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1-(4-Nitrophenyl)-2-piperidinone

Product Name
1-(4-Nitrophenyl)-2-piperidinone
CAS No.
38560-30-4
Chemical Name
1-(4-Nitrophenyl)-2-piperidinone
Synonyms
Apixaban Impurity 64;1-(4-NP)-2-piperidinone;Carbamazepine Impurity 13;1-(4-Nitrophenyl)-2-piperidone;1-(4-Nitrophenyl)-2-piperidinone;2-Piperidinone, 1-(4-nitrophenyl)-;1-(4-Nitrophenyl)-2-piperidone >RSYY（Cyclobenzaprine hydrochloride)-4;1H-Pyrazole,3,5-bis(4-chlorophenyl)-4,11-dihydro-;1-(4-Nitrophenyl)piperidin-2-one?(ApixabanImpurity)
CBNumber
CB22521118
Molecular Formula
C11H12N2O3
Formula Weight
220.22
MOL File
38560-30-4.mol
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1-(4-Nitrophenyl)-2-piperidinone Property

Melting point:
97.0 to 101.0 °C
Boiling point:
480.9±28.0 °C(Predicted)
Density 
1.295
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly),Ethyl Acetate (Slightly)
pka
-3.84±0.20(Predicted)
form 
Solid
color 
Off-White to Yellow
InChI
InChI=1S/C11H12N2O3/c14-11-3-1-2-8-12(11)9-4-6-10(7-5-9)13(15)16/h4-7H,1-3,8H2
InChIKey
VPCQXIGQMFWXII-UHFFFAOYSA-N
SMILES
N1(C2=CC=C([N+]([O-])=O)C=C2)CCCCC1=O
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Safety

HS Code 
2933.79.1500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
N0975
Product name
1-(4-Nitrophenyl)-2-piperidone
Purity
>98.0%(GC)
Packaging
1g
Price
$46
Updated
2025/07/31
TCI Chemical
Product number
N0975
Product name
1-(4-Nitrophenyl)-2-piperidone
Purity
>98.0%(GC)
Packaging
5g
Price
$175
Updated
2024/03/01
TRC
Product number
N504505
Product name
1-(4-Nitrophenyl)-2-piperidinone
Packaging
5g
Price
$130
Updated
2021/12/16
ChemScene
Product number
CS-M0372
Product name
1-(4-Nitrophenyl)piperidin-2-one
Purity
98.86%
Packaging
10g
Price
$134
Updated
2021/12/16
Chem-Impex
Product number
43517
Product name
1-(4-Nitrophenyl)-2-piperidone,≥98%(GC)
Purity
≥98%(GC)
Packaging
1G
Price
$54.31
Updated
2021/12/16
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1-(4-Nitrophenyl)-2-piperidinone Chemical Properties,Usage,Production

Uses

1-(4-Nitrophenyl)-2-piperidinone is used in the synthesis of inhibitors of blood coagulation factor Xa.

Synthesis

1039914-85-6

38560-30-4

5-Chloro-N-(4-nitrophenyl)pentanamide (72.3 g, 0.28 mol) was used as a raw material, which was mixed with K2CO3 and DMSO (360 mL) and the reaction was stirred at 80 °C for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into ice water (200 mL). The resulting precipitate was collected by filtration, washed with water and dried under reduced pressure to afford the target product 1-(4-nitrophenyl)-2-piperidone as a yellow powder (55.7 g, 89.6% yield). The melting point of the product was 96.4-98.3 °C; mass spectrum (ESI) m/z (%): 221.08 [M + H]+.

References

[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 21, p. 5646 - 5661
[2] Patent: CN104650072, 2016, B. Location in patent: Paragraph 0122; 0125; 0129; 0130
[3] Patent: US2017/15663, 2017, A1. Location in patent: Paragraph 0141
[4] Synthetic Communications, 2013, vol. 43, # 1, p. 72 - 79
[5] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 10, p. 2800 - 2810

1-(4-Nitrophenyl)-2-piperidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-Nitrophenyl)-2-piperidinone Suppliers

Americas 1 China 140 Europe 1 Germany 1 India 17 Japan 1 Switzerland 1 The Netherlands 1 United States 10 Global 173
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
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View Lastest Price from 1-(4-Nitrophenyl)-2-piperidinone manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Tris(2-pyridylmethyl)amine 38560-30-4
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-24
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
1-(4-Nitrophenyl)-2-piperidinone 38560-30-4
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-24
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Apixaban Impurity 64
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-06-05

38560-30-4, 1-(4-Nitrophenyl)-2-piperidinoneRelated Search:

Apixaban (4,4'‐didodecyl‐2,2'‐ bithiophene‐5,5'‐ diyl)bis(triMethylstann ane) 5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide Apixaban IMpurity 6 Apixaban IMpurity( 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide 1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester Apixaban IMpurity 3 Apixaban Impurity 12 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide Apixaban-13C-D3 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-[4-(5-methyl-2-oxo-1-piperidinyl)phenyl]-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

  • 1-(4-Nitrophenyl)-2-piperidinone
  • 1-(4-Nitrophenyl)-2-piperidone
  • 1-(4-Nitrophenyl)-2-piperidone &gt
  • 2-Piperidinone, 1-(4-nitrophenyl)-
  • Apixaban Impurity 64
  • 1-(4-Nitrophenyl)piperidin-2-one?(ApixabanImpurity)
  • 1H-Pyrazole,3,5-bis(4-chlorophenyl)-4,11-dihydro-
  • RSYY（Cyclobenzaprine hydrochloride)-4
  • 1-(4-NP)-2-piperidinone
  • Carbamazepine Impurity 13
  • 38560-30-4