Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate

Product Name: Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
CAS No.: 27143-07-3
Chemical Name: Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
Synonyms: Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate;(Z)-ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester;Ethyl(z)-2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Apixaban-2;hydrazono);Ethyl chloro;RSYY（Avanafil)-38;RSYY（Avanafil)-43
CBNumber: CB92500866
Molecular Formula: C11H13ClN2O3
Formula Weight: 256.69
MOL File: 27143-07-3.mol

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Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Property

Melting point:: 94℃
Boiling point:: 349.0±44.0 °C(Predicted)
Density: 1.23
storage temp.: 2-8°C
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Solid
pka: 11.63±0.10(Predicted)
color: Yellow to Dark Yellow
InChI: InChI=1S/C11H13ClN2O3/c1-3-17-11(15)10(12)14-13-8-4-6-9(16-2)7-5-8/h4-7,13H,3H2,1-2H3
InChIKey: ATNPZEGMKLGIFA-UHFFFAOYSA-N
SMILES: C(OCC)(=O)C(Cl)=NNC1=CC=C(OC)C=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: Z346018
Product name: Ethyl2-Chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
Packaging: 50mg
Price: $50
Updated: 2021/12/16

Ark Pharm

Product number: AK-94053
Product name: Ethyl2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
Purity: 97%
Packaging: 10g
Price: $68
Updated: 2021/12/16

AK Scientific

Product number: J96727
Product name: (Z)-Ethyl2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
Packaging: 10g
Price: $95
Updated: 2021/12/16

Matrix Scientific

Product number: 058646
Product name: Ethyl-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate
Purity: >95%
Packaging: 500mg
Price: $126
Updated: 2021/12/16

Matrix Scientific

Product number: 058646
Product name: Ethyl-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate
Purity: >95%
Packaging: 1g
Price: $160
Updated: 2021/12/16

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Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Chemical Properties,Usage,Production

Physical properties

Light yellow to dark yellow solid

Uses

Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester is an ester derivative and can be used as an intermediate in the synthesis of apixaban.

Synthesis

Step-1:Water (600 ml) was added to p-anisidine (100 g) at room temperature and the resulting mixture was cooled to 10°C, followed by the addition of concentrated hydrochloric acid (133.5 g). The resulting mixture was cooled to —5°C to 0°C, followed by portion-wise addition of 40 % aqueous sodium nitrite solution over 45 minutes to 1 hour. The resulting mass was stirred for 1 hour 30 minutes at —5°C to0°C, followed by slow addition of 11 % sulfamic acid solution over 1 hour to 1 hour 30 minutes to produce a reaction mass (first part).Step-2:Sodium acetate (146 g) was added to water (300 ml) at room temperature and then stirred for 10 minutes to 15 minutes, followed by the addition of ethyl 2-chloroacetoacetate (160.4g) and acetone (300 ml) at room temperature to form a reaction mixture. The resulting mixture was cooled to 0°C. The resulting mixture was added to the reaction mass (first part) obtained in step-i at —5°C to 0°C and then stirred for 1 hour at the same temperature. Acetone (200 ml) was added to the resulting mass and stirred for 30 minutes at —5°C to 0°C. The resulting mass was settled for 5 hours at —5°C to 0°Cand then filtered the solid. Methanol (150 ml) was added to the resulting solid at room temperature and then stirred for 2 hours at the same temperature. Ethyl 2-chloro-2-(2-(4-methoxyphenyl) hydrazone)acetate was obtained through further purity.

References

[1] Patent: CN104513239, 2017, B. Location in patent: Paragraph 0197; 0238; 0243; 0244
[2] European Journal of Medicinal Chemistry, 2016, vol. 123, p. 431 - 446
[3] Patent: CN107400131, 2017, A. Location in patent: Paragraph 0026; 0031; 0042-0044
[4] Patent: CN105384739, 2016, A. Location in patent: Paragraph 0391; 0392; 0393
[5] Patent: CN104395312, 2016, B. Location in patent: Paragraph 0396; 0451-0455; 0501; 0502-0506

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Suppliers

China 418 China Hong Kong 1 India 42 United States 10 Global 471

Jinan Jianfeng Chemical Co., Ltd.

