Physical Form
ChemicalBook > CAS DataBase List > 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

Physical Form
Product Name
3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
CAS No.
881386-01-2
Chemical Name
3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Synonyms
Apixaban Impurity 65;Apixaban Impurity 60;RRSYY(Fasoracetam)-4;3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one;3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone;3,3-dichloro-1-(4-nitrophenyl)2-2-piperidinone;2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-;2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-,881386-01-2;3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one
CBNumber
CB92594346
Molecular Formula
C11H10Cl2N2O3
Formula Weight
289.11
MOL File
881386-01-2.mol
More
Less

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Property

Boiling point:
520.2±50.0 °C(Predicted)
Density 
1.50
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly, Sonicated)
form 
Solid
pka
-7.38±0.40(Predicted)
color 
Light Yellow to Yellow
InChI
InChI=1S/C11H10Cl2N2O3/c12-11(13)6-1-7-14(10(11)16)8-2-4-9(5-3-8)15(17)18/h2-5H,1,6-7H2
InChIKey
KKVYXBZVPRSWHE-UHFFFAOYSA-N
SMILES
N1(C2=CC=C([N+]([O-])=O)C=C2)CCCC(Cl)(Cl)C1=O
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-M2357
Product name
3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Purity
99.73%
Packaging
10g
Price
$50
Updated
2021/12/16
Ambeed
Product number
A985233
Product name
3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Purity
97%
Packaging
25g
Price
$67
Updated
2021/12/16
aablocks
Product number
AA00GTWP
Product name
3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Purity
98%
Packaging
10g
Price
$87
Updated
2021/12/16
Crysdot
Product number
CD11035802
Product name
3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Purity
97%
Packaging
5g
Price
$90
Updated
2021/12/16
aablocks
Product number
AA00GTWP
Product name
3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Purity
98%
Packaging
25g
Price
$127
Updated
2021/12/16
More
Less

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Chemical Properties,Usage,Production

Physical Form

Light Yellow to Yellow Solid

Description

3, 3-dichloro-1 -(4-nitrophenyl) -2-piperidinone is an important pharmaceutical intermediate, as it can be used to prepare apixaban derivatives. Apixaban is a small molecular selective FXa inhibitor of pyrazole derivatives. Similar to Rivaroxaban, apixaban has two binding sites to Factor Xa, where 4-methoxyphenyl in the apixaban structure partially binds the S1 pocket of Factor Xa and aryllactam partially binds the S4 pocket of Factor Xa.

Uses

3,??3-??Dichloro-??1-??(4-??nitrophenyl)??piperidin-??2-??one is a reagent used in the preparation of novel tetrahydropyrazolopyridone derivatives. Used in the preparation of anti-coagulants.

