3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

Physical Form

Product Name: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
CAS No.: 881386-01-2
Chemical Name: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Synonyms: Apixaban Impurity 65;Apixaban Impurity 60;RRSYY(Fasoracetam)-4;3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one;3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone;3,3-dichloro-1-(4-nitrophenyl)2-2-piperidinone;2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-;2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-,881386-01-2;3,3-Dichloro-1-(4-Nitrophenyl)piperidin-2-one2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl);3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one
CBNumber: CB92594346
Molecular Formula: C11H10Cl2N2O3
Formula Weight: 289.11
MOL File: 881386-01-2.mol

More

Less

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Property

Boiling point:: 520.2±50.0 °C(Predicted)
Density: 1.50
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: -7.38±0.40(Predicted)
color: Light Yellow to Yellow
InChI: InChI=1S/C11H10Cl2N2O3/c12-11(13)6-1-7-14(10(11)16)8-2-4-9(5-3-8)15(17)18/h2-5H,1,6-7H2
InChIKey: KKVYXBZVPRSWHE-UHFFFAOYSA-N
SMILES: N1(C2=CC=C([N+]([O-])=O)C=C2)CCCC(Cl)(Cl)C1=O

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-M2357
Product name: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Purity: 99.73%
Packaging: 10g
Price: $50
Updated: 2021/12/16

Ambeed

Product number: A985233
Product name: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Purity: 97%
Packaging: 25g
Price: $67
Updated: 2021/12/16

aablocks

Product number: AA00GTWP
Product name: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Purity: 98%
Packaging: 10g
Price: $87
Updated: 2021/12/16

Crysdot

Product number: CD11035802
Product name: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Purity: 97%
Packaging: 5g
Price: $90
Updated: 2021/12/16

aablocks

Product number: AA00GTWP
Product name: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Purity: 98%
Packaging: 25g
Price: $127
Updated: 2021/12/16

More

Less

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Chemical Properties,Usage,Production

Physical Form

Light Yellow to Yellow Solid

Description

3, 3-dichloro-1 -(4-nitrophenyl) -2-piperidinone is an important pharmaceutical intermediate, as it can be used to prepare apixaban derivatives. Apixaban is a small molecular selective FXa inhibitor of pyrazole derivatives. Similar to Rivaroxaban, apixaban has two binding sites to Factor Xa, where 4-methoxyphenyl in the apixaban structure partially binds the S1 pocket of Factor Xa and aryllactam partially binds the S4 pocket of Factor Xa.

Uses

3,??3-??Dichloro-??1-??(4-??nitrophenyl)??piperidin-??2-??one is a reagent used in the preparation of novel tetrahydropyrazolopyridone derivatives. Used in the preparation of anti-coagulants.

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Suppliers

China 127 India 8 United States 3 Global 138

Jinan Billion Pharmaceutical Technology Co., Ltd

Tel: +86-15589952515
Email: 80912934@qq.com
Country: China
ProdList: 57
Advantage: 58

Jilin Lianben Technology Development Co., Ltd

Tel: 0432-62601618 13756693631
Fax: 0432-62601618
Email: wangjiaqi@lianben.com
Country: China
ProdList: 46
Advantage: 58

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Jinan Chenghui Shuangda biological Co., LTD

Tel: 0531-0531-58897003 15550412551
Fax: 0531-58897003
Email: market@jnchsd.com
Country: China
ProdList: 229
Advantage: 62

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Suzhou Carbonwell Pharma-Tech Co., Ltd

Tel: 0512-0512-88981216 13776013740
Email: 1320558046@qq.com
Country: China
ProdList: 72
Advantage: 58

Acesys Pharmatech

Tel: 18860950986
Email: tangmanman@zenjipharma.com
Country: China
ProdList: 1733
Advantage: 55

Shanghai Arbor Chemical Co., Ltd.

Tel: 021-60451683 15021268886
Fax: +86-21-60451682
Email: sales@arborchemical.com
Country: China
ProdList: 896
Advantage: 55

Suzhou lipin Chemical Co., Ltd

Tel: 0512-0512-67509664 19888480046
Country: China
ProdList: 121
Advantage: 58

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-86818997 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2966
Advantage: 60

More

Less

View Lastest Price from 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one manufacturers

Wuhan Biocar Pharmacy CO.,Ltd.

Product: 3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone 881386-01-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 800kg
Release date: 2025-03-18

Speranza Chemical Co., Ltd.

Product: 2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)- 881386-01-2
Price: US $20.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20 tons
Release date: 2019-12-24

Henan Aochuang Chemical Co.,Ltd.

Product: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one 881386-01-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

881386-01-2, 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-oneRelated Search:

Apixaban Impurity 16 (4,4'‐didodecyl‐2,2'‐ bithiophene‐5,5'‐ diyl)bis(triMethylstann ane) Apixaban-13C-D3 Apixaban IMpurity 5 (BMS-591329-01) Apixaban IMpurity(BMS-778960-01) ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate 1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide Apixaban Apixaban IMpurity( Apixaban IMpurity 6 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid Apixaban IMpurity 3 Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester ETHYL (2E)-CHLORO[(4-CHLOROPHENYL)HYDRAZONO]ACETATE 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide

3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone

3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one

3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one

2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-

Apixaban Impurity 60

Apixaban Impurity 65

3,3-dichloro-1-(4-nitrophenyl)2-2-piperidinone

2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-,881386-01-2

RRSYY(Fasoracetam)-4

3,3-Dichloro-1-(4-Nitrophenyl)piperidin-2-one2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)

881386-01-2