3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Description References- Product Name
- 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
- CAS No.
- 503615-03-0
- Chemical Name
- 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
- Synonyms
- 5,6-Dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-2(1H)-pyridinone;TECO-011;Apixaban int3;PR-204 impurity;Apixaban Impurity 19;Apixaban Intermediate3;Apixaban related impurities 1;2-Naphthalenecarboxylicacid,12-amino-,methylester;5-morpholino-1-(4-nitrophenyl)-2,3-dihydropyridin-6-one;Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
- CBNumber
- CB62516219
- Molecular Formula
- C15H17N3O4
- Formula Weight
- 303.31
- MOL File
- 503615-03-0.mol
3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Property
- Boiling point:
- 506.5±50.0 °C(Predicted)
- Density
- 1.356
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 3.11±0.20(Predicted)
- color
- Light Yellow
- InChI
- InChI=1S/C15H17N3O4/c19-15-14(16-8-10-22-11-9-16)2-1-7-17(15)12-3-5-13(6-4-12)18(20)21/h2-6H,1,7-11H2
- InChIKey
- LBFAEOWNWSDWRZ-UHFFFAOYSA-N
- SMILES
- C1(=O)N(C2=CC=C([N+]([O-])=O)C=C2)CCC=C1N1CCOCC1
N-Bromosuccinimide Price
- Product number
- M725125
- Product name
- 3-(Morpholinyl)-N-(4-nitrophenyl)-5,6-dihydropyridin-2-one
- Packaging
- 5g
- Price
- $745
- Updated
- 2021/12/16
- Product number
- CHM0389374
- Product name
- 3-MORPHOLINO-1-(4-NITROPHENYL)-5,6-DIHYDROPYRIDIN-2(1H)-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.13
- Updated
- 2021/12/16
- Product number
- CS-M1442
- Product name
- 3-morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
- Purity
- 99.68%
- Packaging
- 100g
- Price
- $780
- Updated
- 2021/12/16
- Product number
- CS-M1442
- Product name
- 3-morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
- Purity
- 99.68%
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-M1442
- Product name
- 3-morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
- Purity
- 99.68%
- Packaging
- 10g
- Price
- $125
- Updated
- 2021/12/16
3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Chemical Properties,Usage,Production
Description
3-(4-Morpholinyl)-1-(4-nitrophenyl)-5, 6-dihydro-2(1H)-pyridinone is the intermediate for the synthesis of apixaban, which is an anticoagulant for the treatment of venous thromboembolic events.
References
Chao, H. E., et al. "Synthesis of Apixaban." Chinese Journal of Pharmaceuticals (2014).
https://en.wikipedia.org/wiki/Apixaban
Uses
3-(Morpholinyl)-N-(4-nitrophenyl)-5,6-dihydropyridin-2-one is a reagent in the synthesis of 4,5-dehydro Apixaban (D229385) an impurity of Apixaban (A726700), a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation
3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one manufacturers
- Product
- 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 503615-03-0
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1200KG/M
- Release date
- 2023-08-15
- Product
- 3-(4-Morpholinyl)-1-(4-nitrophenyl)-5,6-dihydro-2(1H)-pyridinone 503615-03-0
- Price
- US $25.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20 tons
- Release date
- 2019-12-24
- Product
- 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 503615-03-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 2000
- Release date
- 2024-12-11