Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate
- Product Name
- Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate
- CAS No.
- 473927-63-8
- Chemical Name
- Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate
- Synonyms
- Apixaban I;Apixaban int;Apixaban Impurity O;Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]acetate;Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate;Acetic acid, chloro[(4-methoxyphenyl)hydrazono]-, ethyl este...;Ethyl (2Z)-2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]acetate;ethyl (2Z)-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate;Acetic acid, chloro[(4-Methoxyphenyl)hydrazono]-, ethyl ester, (2Z)-;(2Z)-2-Chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]acetic acid ethyl ester
- CBNumber
- CB32514108
- Molecular Formula
- C11H13ClN2O3
- Formula Weight
- 256.69
- MOL File
- 473927-63-8.mol
Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate Property
- Boiling point:
- 349.0±44.0 °C(Predicted)
- Density
- 1.23
- vapor pressure
- 0.008Pa at 25℃
- pka
- 11.63±0.10(Predicted)
- InChI
- InChI=1S/C11H13ClN2O3/c1-3-17-11(15)10(12)14-13-8-4-6-9(16-2)7-5-8/h4-7,13H,3H2,1-2H3/b14-10-
- InChIKey
- ATNPZEGMKLGIFA-UVTDQMKNSA-N
- SMILES
- C(OCC)(=O)/C(/Cl)=N/NC1=CC=C(OC)C=C1
- LogP
- 2.53
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H331Toxic if inhaled
H341Suspected of causing genetic defects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CD12069983
- Product name
- (Z)-Ethyl2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- 473927638
- Product name
- (Z)-Ethyl2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
- Packaging
- 10g
- Price
- $523.8
- Updated
- 2021/12/16
- Product number
- CD12069983
- Product name
- (Z)-Ethyl2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $540
- Updated
- 2021/12/16
Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate Chemical Properties,Usage,Production
Uses
Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical and pharmaceutical production processes.
Synthesis
Preparation of ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate To p-anisidine (16 g, 0.129 mol) in conc. HCL (40 mL), 100 mL) H2O, cooled to -5?? C. and sodium nitrite (9.4 g, 0.136 mol) in H2O (60 mL) was added. The reaction mixture was stirred at -5?? C. for 20 min and a mixture of ethylchloroacetoacetate (22 g, 0.133 mol), ethanol (100 mL), sodiumacetate (32 g, 0.389 mmol), and H2O (400 mL) was added. The reaction was allowed to warm up to room temperature and stirred for 2h. The product precipitated as a black solid. It was filtered and dried (30 g). 1H-NMR (CDCl3) |? 8.28 (s, 1H), 7.18 (d, 2H), 6.90 (d, 2H), 4.41 (q, 2H), 3.80 (s, 3H), 1.42 (t, 3H) ppm.
Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate manufacturers
- Product
- Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate 473927-63-8
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1200KG/M
- Release date
- 2023-08-15
- Product
- Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate 473927-63-8
- Price
- US $30.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 300MT/year
- Release date
- 2019-12-12
- Product
- Ethyl(2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate 473927-63-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- g/kg/T
- Release date
- 2019-12-18