ChemicalBook > CAS DataBase List > 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

Product Name
1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
CAS No.
1267610-26-3
Chemical Name
1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
Synonyms
1-(4-aMinophenyl)-3-Morpholino-5,6-dihydropyridin-2(1H)-one;Apixaban intA;Apixaban Impurity S;Apixaban Impurity 47;Apixaban Impurity 50;Apixaba inretMediate A;Apixaban related impurities 2;4-Pyrimidinol,2-methoxy-12-methyl-;1-(4-aminophenyl)-5,6-dihydro-3-(4-;1-(4-Aminophenyl)-5,6-Dihydro-3-(4-Morpholinyl)-2(1H)-Py
CBNumber
CB52660744
Molecular Formula
C15H19N3O2
Formula Weight
273.33
MOL File
1267610-26-3.mol
More
Less

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Property

Melting point:
>246°C (dec.)
Boiling point:
491.5±45.0 °C(Predicted)
Density 
1.277±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
4.96±0.10(Predicted)
color 
Off-White to Pale Beige
InChI
InChI=1S/C15H19N3O2/c16-12-3-5-13(6-4-12)18-7-1-2-14(15(18)19)17-8-10-20-11-9-17/h2-6H,1,7-11,16H2
InChIKey
YUGIGSPFTMLIMA-UHFFFAOYSA-N
SMILES
C1(=O)N(C2=CC=C(N)C=C2)CCC=C1N1CCOCC1
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
A637898
Product name
1-​(4-​Aminophenyl)​-​5,​6-​dihydro-​3-​(4-​morpholinyl)​-​2(1H)​-​pyridinone
Packaging
1g
Price
$425
Updated
2021/12/16
TRC
Product number
A637898
Product name
1-​(4-​Aminophenyl)​-​5,​6-​dihydro-​3-​(4-​morpholinyl)​-​2(1H)​-​pyridinone
Packaging
50g
Price
$605
Updated
2021/12/16
AK Scientific
Product number
Z3503
Product name
1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone
Packaging
25mg
Price
$85
Updated
2021/12/16
Crysdot
Product number
CD11303316
Product name
1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
Purity
95+%
Packaging
5g
Price
$100
Updated
2021/12/16
Ambeed
Product number
A431106
Product name
1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
Purity
95%
Packaging
25g
Price
$105
Updated
2021/12/16
More
Less

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Chemical Properties,Usage,Production

Uses

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone is an intermediate in the synthesis of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.

Synthesis

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production In the process.

Synthesis


Add 25L of water and 25L of methanol to the 500L reactor, add 2.5kg of compound (I) and 250g of Raney cobalt under stirring, raise the temperature to 40-50 ??C, slowly add 2.0kg of hydrazine hydrate (content 80%), keep warm 60-70 ??C, reaction for 3h, the reaction was completed, filtered with diatomaceous earth, concentrated solvent was removed, and MTBE was added to the filter cake.2.20 kg of a white solid were obtained with a yield of 98% and a purity of 99.8%.