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Suppliers

China 123 India 7 United States 3 Global 133
Beijing Whale Technology Corporation Ltd.
Tel
010-83694934 13671295325
Email
sales@whalecorporation.com
Country
China
ProdList
126
Advantage
58
Jinan Billion Pharmaceutical Technology Co., Ltd
Tel
+86-15589952515 +86-15589952515
Email
80912934@qq.com
Country
China
ProdList
56
Advantage
58
Shanghai Sagachem Co., Ltd.
Tel
13816115801
Email
raochenaone@126.com
Country
China
ProdList
193
Advantage
58
Jilin Lianben Technology Development Co., Ltd
Tel
15688981295
Fax
0432-62601618
Email
wangyifei@lianben.com
Country
China
ProdList
46
Advantage
58
ZHIWE CHEMTECH CO LTD
Tel
021-20221225 13917446399
Fax
QQ:115820162
Email
sales@zhiwe.net
Country
China
ProdList
578
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Jinan Chenghui Shuangda biological Co., LTD
Tel
0531-58897003 15550412551
Fax
0531-58897003
Email
market@jnchsd.com
Country
China
ProdList
217
Advantage
62
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9900
Advantage
58
Suzhou Carbonwell Pharma-Tech Co., Ltd
Tel
0512-0512-88981216 13776013740
Email
1320558046@qq.com
Country
China
ProdList
72
Advantage
58
Acesys Pharmatech
Tel
18860950986
Email
tangmanman@zenjipharma.com
Country
China
ProdList
1735
Advantage
55
Shanghai Arbor Chemical Co., Ltd.
Tel
021-021-60451683 15021268886
Fax
+86-21-60451682
Email
sales@arborchemical.com
Country
China
ProdList
922
Advantage
55
Suzhou lipin Chemical Co., Ltd
Tel
0512-0512-67509664 19888480046
Country
China
ProdList
121
Advantage
58
Taizhou Tongxin Bio-Tech Co., Ltd
Tel
0523-18601685-898 18652728585
Email
sales@allyrise.com
Country
China
ProdList
2751
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17993
Advantage
56
Hotechem Shanghai Co., Ltd.,
Tel
021-34621078 13120882795
Fax
021-34622517
Email
465106944@qq.com
Country
China
ProdList
859
Advantage
56
Guangzhou Ciming Biological Technology Co., Ltd.
Tel
020-38082199,29065168,38082986,29878298,29866629,4000192398
Fax
+86 (20)38082986
Country
China
ProdList
831
Advantage
60
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4901
Advantage
55
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
sales@chemwill.com
Country
China
ProdList
1975
Advantage
58
Beijing Cooperate Pharmaceutical Co.,Ltd
Tel
+86-010-60279497 +86-15646567669
Fax
010-60279497
Email
sales01@cooperate-pharm.com
Country
China
ProdList
137
Advantage
58
Jinan Jianfeng Chemical Co., Ltd.
Tel
0531-88110457 15562555968
Email
info@pharmachemm.com
Country
China
ProdList
174
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
9242
Advantage
58
Henan Jiuhua Biological Technology Co., Ltd.
Tel
15738884691 153248764872949584887 237654463
Fax
0371-55320919
Email
jiuhuabiochem@163.com
Country
China
ProdList
2755
Advantage
58
CHENGHUI PHARMACEUTICAL GROUP LTD
Tel
0531-58897070 15254140813
Fax
0531-58897046
Email
market@jnchsd.com
Country
China
ProdList
216
Advantage
58
Aikon International Limited
Tel
025-66028182 18112977050
Fax
(3)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
15820
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 18016230971
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
24971
Advantage
58
Alchemist-pharm chemical Technology Co. Ltd.
Tel
0371-67991738 13783628208
Fax
QQ 412703949
Email
carl@alchemist-pharm.com
Country
China
ProdList
1877
Advantage
58
Haohong (Qihe) Medical Technology Co., LTD
Tel
18068541569 18660163165
Fax
0519-85551569
Email
sale@inyelchem.com
Country
China
ProdList
194
Advantage
58
Hubei Changrun Biomedical Technology Co., Ltd.
Tel
027-63496417 13007129042
Fax
13476107660
Email
3294393103@qq.com
Country
China
ProdList
310
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-037163312495,13303845143 13303845143
Fax
QQ3001379618
Email
3001379618@qq.com
Country
China
ProdList
9942
Advantage
58
Abydos Scientific
Tel
025-84767922 18936879710
Email
sales@abydoscientific.com
Country
China
ProdList
1011
Advantage
58
Wuhan Boye Technology Development Co., Ltd.
Tel
027-81625225 15377010747
Fax
027-81625225
Email
hui@boyechemicals.com
Country
China
ProdList
482
Advantage
58
Chongqing Genco Pharmaceutical Co.,Ltd
Tel
023-88654579 13637703915
Fax
375097861
Email
375097861@qq.com
Country
China
ProdList
297
Advantage
58
Shenzhen Botel Biotechnology Co. Ltd.
Tel
0755-22202135 13316968096
Email
1979313431@qq.com
Country
China
ProdList
8065
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55055611 18137792234
Fax
QQ：3002694073
Email
3002694073@qq.com
Country
China
ProdList
10098
Advantage
58
Henan Alfa Chemical Co., Ltd
Tel
+8618339805032
Email
alfa4@alfachem.cn
Country
China
ProdList
13039
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25363
Advantage
58
sgtlifesciences pvt ltd
Tel
+8617013299288
Email
dj@sgtlifesciences.com
Country
China
ProdList
12382
Advantage
58
AFINE CHEMICALS LIMITED
Tel
+86-0571-85134551
Fax
008657185134895
Email
info@afinechem.com
Country
China
ProdList
15396
Advantage
58
Jinjiangchem Corporation
Tel
512-50133713
Email
sales@jinjiangchem.com
Country
CHINA
ProdList
1072
Advantage
58
Wuhan Boye Science And Technology Development Co., Ltd.
Tel
27-81625225 +8615387090420
Fax
86-27-81625225
Email
sumihu@boyechemicals.com
Country
CHINA
ProdList
215
Advantage
58
Guangzhou Dreampharm Biotechnology Co., Ltd.
Tel
020-36607679 17825480238
Fax
QQ 3008233717
Email
3008233717@qq.com
Country
China
ProdList
9843
Advantage
12
Jinan Ruisi Pharmaceutical Technology Co., LTD
Tel
0531-69900633 18340090523
Email
changyuan20@163.com
Country
China
ProdList
1839
Advantage
58
Shandong chuangyingchemical Co., Ltd.
Tel
18853181302
Email
sale@chuangyingchem.com
Country
CHINA
ProdList
5909
Advantage
58
Jinan blalong chemical co. LTD
Tel
2710913286@.com
Email
1513643261@qq.com
Country
China
ProdList
14253
Advantage
58
Shanghai Yanze Chemical Co., Ltd.
Tel
021-13773155751 19901447308
Email
260924549@qq.com
Country
China
ProdList
8756
Advantage
58
Synbest Biotech(Hangzhou) Co., Ltd
Tel
86-571-88737065
Email
sales@synbestech.com
Country
CHINA
ProdList
171
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49323
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 15093356674;
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29826
Advantage
58
Beijing Haite lesk Technology Co., Ltd
Tel
15210893940; 15116916250
Fax
QQ: 237008221
Email
chemistryliu@163.com
Country
China
ProdList
7327
Advantage
58
Nanjing bojida Pharmaceutical Technology Co., Ltd
Tel
18762407961
Email
704079339@qq.com
Country
China
ProdList
575
Advantage
58
More
Less

