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YS121

Product Name
YS121
CAS No.
916482-17-2
Chemical Name
YS121
Synonyms
YS121;YS121 Exclusive;HVJBWTVMRIOTEL-UHFFFAOYSA-N;Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-
CBNumber
CB92592892
Molecular Formula
C20H26ClN3O2S
Formula Weight
407.96
MOL File
916482-17-2.mol
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YS121 Property

Boiling point:
557.4±50.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
pka
3.04±0.21(Predicted)
form 
solution in acetate.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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N-Bromosuccinimide Price

Cayman Chemical
Product number
13665
Product name
YS-121
Purity
≥98%
Packaging
1mg
Price
$55
Updated
2024/03/01
Cayman Chemical
Product number
13665
Product name
YS-121
Purity
≥98%
Packaging
5mg
Price
$236
Updated
2024/03/01
Cayman Chemical
Product number
13665
Product name
YS-121
Purity
≥98%
Packaging
10mg
Price
$420
Updated
2024/03/01
Cayman Chemical
Product number
13665
Product name
YS-121
Purity
≥98%
Packaging
25mg
Price
$914
Updated
2024/03/01
AK Scientific
Product number
1614DC
Product name
2-[4-Chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyloctanoicacid
Packaging
10mg
Price
$564
Updated
2021/12/16
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YS121 Chemical Properties,Usage,Production

Description

Microsomal prostaglandin E2 synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever, and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. YS-121 is a dual inhibitor of mPGES-1 (IC50 = 3.9 μM) and 5-LO (IC50 = 4.1 μM). It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. Moreover, YS-121 (1.5 mg/kg, intraperitoneal) reduced pleural levels of PGE2 and LTB4 while blocking exudate formation and leukocyte infiltration in carrageenan-induced rat pleurisy. YS-121 has minor effects on COX-1 and COX-2, inhibiting these enzymes 24.8% and 38%, respectively, at 10 μM.

Definition

ChEBI: Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]- is a medium-chain fatty acid.

References

[1] koeberle a, zettl h, greiner c, et al. pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin e2 synthase-1 and 5-lipoxygenase[j]. journal of medicinal chemistry, 2008, 51(24): 8068-8076.
[2] mehrotra s, morimiya a, agarwal b, et al. microsomal prostaglandin e2 synthase‐1 in breast cancer: a potential target for therapy[j]. the journal of pathology, 2006, 208(3): 356-363.werz o, greiner c, koeberle a, et al. novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid[j]. journal of medicinal chemistry, 2008, 51(17): 5449-5453.koeberle a, rossi a, zettl h, et al. the molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2, 3-dimethylphenylamino) pyrimidin-2-ylthio) octanoic acid (ys121), a dual inhibitor of microsomal prostaglandin e2 synthase-1 and 5-lipoxygenase[j]. journal of pharmacology and experimental therapeutics, 2010, 332(3): 840-848.

YS121 Preparation Products And Raw materials

Raw materials

Preparation Products

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YS121 Suppliers

China 23 United States 3 Global 26
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

916482-17-2, YS121Related Search:

Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- YS-035 HYDROCHLORIDE YS 49 diperdipine

  • YS121
  • HVJBWTVMRIOTEL-UHFFFAOYSA-N
  • YS121 Exclusive
  • Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-
  • 916482-17-2