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Suppliers

China 246 India 17 United States 10 Global 273
Jinan Jianfeng Chemical Co., Ltd.
Tel
0531-88110457; 18954159893
Email
demi@pharmachemm.com
Country
China
ProdList
180
Advantage
58
Jiangsu Vcare PharmaTech Co., Ltd.
Tel
13327700685
Fax
+86-25-58744115
Email
sales@vcarepharmatech.com
Country
China
ProdList
310
Advantage
61
Shandong kelikang drug co., ltd
Tel
0531-88113608 17854192669
Email
sales07@pharmachemm.com
Country
China
ProdList
83
Advantage
58
Suzhou Sino Rare Chemical Co., Ltd.
Tel
0512-62857507
Fax
+86-512-62857507
Email
sales@sinorarechem.com
Country
China
ProdList
995
Advantage
58
Jinan Billion Pharmaceutical Technology Co., Ltd
Tel
+86-15589952515 +86-15589952515
Email
80912934@qq.com
Country
China
ProdList
57
Advantage
58
Hefei Topway Biotechnology Co.,Ltd
Tel
0551-65326752 14755135869
Fax
0086-551-65326751
Email
xxhasym@163.com
Country
China
ProdList
62
Advantage
60
Jinan Jianfeng Chemical Co.,Ltd.
Tel
0531-0531-88110457 18954159739
Email
demi@pharmachemm.com
Country
China
ProdList
53
Advantage
58
Jinan zhongdaoanran chemical Co;Ltd
Tel
18678233466 18678233466
Email
122574856@qq.com
Country
China
ProdList
65
Advantage
58
EVERGREEN BIO-PHARM CO., LTD
Tel
15510277686
Email
sales@hxybio.com
Country
China
ProdList
229
Advantage
58
ChemFuture PharmaTech (Jiangsu) Ltd
Tel
5108538618
Fax
86 510 85386988-8017
Email
suger.wang@chemfuture.com
Country
China
ProdList
832
Advantage
65
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Jinan Chenghui Shuangda biological Co., LTD
Tel
0531-58897003 15550412551
Fax
0531-58897003
Email
market@jnchsd.com
Country
China
ProdList
217
Advantage
62
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5047
Advantage
50
Suzhou Carbonwell Pharma-Tech Co., Ltd
Tel
0512-0512-88981216 13776013740
Email
1320558046@qq.com
Country
China
ProdList
72
Advantage
58
Cangzhou Senary Chemical Science-tech Co., Ltd
Tel
+86-317-3563899
Fax
+86-317-3563199
Email
trade@senary.com
Country
China
ProdList
98
Advantage
56
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Ningbo Taikang Chemical Co., Ltd.
Tel
0574-87365517 18074210286
Fax
87367735
Email
sales@taikangchem.com
Country
China
ProdList
303
Advantage
58
Taizhou Tongxin Bio-Tech Co., Ltd
Tel
0523-18601685-898 18652728585
Email
sales@allyrise.com
Country
China
ProdList
2802
Advantage
60
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18097
Advantage
56
Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd.
Tel
19943855286
Fax
0371-53392065
Email
triz-4@trizpharma.cn
Country
China
ProdList
1954
Advantage
56
Shanghai Balmxy Pharmaceutical Co., Ltd
Tel
021-24206007 13764915196
Fax
86-021-23027023
Email
sales@balmxy.com
Country
China
ProdList
6779
Advantage
55
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4943
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10274
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11662
Advantage
59
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Hotechem Shanghai Co., Ltd.,
Tel
021-34621078 13120882795
Fax
021-34622517
Email
465106944@qq.com
Country
China
ProdList
857
Advantage
56
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-66023220 0086-15250997978
Fax
025-58362220
Email
1511893459@qq.com
Country
China
ProdList
7892
Advantage
55
FarmaSino Pharmaceuticals (Anhui) Co.,Ltd.
Tel
+86-18512541987
Fax
0555-5963572
Email
hll@farmasino.com
Country
China
ProdList
241
Advantage
60
Anqing CHICO Pharmaceutical Co., Ltd.
Tel
13585175604
Fax
+86-25-52261140
Email
sales@chicopharm.com
Country
China
ProdList
492
Advantage
65
Wuhan Kai Lun new material Chemical Co Ltd
Tel
025-87787262
Fax
025-87787262
Country
China
ProdList
496
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
INTERCHEMIE NANJING PHARMATECH CO., LTD
Tel
13656237714 13656237714
Fax
0512-65852853
Email
xiaokunfu@kyyykj.com
Country
China
ProdList
297
Advantage
55
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
5904
Advantage
65
Beijing Cooperate Pharmaceutical Co.,Ltd
Tel
+86-010-60279497 +86-15646567669
Fax
010-60279497
Email
sales01@cooperate-pharm.com
Country
China
ProdList
137
Advantage
58
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
Radiant Pharma & Tech. Co., Ltd
Tel
T:15050866711
Fax
QQ:2677337387
Email
wanglin.chen@radiant-pharma.com
Country
China
ProdList
466
Advantage
60
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Fax
0317-5106596
Email
sale@enkepharma.com
Country
China
ProdList
2007
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Henan Anky Chemical Technology Co., Ltd.
Tel
17836913271
Fax
0374-8348899
Email
3224305243@qq.com
Country
China
ProdList
2921
Advantage
58
Shanghai CR Corporation Limited
Tel
021-80270511; 4006653949
Fax
QQ: 2136646215
Email
fred.wen@crcorporation.cn
Country
China
ProdList
10044
Advantage
58
Shenzhen SUNGENING Bio-Medical Co., Ltd.
Tel
0755-28967200 13631290199
Fax
0755-28967200
Email
wxf@sungening.com
Country
China
ProdList
9578
Advantage
60
Jinan Winwind Biological Technology Co., Ltd
Tel
15153166971
Email
win-wind@hotmail.com
Country
China
ProdList
97
Advantage
58
LinkChem Co.,Ltd.
Tel
021-021-58950110 13124863828
Fax
021-20922272
Email
sales@linkchem.cn
Country
China
ProdList
2999
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718 +86-13336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29792
Advantage
60
More
Less

