ChemicalBook > CAS DataBase List > Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate

Product Name
Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
CAS No.
27143-07-3
Chemical Name
Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
Synonyms
Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate;(Z)-ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester;Ethyl(z)-2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Apixaban-2;hydrazono);Ethyl chloro;RSYY（Avanafil)-38;RSYY（Avanafil)-43
CBNumber
CB92500866
Molecular Formula
C11H13ClN2O3
Formula Weight
256.69
MOL File
27143-07-3.mol
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Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Property

Melting point:
94℃
Boiling point:
349.0±44.0 °C(Predicted)
Density 
1.23
storage temp. 
2-8°C
solubility 
Chloroform (Sparingly), Methanol (Slightly)
form 
Solid
pka
11.63±0.10(Predicted)
color 
Yellow to Dark Yellow
InChI
InChI=1S/C11H13ClN2O3/c1-3-17-11(15)10(12)14-13-8-4-6-9(16-2)7-5-8/h4-7,13H,3H2,1-2H3
InChIKey
ATNPZEGMKLGIFA-UHFFFAOYSA-N
SMILES
C(OCC)(=O)C(Cl)=NNC1=CC=C(OC)C=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
Z346018
Product name
Ethyl2-Chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
Packaging
50mg
Price
$50
Updated
2021/12/16
Ark Pharm
Product number
AK-94053
Product name
Ethyl2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
Purity
97%
Packaging
10g
Price
$68
Updated
2021/12/16
AK Scientific
Product number
J96727
Product name
(Z)-Ethyl2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
Packaging
10g
Price
$95
Updated
2021/12/16
Matrix Scientific
Product number
058646
Product name
Ethyl-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate
Purity
>95%
Packaging
500mg
Price
$126
Updated
2021/12/16
Matrix Scientific
Product number
058646
Product name
Ethyl-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate
Purity
>95%
Packaging
1g
Price
$160
Updated
2021/12/16
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Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Chemical Properties,Usage,Production

Physical properties

Light yellow to dark yellow solid

Uses

Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester is an ester derivative and can be used as an intermediate in the synthesis of apixaban.

Synthesis

Step-1:Water (600 ml) was added to p-anisidine (100 g) at room temperature and the resulting mixture was cooled to 10°C, followed by the addition of concentrated hydrochloric acid (133.5 g). The resulting mixture was cooled to —5°C to 0°C, followed by portion-wise addition of 40 % aqueous sodium nitrite solution over 45 minutes to 1 hour. The resulting mass was stirred for 1 hour 30 minutes at —5°C to0°C, followed by slow addition of 11 % sulfamic acid solution over 1 hour to 1 hour 30 minutes to produce a reaction mass (first part).Step-2:Sodium acetate (146 g) was added to water (300 ml) at room temperature and then stirred for 10 minutes to 15 minutes, followed by the addition of ethyl 2-chloroacetoacetate (160.4g) and acetone (300 ml) at room temperature to form a reaction mixture. The resulting mixture was cooled to 0°C. The resulting mixture was added to the reaction mass (first part) obtained in step-i at —5°C to 0°C and then stirred for 1 hour at the same temperature. Acetone (200 ml) was added to the resulting mass and stirred for 30 minutes at —5°C to 0°C. The resulting mass was settled for 5 hours at —5°C to 0°Cand then filtered the solid. Methanol (150 ml) was added to the resulting solid at room temperature and then stirred for 2 hours at the same temperature. Ethyl 2-chloro-2-(2-(4-methoxyphenyl) hydrazone)acetate was obtained through further purity.

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Suppliers

China 409 China Hong Kong 1 India 42 United States 10 Global 462
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View Lastest Price from Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate manufacturers

Shandong Huizhihan Supply Chain Co., Ltd
Product
Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 27143-07-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
2000
Release date
2024-12-11
Speranza Chemical Co., Ltd.
Product
Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate 27143-07-3
Price
US $20.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20 tons
Release date
2019-12-24
Jinan Million Pharmaceutical Co., Ltd
Product
Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 27143-07-3
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1200KG/M
Release date
2023-08-17

27143-07-3, Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetateRelated Search:

Apixaban Impurity 20 (4,4'‐didodecyl‐2,2'‐ bithiophene‐5,5'‐ diyl)bis(triMethylstann ane) 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide Apixaban Impurity 13 ETHYL (2E)-CHLORO[(4-CHLOROPHENYL)HYDRAZONO]ACETATE 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid Apixaban IMpurity 3 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide Apixaban Impurity 11 Apixaban IMpurity 5 (BMS-591329-01) 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Nitrophenyl)-2-piperidinone 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-[4-(5-methyl-2-oxo-1-piperidinyl)phenyl]-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl (R)-3-Piperidinamine dihydrochloride

  • 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]
  • ethyl 2-chloro-2-[(4-methoxyphenyl)hydrazinylidene]acetate
  • Apixaban Impurity B
  • (Z)-Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate (Apixaban)
  • Apixaban-2
  • 1-(4-methoxyphenyl)-4-(2-((4-(2-oxopiperidin-1-yl)phenyl)amino)ethyl)-1H-pyrazole-3,5-dicarboxamide
  • Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester
  • Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate
  • (Z)- Ethyl chloro[(4-Methoxyphenyl)hydrazono]acetate
  • Ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate
  • (Z)-ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate
  • Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester
  • 2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene], ethyl ester
  • ethyl chloro[2-(4-Methoxyphenyl)hydrazinylidene]acetate
  • thyl chloro[2-(4-methoxyphenyl)hydrazinylidene]acetate
  • Chloro((4-Methoxyphenyl)hydrazone)acetic acid ethyl ester
  • Ethyl(z)-2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate
  • 1. 2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene]acetic acid ethyl ester
  • 2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene] acetic acid, ethyl ester
  • Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester
  • ethyl (2Z)-2-chloro-2-[(4-methoxyphenyl)hydrazinylidene]acetate
  • Apixaban Intermediate 1
  • Ethyl 2-chloro-2-(2-(4-methoxyphenyl)
  • hydrazono)
  • Acetic acid, chloro[(4-methoxyphenyl)hydrazono]-, ethyl ester
  • Apixaban intermediates，Ethyl chloro[2-(4- methoxyphenyl)hydrazinylidene]acetate
  • ethyl 7-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate，Aceticacid,2-chloro-2-[2-(4- methoxyphenyl)hydrazinylidene], ethyl ester
  • Apixaban ethyl chloroacetate
  • Apixaban Impurity 158
  • 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene] Apixaban Impurity 18
  • Ethyl 2-chloro-2-(2 -(4-methoxyphenyl)hydrazono)acetate chloro ester
  • Impurity of apixaban382
  • ethyl 2-chloro-2-[(4-methoxyphenyl)hydrazono]acetate
  • Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl este
  • Aceticacid,2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]-,ethylester,(8Z)-
  • RSYY（Avanafil)-38
  • RSYY（Avanafil)-43
  • Ethyl [(4-methoxyphenyl)hydrazono]chloroacetate
  • Ethyl chloro
  • (Z)-Ethyl-2-C-2-(2-(4-Methoxy Phenyl) Hydrazone acetate
  • Ethyl chloro[(4-methoxyphenyl)hydrazono]acetat
  • Ethyl 2-chloro-2-[2-(4-methyoxyphenyl)hydrazono]acetate
  • Apixaban Impurity 2
  • 27143-07-3
  • 27143-07-0
  • 27143-07-2
  • 27143-07-3