View Lastest Price from 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one manufacturers

Speranza Chemical Co., Ltd.
Product
2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)- 881386-01-2
Price
US $20.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20 tons
Release date
2019-12-24
Jinan Million Pharmaceutical Co., Ltd
Product
3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one 881386-01-2
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1200KG/M
Release date
2023-08-15
Shanghai CRM New Material Technology Co., LTD
Product
3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone 881386-01-2
Price
US $10.00-15.00/g
Min. Order
10g
Purity
99%
Supply Ability
10t
Release date
2022-09-20

881386-01-2, 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-oneRelated Search:

Apixaban Impurity 16 (4,4'‐didodecyl‐2,2'‐ bithiophene‐5,5'‐ diyl)bis(triMethylstann ane) Apixaban-13C-D3 Apixaban IMpurity 5 (BMS-591329-01) Apixaban IMpurity(BMS-778960-01) ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate 1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide Apixaban Apixaban IMpurity( Apixaban IMpurity 6 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid Apixaban IMpurity 3 Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester ETHYL (2E)-CHLORO[(4-CHLOROPHENYL)HYDRAZONO]ACETATE 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide

  • 3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone
  • 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one
  • 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one
  • 2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-
  • Apixaban Impurity 60
  • Apixaban Impurity 65
  • 3,3-dichloro-1-(4-nitrophenyl)2-2-piperidinone
  • 2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-,881386-01-2
  • RRSYY(Fasoracetam)-4
  • 881386-01-2