View Lastest Price from 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone manufacturers

Speranza Chemical Co., Ltd.
Product
1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1267610-26-3
Price
US $25.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20 tons
Release date
2019-12-24
Jinan Million Pharmaceutical Co., Ltd
Product
1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1267610-26-3
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1200KG/M
Release date
2023-08-15
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Apixaban Impurity 50 1267610-26-3
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-06-05

1267610-26-3, 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinoneRelated Search:

Apixaban Impurity 16 Apixaban IMpurity 2 Apixaban IMpurity 3 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate Apixaban Impurity 11 Apixaban IMpurity(BMS-591329-01) Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Nitrophenyl)-2-piperidinone Apixaban Apixaban Impurity BMS-591329

  • 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
  • 1-(4-aMinophenyl)-3-Morpholino-5,6-dihydropyridin-2(1H)-one
  • 2(1H)-Pyridinone, 1-(4-aMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-
  • Apixaba inretMediate A
  • Apixaban Impurity S
  • Apixaban Impurity 47
  • Apixaban intA
  • Apixaban related impurities 2
  • Apixaban Impurity 50
  • ethyl 7-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate，1-(4-AMinophenyl)-5,6-dihydro-3-(4- Morpholinyl)-2(1h)-pyridinone
  • -(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
  • 1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridi...
  • 2(1H)-Pyridinone,1-Chemicalbook(4-aMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-
  • 1-(4-aminophenyl)-5,6-dihydro-3-(4-
  • 4-Pyrimidinol,2-methoxy-12-methyl-
  • 1-(4-Aminophenyl)-5-Morpholin-4-yl-2,3-Dihydropyridin-6-One
  • 5.6-Dihydro-3-(4-morpholinyl)-1-(4-aminophenyl)-2(1H)-pyridinone
  • 1-(4-Aminophenyl)-3-(4-morpholinyl)-5,6-dihydro-2(1H)-pyridinone
  • 1-(4-Amino Phenyl)-5,6-Dihydro-3-Morpholino-Pyridin-2(1H)-one
  • 1-(4-aminophenyl)-5, 6-dihydro-3 -(4-morpholine)-2(1H) -pyridone
  • 1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridone
  • 1-(4-Aminophenyl)-5,6-Dihydro-3-(4-Morpholinyl)-2(1H)-Py
  • 1-(4-Amino-phenyl)-3-morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one
  • 1-(4-Aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one
  • 1267610-26-3
  • 267610-26-3