1-(4-Nitrophenyl)-2-piperidinone

Product Name: 1-(4-Nitrophenyl)-2-piperidinone
CAS No.: 38560-30-4
Chemical Name: 1-(4-Nitrophenyl)-2-piperidinone
Synonyms: Apixaban Impurity 64;1-(4-NP)-2-piperidinone;Carbamazepine Impurity 13;1-(4-Nitrophenyl)-2-piperidone;1-(4-Nitrophenyl)-2-piperidinone;2-Piperidinone, 1-(4-nitrophenyl)-;1-(4-Nitrophenyl)-2-piperidone >RSYY（Cyclobenzaprine hydrochloride)-4;1H-Pyrazole,3,5-bis(4-chlorophenyl)-4,11-dihydro-;1-(4-Nitrophenyl)piperidin-2-one?(ApixabanImpurity)
CBNumber: CB22521118
Molecular Formula: C11H12N2O3
Formula Weight: 220.22
MOL File: 38560-30-4.mol

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1-(4-Nitrophenyl)-2-piperidinone Property

Melting point:: 97.0 to 101.0 °C
Boiling point:: 480.9±28.0 °C(Predicted)
Density: 1.295
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly),Ethyl Acetate (Slightly)
pka: -3.84±0.20(Predicted)
form: Solid
color: Off-White to Yellow
InChI: InChI=1S/C11H12N2O3/c14-11-3-1-2-8-12(11)9-4-6-10(7-5-9)13(15)16/h4-7H,1-3,8H2
InChIKey: VPCQXIGQMFWXII-UHFFFAOYSA-N
SMILES: N1(C2=CC=C([N+]([O-])=O)C=C2)CCCCC1=O

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Safety

HS Code: 2933.79.1500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: N0975
Product name: 1-(4-Nitrophenyl)-2-piperidone
Purity: >98.0%(GC)
Packaging: 1g
Price: $46
Updated: 2025/07/31

TCI Chemical

Product number: N0975
Product name: 1-(4-Nitrophenyl)-2-piperidone
Purity: >98.0%(GC)
Packaging: 5g
Price: $175
Updated: 2024/03/01

TRC

Product number: N504505
Product name: 1-(4-Nitrophenyl)-2-piperidinone
Packaging: 5g
Price: $130
Updated: 2021/12/16

Chem-Impex

Product number: 43517
Product name: 1-(4-Nitrophenyl)-2-piperidone,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 1G
Price: $54.31
Updated: 2021/12/16

ChemScene

Product number: CS-M0372
Product name: 1-(4-Nitrophenyl)piperidin-2-one
Purity: 98.86%
Packaging: 5g
Price: $80
Updated: 2021/12/16

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1-(4-Nitrophenyl)-2-piperidinone Chemical Properties,Usage,Production

Uses

1-(4-Nitrophenyl)-2-piperidinone is used in the synthesis of inhibitors of blood coagulation factor Xa.

Synthesis

1039914-85-6

38560-30-4

5-Chloro-N-(4-nitrophenyl)pentanamide (72.3 g, 0.28 mol) was used as a raw material, which was mixed with K2CO3 and DMSO (360 mL) and the reaction was stirred at 80 °C for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into ice water (200 mL). The resulting precipitate was collected by filtration, washed with water and dried under reduced pressure to afford the target product 1-(4-nitrophenyl)-2-piperidone as a yellow powder (55.7 g, 89.6% yield). The melting point of the product was 96.4-98.3 °C; mass spectrum (ESI) m/z (%): 221.08 [M + H]+.

References

[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 21, p. 5646 - 5661
[2] Patent: CN104650072, 2016, B. Location in patent: Paragraph 0122; 0125; 0129; 0130
[3] Patent: US2017/15663, 2017, A1. Location in patent: Paragraph 0141
[4] Synthetic Communications, 2013, vol. 43, # 1, p. 72 - 79
[5] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 10, p. 2800 - 2810

1-(4-Nitrophenyl)-2-piperidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-Nitrophenyl)-2-piperidinone Suppliers

Americas 1 China 140 Europe 1 Germany 1 India 17 Japan 1 Switzerland 1 The Netherlands 1 United States 10 Global 173

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TOKYO CHEMICAL INDUSTRY CO., LTD.

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View Lastest Price from 1-(4-Nitrophenyl)-2-piperidinone manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Tris(2-pyridylmethyl)amine 38560-30-4
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-24

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-(4-Nitrophenyl)-2-piperidinone 38560-30-4
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-24

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Apixaban Impurity 64
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-06-05

38560-30-4, 1-(4-Nitrophenyl)-2-piperidinoneRelated Search:

Apixaban (4,4'‐didodecyl‐2,2'‐ bithiophene‐5,5'‐ diyl)bis(triMethylstann ane) 5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide Apixaban IMpurity 6 Apixaban IMpurity( 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide 1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester Apixaban IMpurity 3 Apixaban Impurity 12 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide Apixaban-13C-D3 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-[4-(5-methyl-2-oxo-1-piperidinyl)phenyl]-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

1-(4-Nitrophenyl)-2-piperidinone

1-(4-Nitrophenyl)-2-piperidone

1-(4-Nitrophenyl)-2-piperidone &gt

2-Piperidinone, 1-(4-nitrophenyl)-

Apixaban Impurity 64

1-(4-Nitrophenyl)piperidin-2-one?(ApixabanImpurity)

1H-Pyrazole,3,5-bis(4-chlorophenyl)-4,11-dihydro-

RSYY（Cyclobenzaprine hydrochloride)-4

1-(4-NP)-2-piperidinone

Carbamazepine Impurity 13

38560-30-4