3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

ChemicalBook > CAS DataBase List > 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

Physical Form

Product Name: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
CAS No.: 881386-01-2
Chemical Name: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Synonyms: Apixaban Impurity 65;Apixaban Impurity 60;RRSYY(Fasoracetam)-4;3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one;3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone;3,3-dichloro-1-(4-nitrophenyl)2-2-piperidinone;2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-;2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-,881386-01-2;3,3-Dichloro-1-(4-Nitrophenyl)piperidin-2-one2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl);3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one
CBNumber: CB92594346
Molecular Formula: C11H10Cl2N2O3
Formula Weight: 289.11
MOL File: 881386-01-2.mol

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3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Property

Boiling point:: 520.2±50.0 °C(Predicted)
Density: 1.50
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: -7.38±0.40(Predicted)
color: Light Yellow to Yellow
InChI: InChI=1S/C11H10Cl2N2O3/c12-11(13)6-1-7-14(10(11)16)8-2-4-9(5-3-8)15(17)18/h2-5H,1,6-7H2
InChIKey: KKVYXBZVPRSWHE-UHFFFAOYSA-N
SMILES: N1(C2=CC=C([N+]([O-])=O)C=C2)CCCC(Cl)(Cl)C1=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-M2357
Product name: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Purity: 99.73%
Packaging: 10g
Price: $50
Updated: 2021/12/16

Ambeed

Product number: A985233
Product name: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Purity: 97%
Packaging: 25g
Price: $67
Updated: 2021/12/16

aablocks

Product number: AA00GTWP
Product name: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Purity: 98%
Packaging: 10g
Price: $87
Updated: 2021/12/16

Crysdot

Product number: CD11035802
Product name: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Purity: 97%
Packaging: 5g
Price: $90
Updated: 2021/12/16

aablocks

Product number: AA00GTWP
Product name: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Purity: 98%
Packaging: 25g
Price: $127
Updated: 2021/12/16

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3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Chemical Properties,Usage,Production

Physical Form

Light Yellow to Yellow Solid

Description

3, 3-dichloro-1 -(4-nitrophenyl) -2-piperidinone is an important pharmaceutical intermediate, as it can be used to prepare apixaban derivatives. Apixaban is a small molecular selective FXa inhibitor of pyrazole derivatives. Similar to Rivaroxaban, apixaban has two binding sites to Factor Xa, where 4-methoxyphenyl in the apixaban structure partially binds the S1 pocket of Factor Xa and aryllactam partially binds the S4 pocket of Factor Xa.

Uses

3,??3-??Dichloro-??1-??(4-??nitrophenyl)??piperidin-??2-??one is a reagent used in the preparation of novel tetrahydropyrazolopyridone derivatives. Used in the preparation of anti-coagulants.

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one 881386-01-2
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1200KG/M
Release date: 2023-08-15

Speranza Chemical Co., Ltd.

Product: 2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)- 881386-01-2
Price: US $20.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20 tons
Release date: 2019-12-24

Shanghai CRM New Material Technology Co., LTD

Product: 3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone 881386-01-2
Price: US $10.00-15.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 10t
Release date: 2022-09-20

881386-01-2, 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-oneRelated Search:

Apixaban Impurity 16 (4,4'‐didodecyl‐2,2'‐ bithiophene‐5,5'‐ diyl)bis(triMethylstann ane) Apixaban-13C-D3 Apixaban IMpurity 5 (BMS-591329-01) Apixaban IMpurity(BMS-778960-01) ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate 1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide Apixaban Apixaban IMpurity( Apixaban IMpurity 6 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid Apixaban IMpurity 3 Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester ETHYL (2E)-CHLORO[(4-CHLOROPHENYL)HYDRAZONO]ACETATE 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide

3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone

3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one

3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one

2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-

Apixaban Impurity 60

Apixaban Impurity 65

3,3-dichloro-1-(4-nitrophenyl)2-2-piperidinone

2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-,881386-01-2

RRSYY(Fasoracetam)-4

3,3-Dichloro-1-(4-Nitrophenyl)piperidin-2-one2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)

881386-01-2