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Shijiazhuang Sdyano Fine Chemical Co., Ltd.

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Adamas Reagent, Ltd.

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View Lastest Price from Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 27143-07-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-10-27

Hebei Chuanghai Biotechnology Co., Ltd

Product: Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 27143-07-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-06

Speranza Chemical Co., Ltd.

Product: Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate 27143-07-3
Price: US $20.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20 tons
Release date: 2019-12-24

27143-07-3, Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetateRelated Search:

Apixaban Impurity 20 (4,4'‐didodecyl‐2,2'‐ bithiophene‐5,5'‐ diyl)bis(triMethylstann ane) 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide Apixaban Impurity 13 ETHYL (2E)-CHLORO[(4-CHLOROPHENYL)HYDRAZONO]ACETATE 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid Apixaban IMpurity 3 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide Apixaban Impurity 11 Apixaban IMpurity 5 (BMS-591329-01) 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Nitrophenyl)-2-piperidinone 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-[4-(5-methyl-2-oxo-1-piperidinyl)phenyl]-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl (R)-3-Piperidinamine dihydrochloride

2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]

ethyl 2-chloro-2-[(4-methoxyphenyl)hydrazinylidene]acetate

Apixaban Impurity B

(Z)-Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate (Apixaban)

Apixaban-2

1-(4-methoxyphenyl)-4-(2-((4-(2-oxopiperidin-1-yl)phenyl)amino)ethyl)-1H-pyrazole-3,5-dicarboxamide

Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester

Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate

(Z)- Ethyl chloro[(4-Methoxyphenyl)hydrazono]acetate

Ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate

(Z)-ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate

Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester

2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene], ethyl ester

ethyl chloro[2-(4-Methoxyphenyl)hydrazinylidene]acetate

thyl chloro[2-(4-methoxyphenyl)hydrazinylidene]acetate

Chloro((4-Methoxyphenyl)hydrazone)acetic acid ethyl ester

Ethyl(z)-2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate

1. 2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene]acetic acid ethyl ester

2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene] acetic acid, ethyl ester

Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester

ethyl (2Z)-2-chloro-2-[(4-methoxyphenyl)hydrazinylidene]acetate

Apixaban Intermediate 1

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)

hydrazono)

Acetic acid, chloro[(4-methoxyphenyl)hydrazono]-, ethyl ester

Apixaban intermediates，Ethyl chloro[2-(4- methoxyphenyl)hydrazinylidene]acetate

ethyl 7-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate，Aceticacid,2-chloro-2-[2-(4- methoxyphenyl)hydrazinylidene], ethyl ester

Apixaban ethyl chloroacetate

Apixaban Impurity 158

2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene] Apixaban Impurity 18

Ethyl 2-chloro-2-(2 -(4-methoxyphenyl)hydrazono)acetate chloro ester

Impurity of apixaban382

ethyl 2-chloro-2-[(4-methoxyphenyl)hydrazono]acetate

Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl este

Aceticacid,2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]-,ethylester,(8Z)-

RSYY（Avanafil)-38

RSYY（Avanafil)-43

Ethyl [(4-methoxyphenyl)hydrazono]chloroacetate

Ethyl chloro

(Z)-Ethyl-2-C-2-(2-(4-Methoxy Phenyl) Hydrazone acetate

Ethyl chloro[(4-methoxyphenyl)hydrazono]acetat

Ethyl 2-chloro-2-[2-(4-methyoxyphenyl)hydrazono]acetate

Apixaban Impurity 2

Ethyl[(4-methoxyphenyl)hydrazino]chloroacetate

(4-methoxyphenyl) hydrazino] chloroacetic acid ethyl ester

Ethyl 2-chloro-2-[2-(4-methoxyphenyl)hydrazineylidene]acetate

ETHYL 2-CHLORO-2-(2-(4-METHOXYPHENYL)HYDRAZONO)ACETATE 99%

Apixaban Impurity 27 (Mixture of Z and E Isomers)

Ethyl-2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate (Intermediate of Apixaban)

27143-07-3

27143-07-0

27143-07-2

27143-07-3