DIATRIZOIC ACID

ChemicalBook > CAS DataBase List > DIATRIZOIC ACID

Product Name: DIATRIZOIC ACID
CAS No.: 117-96-4
Chemical Name: DIATRIZOIC ACID
Synonyms: diat;odiston;urotrast;NSC-61815;triombrin;Diatrizoic;NSC 262168;diatrizoate;diatriazoate;Diaztrizoate
CBNumber: CB9258330
Molecular Formula: C11H9I3N2O4
Formula Weight: 613.91
MOL File: 117-96-4.mol

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DIATRIZOIC ACID Property

Melting point:: >300°C
Boiling point:: 614.1±55.0 °C(Predicted)
Density: 2.4079 (estimate)
vapor pressure: 0Pa at 20℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Soluble in Methanol.
pka: 0.92±0.10(Predicted)
form: Solid
color: White to Off-White
Water Solubility: 500g/L(25 ºC)
Merck: 14,2992
Stability:: Light Sensitive
InChI: InChI=1S/C11H9I3N2O4/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18/h1-2H3,(H,15,17)(H,16,18)(H,19,20)
InChIKey: YVPYQUNUQOZFHG-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=C(I)C(NC(C)=O)=C(I)C(NC(C)=O)=C1I
LogP: 3.3 at 20℃
EPA Substance Registry System: Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo- (117-96-4)

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Safety

WGK Germany: 3
RTECS: DG5950000
HS Code: 2924.29.7790
Hazardous Substances Data: 117-96-4(Hazardous Substances Data)
Toxicity: LD50 intravenous in mouse: 8900mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D9268
Product name: Diatrizoic acid
Packaging: 50g
Price: $143
Updated: 2024/03/01

Sigma-Aldrich

Product number: 76513
Product name: Amidotrizoic acid
Purity: analytical standard
Packaging: 100mg
Price: $86.2
Updated: 2022/05/15

TCI Chemical

Product number: D1462
Product name: Diatrizoic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $73
Updated: 2024/03/01

Alfa Aesar

Product number: J63444
Product name: Diatrizoic acid
Packaging: 25g
Price: $64.65
Updated: 2024/03/01

Alfa Aesar

Product number: J63444
Product name: Diatrizoic acid
Packaging: 5g
Price: $19.5
Updated: 2021/12/16

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DIATRIZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Hypaque Sodium,Winthrop,US,1955

Uses

Diatrizoic acid is a gradient reagent used for blood cell separation and diagnostic aid (radiopaque medium). Diatrizoic acid may be used as an alternative to barium sulfate for medical imaging of the gastrointestinal tract, such as upper gastrointestinal series and small bowel series.

Uses

Density gradient reagent for blood cell seperation. Diagnostic aid (radiopaque medium)

Uses

radiopaque agent

Definition

ChEBI: A member of the class of benzoic acids that is benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, mainly as its N-methylglucamine and sodium salts, as an -ray contrast medium in gastrointestinal studies, angiography, and urography.

Manufacturing Process

3,5-Dinitrobenzoic acid (15.9 g) was dissolved in an equivalent amount of sodium hydroxide solution, and the solution was diluted to 310 ml with water. The solution was refluxed with Raney nickel for fifteen minutes, filtered, and the filtrate was hydrogenated at elevated pressure using platinum oxide catalyst. After the amount of hydrogen calculated to reduce both nitro groups had been absorbed, the mixture was filtered, and the filtrate was acidified with an equal volume of concentrated hydrochloric acid. Iodine monochloride (17 ml) in 100 ml of 6N HCl was then added with stirring. The reaction mixture was allowed to stand for two and one-half hours at room temperature, then diluted with an equal amount of water with vigorous stirring, and the solid material was collected by filtration and recrystallized
from dilute methanol, giving 18.5 g of 3,5-diamino-2,4,6-triiodobenzoic acid, MP about 135°C with decomposition. The 18.5 g of 3,5-diamino-2,4,6- triiodobenzoic acid was suspended in 150 ml of acetic anhydride containing 5 drops of 70% perchloric acid, and the mixture was heated on a steam bath for three and one-half hours. The reaction mixture was poured into 300 ml of ice water, and then heated on a steam bath until crystallization took place. The solid material was collected by filtration, dissolvedin dilute sodium hydroxide solution, filtered, and hydrochloric acid was added to the filtrate to reprecipitate the acid product. The latter was again dissolved in sodium hydroxide and reprecipitated with acid, giving 9 g of 3,5-diacetamido-2,4,6- triiodobenzoic acid, MP above 250°C.
The acid may be used as the sodium salt or as the meglumate.

brand name

Md (Mallinckrodt); Urovist Sodium (Berlex).

