1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE

Product Name: 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE
CAS No.: 385425-15-0
Chemical Name: 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE
Synonyms: Apixaban II;RSYY（Lifitegrast)-20;Piperidinone,1-(4-iodophenyl)-;1-(4-Iodophenyl)-2-piperidinone;2-Piperidinone,1-(4-iodophenyl)-;1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE;1-(4-iodophenyl)piperidine-2-ketone;1-(4-iodophenyl)hexahydropyridin-2-one;385425-15-0
CBNumber: CB6841043
Molecular Formula: C11H12INO
Formula Weight: 301.12
MOL File: 385425-15-0.mol

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1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE Property

Boiling point:: 446.1±28.0 °C(Predicted)
Density: 1.670
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: -0.43±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C11H12INO/c12-9-4-6-10(7-5-9)13-8-2-1-3-11(13)14/h4-7H,1-3,8H2
InChIKey: OYDSTJMVOOOYDW-UHFFFAOYSA-N
SMILES: N1(C2=CC=C(I)C=C2)CCCCC1=O

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B448805
Product name: 1-(4-Iodophenyl)piperidin-2-one
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 056492
Product name: 1-(4-Iodophenyl)piperidin-2-one
Purity: >95%
Packaging: 1g
Price: $85
Updated: 2021/12/16

Matrix Scientific

Product number: 056492
Product name: 1-(4-Iodophenyl)piperidin-2-one
Purity: >95%
Packaging: 5g
Price: $161
Updated: 2021/12/16

AK Scientific

Product number: Y6559
Product name: 1-(4-Iodophenyl)piperidin-2-one
Packaging: 10g
Price: $212
Updated: 2021/12/16

Matrix Scientific

Product number: 056492
Product name: 1-(4-Iodophenyl)piperidin-2-one
Purity: >95%
Packaging: 500mg
Price: $40
Updated: 2021/12/16

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1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE Chemical Properties,Usage,Production

Synthesis

4509-90-4

540-37-4

385425-15-0

General steps: 1. triethylamine (31.10 g, 307.38 mmol) was added to a solution of 4-iodoaniline (30.0 g, 136.98 mmol) in tetrahydrofuran (800 mL) under nitrogen protection. 2. The reaction mixture was cooled to 0 °C, then a solution of 5-bromovaleryl chloride (32.7 g, 163.90 mmol) in tetrahydrofuran (200 mL) was slowly added dropwise over 30 min. 3. After the dropwise addition was completed, the reaction mixture was brought to room temperature and stirred for 16 hours. 4. After the reaction was complete, the mixture was cooled to 0 °C again and potassium tert-butoxide (46.0 g, 410 mmol) was slowly added. 5. The reaction mixture was brought to room temperature and stirred for 18 hours. 6. 6. After completion of the reaction, the solvent was removed by concentration under reduced pressure to give a thick oily substance. 7. The pH was adjusted to 2.0 with 3N hydrochloric acid solution and extracted with ethyl acetate (3 x 500 mL). 8. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the crude product. 9. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane, 0%-100%) to afford 1-(4-iodophenyl)piperidin-2-one (20.0 g, yield 48.5%) as an off-white solid. Characterization data: Melting point: 108-110°C. 1H NMR (400 MHz, CDCl3) δ: 1.93-1.95 (m, 4H), 2.55 (t, J = 6.2 Hz, 2H), 3.62 (t, J = 5.2 Hz, 2H), 7.02 (d, J = 8.4 Hz, 2H), 7.70 (d, J = 8.4 Hz, 2H). IR (KBr) υ: 3256, 3049, 2936, 2864, 1634, 1576, 1482, 1434, 1164, 1000, 819, 709 cm-1. MS: 302 (M + 1).

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 22, p. 5339 - 5356
[2] Patent: US2003/232804, 2003, A1. Location in patent: Page 94
[3] Patent: US2017/50964, 2017, A1. Location in patent: Paragraph 0699
[4] Patent: WO2010/30983, 2010, A2. Location in patent: Page/Page column 28

1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE Suppliers

China 102 India 12 United States 8 Global 122

Neostar United (Changzhou) Industrial Co., Ltd.

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View Lastest Price from 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE 385425-15-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-05-20

Speranza Chemical Co., Ltd.

Product: 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE 385425-15-0
Price: US $56.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 25MT/year
Release date: 2020-06-10

Henan Aochuang Chemical Co.,Ltd.

Product: 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE 385425-15-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

385425-15-0, 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONERelated Search:

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Apixaban IMpurity(BMS-591329-01) Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester Apixaban Impurity 8 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Apixaban IMpurity 2 ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one 1-(4-Nitrophenyl)-2-piperidinone 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-[4-(5-methyl-2-oxo-1-piperidinyl)phenyl]-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxamide Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate ethyl 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 1-(4-Hydroxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide Apixaban IMpurity 5 (BMS-591329-01) 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE 1-(2-FLUORO-4-IODO-PHENYL)-PIPERIDIN-2-ONE 8-(2-CHLORO-4-IODOPHENYL)-8-AZASPIRO[4.5]DECANE-7,9-DIONE

1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE

Apixaban II

2-Piperidinone,1-(4-iodophenyl)-

1-(4-Iodophenyl)-2-piperidinone

1-(4-iodophenyl)piperidine-2-ketone

RSYY（Lifitegrast)-20

1-(4-iodophenyl)hexahydropyridin-2-one

Piperidinone,1-(4-iodophenyl)-

385425-15-0

C11H12INO