1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

Product Name: 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
CAS No.: 1267610-26-3
Chemical Name: 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
Synonyms: 1-(4-aMinophenyl)-3-Morpholino-5,6-dihydropyridin-2(1H)-one;Apixaban intA;Apixaban Impurity S;Apixaban Impurity 47;Apixaban Impurity 50;Apixaba inretMediate A;Apixaban related impurities 2;4-Pyrimidinol,2-methoxy-12-methyl-;1-(4-aminophenyl)-5,6-dihydro-3-(4-;1-(4-Aminophenyl)-5,6-Dihydro-3-(4-Morpholinyl)-2(1H)-Py
CBNumber: CB52660744
Molecular Formula: C15H19N3O2
Formula Weight: 273.33
MOL File: 1267610-26-3.mol

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1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Property

Melting point:: >246°C (dec.)
Boiling point:: 491.5±45.0 °C(Predicted)
Density: 1.277±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 4.96±0.10(Predicted)
color: Off-White to Pale Beige
InChI: InChI=1S/C15H19N3O2/c16-12-3-5-13(6-4-12)18-7-1-2-14(15(18)19)17-8-10-20-11-9-17/h2-6H,1,7-11,16H2
InChIKey: YUGIGSPFTMLIMA-UHFFFAOYSA-N
SMILES: C1(=O)N(C2=CC=C(N)C=C2)CCC=C1N1CCOCC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A637898
Product name: 1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone
Packaging: 1g
Price: $425
Updated: 2021/12/16

TRC

Product number: A637898
Product name: 1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone
Packaging: 50g
Price: $605
Updated: 2021/12/16

AK Scientific

Product number: Z3503
Product name: 1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone
Packaging: 25mg
Price: $85
Updated: 2021/12/16

Crysdot

Product number: CD11303316
Product name: 1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
Purity: 95+%
Packaging: 5g
Price: $100
Updated: 2021/12/16

Ambeed

Product number: A431106
Product name: 1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
Purity: 95%
Packaging: 25g
Price: $105
Updated: 2021/12/16

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1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Chemical Properties,Usage,Production

Uses

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone is an intermediate in the synthesis of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.

Synthesis

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production In the process.

Synthesis

Add 25L of water and 25L of methanol to the 500L reactor, add 2.5kg of compound (I) and 250g of Raney cobalt under stirring, raise the temperature to 40-50 ??C, slowly add 2.0kg of hydrazine hydrate (content 80%), keep warm 60-70 ??C, reaction for 3h, the reaction was completed, filtered with diatomaceous earth, concentrated solvent was removed, and MTBE was added to the filter cake.2.20 kg of a white solid were obtained with a yield of 98% and a purity of 99.8%.

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Suppliers

China 241 India 17 United States 9 Global 267

Jinan Jianfeng Chemical Co., Ltd.

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Jiangsu Vcare PharmaTech Co., Ltd.

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Jinan Jianfeng Chemical Co.,Ltd.

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Jinan zhongdaoanran chemical Co;Ltd

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ChemFuture PharmaTech (Jiangsu) Ltd

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View Lastest Price from 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone manufacturers

Speranza Chemical Co., Ltd.

Product: 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1267610-26-3
Price: US $25.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20 tons
Release date: 2019-12-24

Jinan Million Pharmaceutical Co., Ltd

Product: 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1267610-26-3
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1200KG/M
Release date: 2023-08-15

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Apixaban Impurity 50 1267610-26-3
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-06-05

1267610-26-3, 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinoneRelated Search:

Apixaban Impurity 16 Apixaban IMpurity 2 Apixaban IMpurity 3 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate Apixaban Impurity 11 Apixaban IMpurity(BMS-591329-01) Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Nitrophenyl)-2-piperidinone Apixaban Apixaban Impurity BMS-591329

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

1-(4-aMinophenyl)-3-Morpholino-5,6-dihydropyridin-2(1H)-one

2(1H)-Pyridinone, 1-(4-aMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-

Apixaba inretMediate A

Apixaban Impurity S

Apixaban Impurity 47

Apixaban intA

Apixaban related impurities 2

Apixaban Impurity 50

ethyl 7-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate，1-(4-AMinophenyl)-5,6-dihydro-3-(4- Morpholinyl)-2(1h)-pyridinone

-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridi...

2(1H)-Pyridinone,1-Chemicalbook(4-aMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-

1-(4-aminophenyl)-5,6-dihydro-3-(4-

4-Pyrimidinol,2-methoxy-12-methyl-

1-(4-Aminophenyl)-5-Morpholin-4-yl-2,3-Dihydropyridin-6-One

5.6-Dihydro-3-(4-morpholinyl)-1-(4-aminophenyl)-2(1H)-pyridinone

1-(4-Aminophenyl)-3-(4-morpholinyl)-5,6-dihydro-2(1H)-pyridinone

1-(4-Amino Phenyl)-5,6-Dihydro-3-Morpholino-Pyridin-2(1H)-one

1-(4-aminophenyl)-5, 6-dihydro-3 -(4-morpholine)-2(1H) -pyridone

1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridone

1-(4-Aminophenyl)-5,6-Dihydro-3-(4-Morpholinyl)-2(1H)-Py

1267610-26-3

267610-26-3