Therapeutic Function

Diagnostic aid (radiopaque medium)

General Description

Diatrizoate is a water-soluble, ionicmonomer. It is commercially available as the megluminesalt, sodium salt, or as fixed combinations of the two saltforms. These triiodobenzoic acid salts contain 47% organicallybound iodine.
Numerous products with various concentrations of one ortwo of the salt forms are available for various imaging procedures.Indicated uses include angiography, venography,excretory urography, retrograde cystourethrography, retrogradeor ascending pyelography, operative, T-tube, or percutaneoustranshepatic cholangiography, splenoportography,arthrography; discography, radiographic examinationof the GI tract when barium sulfate is contraindicated (i.e.,suspected perforation of the GI tract), adjunct contrast enhancementin CT of the torso (dual contrast study), and hysterosalpingography.

DIATRIZOIC ACID Preparation Products And Raw materials

Raw materials

3,5-Diaminobenzoic acid ACETYL IODIDE

Preparation Products

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View Lastest Price from DIATRIZOIC ACID manufacturers

Asia Chem I and E (Jiangsu) Co Ltd

Product: Diatrizoic acid 117-96-4
Price: US $348.84/Kg/Drum
Min. Order: 25Kg/Drum
Purity: 99.00%HPLC
Supply Ability: 1.5tons/month
Release date: 2021-09-24

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Diatrizoic acid 117-96-4
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%-102%;USP
Supply Ability: 500KGS
Release date: 2021-06-29

Shaanxi Dideu Medichem Co. Ltd

Product: Diatrizoic acid 117-96-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000KG
Release date: 2024-07-30

117-96-4, DIATRIZOIC ACIDRelated Search:

Ioversol Diatrizoate sodium MEGLUMINE DIATRIZOATE Diatrizoic Acid Dihydrate Metrizoic acid DIATRIZOIC ACID iosulamide sodium metrizoate Amidotrizoic Acid EP Impurity D Ethyl cartrizoate Sodium diprotrizoate Ioxotrizoic acid iosulamide meglumine SODIUM DIATRIZOATE DIHYDRATE 2,4,6-TRIIODO-3,5-BIS(N-METHYLACETAMIDO)BENZOIC ACID methylglucamine metrizoate Lozomic acid METHYL 3,5-DIACETAMIDO-2,4,6-TRIIODOBENZOATE

2,4,6-triiodo-3,5-diacetamidobenzoicacid

3,5-bis(acetylamino)-2,4,6-triiodo-benzoicaci

3,5-diacetamido-2,4,6-triiodo-benzoicaci

amidotrizoate

diat

diatriazoate

3,5-BIS(ACETYLAMINO)-2,4,6-TRIIODOBENZOIC ACID

AMIDOTRIZOIC ACID

Diatrizoic

DIAZTRIZOICACID,ANHDYROUS

DIATRIZOICACID,ANHYDROUS

2,4,6-TRIIODO-3,5-DIACETAMIDOBENZOICACID(DIATRIZOICACID)

Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-

NSC 262168

3,5-diacetamino-2,4,6-triiodobenzoic acid

NSC-61815

3,5-Bis(acetamido)-2,4,6-triiodobenzoic Acid 3,5-Di(acetamido)-2,4,6-triiodobenzoic Acid

Diaztrizoate

Diatrizoic aci

diatrizoate

diatrizoesaure

odiston

triombrin

urografinacid

urogranoicacid

urotrast

3,5-BIS(ACETAMIDO)-2,4,6-TRIIODOBENZOIC ACID

Diatrizoic Acid &gt

DIATRIZOIC ACID USP/EP/BP

Diatrizoic acidQ: What is Diatrizoic acid Q: What is the CAS Number of Diatrizoic acid Q: What is the storage condition of Diatrizoic acid

Diatrizoic Acid, ≥ 98.0%

Diatrizoic acid

Amidotrizoic acid in methanol

C12207000 DiatrizoiCacid

Diatrizoic acid 100 μg/ml Acetonitrile

117-96-4

C11H19I3N2O4

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