M-II,Hydroxy Pioglitazone (M-II) (Mixture of Diastereomers) Hydroxy Pioglitazone-D5 (Major) (M-IV) (Mixture of diastereomers) 5-Desethyl 5-Carboxy Pioglitazone 4-METHOXYTOLUENE-2,3,5,6-D4 PINEPOLLEN 5-Hydroxy Pioglitazone

  • Pioglitazone
  • 5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione
  • PIOGLITAZONE HCL(5-[[4-[2-(5-ETHYLPYRIDIN-2-YL)ETHOXY]PHENYL]METHYL]THIAZOLIDINE-2,4-DIONE, HCL)
  • PINEPOLLEN
  • (5S)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione
  • U 72107
  • 5-[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyl]thiazolidine-2,4-dione
  • Pioglitazone (Actos)
  • 2,4-Thiazolidinedione,5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]Methyl]-
  • Pioglitazone 5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
  • Pioglitazone free base
  • Pioglitazone and its intermeidates
  • 5-[4-[2-(5-ETHYL-2-PYRIDINYL)ETHOXY]PHENYL]METHYL-2,4-THIAZOLIDINEDIONE
  • 5-(4-[2-(5-ETHYL-PYRIDIN-2-YL)-ETHOXY]-BENZYL)-THIAZOLIDINE-2,4-DIONE
  • 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
  • Pioglitazone USP/EP/BP
  • PioglitazoneQ: What is Pioglitazone Q: What is the CAS Number of Pioglitazone Q: What is the storage condition of Pioglitazone Q: What are the applications of Pioglitazone
  • Pioglitozaone
  • Phenyl Acetate Impurity 45
  • Pioglitazone (AD-4833)
  • 111025-46-8
  • C19H20N2O3S
  • LESCOL
  • APIS