Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate

ChemicalBook > CAS DataBase List > Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate

Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate

Product Name: Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate
CAS No.: 473927-63-8
Chemical Name: Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate
Synonyms: Apixaban I;Apixaban int;Apixaban Impurity O;Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]acetate;Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate;Ethyl(2Z)-2-chloro-2-((4-methoxyphenyl)hydrazono)acetate;Acetic acid, chloro[(4-methoxyphenyl)hydrazono]-, ethyl este...;Ethyl (2Z)-2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]acetate;ethyl (2Z)-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate;Acetic acid, chloro[(4-Methoxyphenyl)hydrazono]-, ethyl ester, (2Z)-
CBNumber: CB32514108
Molecular Formula: C11H13ClN2O3
Formula Weight: 256.69
MOL File: 473927-63-8.mol

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Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate Property

Boiling point:: 349.0±44.0 °C(Predicted)
Density: 1.23
vapor pressure: 0.008Pa at 25℃
pka: 11.63±0.10(Predicted)
InChI: InChI=1S/C11H13ClN2O3/c1-3-17-11(15)10(12)14-13-8-4-6-9(16-2)7-5-8/h4-7,13H,3H2,1-2H3/b14-10-
InChIKey: ATNPZEGMKLGIFA-UVTDQMKNSA-N
SMILES: C(OCC)(=O)/C(/Cl)=N/NC1=CC=C(OC)C=C1
LogP: 2.53

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Crysdot

Product number: CD12069983
Product name: (Z)-Ethyl2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
Purity: 95+%
Packaging: 5g
Price: $360
Updated: 2021/12/16

Alichem

Product number: 473927638
Product name: (Z)-Ethyl2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
Packaging: 10g
Price: $523.8
Updated: 2021/12/16

Crysdot

Product number: CD12069983
Product name: (Z)-Ethyl2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
Purity: 95+%
Packaging: 10g
Price: $540
Updated: 2021/12/16

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Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate Chemical Properties,Usage,Production

Uses

Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical and pharmaceutical production processes.

Synthesis

Preparation of ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate To p-anisidine (16 g, 0.129 mol) in conc. HCL (40 mL), 100 mL) H2O, cooled to -5?? C. and sodium nitrite (9.4 g, 0.136 mol) in H2O (60 mL) was added. The reaction mixture was stirred at -5?? C. for 20 min and a mixture of ethylchloroacetoacetate (22 g, 0.133 mol), ethanol (100 mL), sodiumacetate (32 g, 0.389 mmol), and H2O (400 mL) was added. The reaction was allowed to warm up to room temperature and stirred for 2h. The product precipitated as a black solid. It was filtered and dried (30 g). 1H-NMR (CDCl3) |? 8.28 (s, 1H), 7.18 (d, 2H), 6.90 (d, 2H), 4.41 (q, 2H), 3.80 (s, 3H), 1.42 (t, 3H) ppm.

Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate 473927-63-8
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1200KG/M
Release date: 2023-08-15

Speranza Chemical Co., Ltd.

Product: Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate 473927-63-8
Price: US $30.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 300MT/year
Release date: 2019-12-12

Career Henan Chemical Co

Product: Ethyl(2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate 473927-63-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: g/kg/T
Release date: 2019-12-18

473927-63-8, Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoateRelated Search:

Apixaban IMpurity 2 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate ETHYL (2E)-CHLORO[(4-CHLOROPHENYL)HYDRAZONO]ACETATE 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide 1-(4-(2-methyl-6-oxopiperidin-1-yl)phenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one 1-(4-Hydroxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate Apixaban IMpurity(BMS-591329-01) 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Apixaban Impurity 16 Apixaban Impurity 13 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 1-(4-Nitrophenyl)-2-piperidinone Apixaban

Acetic acid, chloro[(4-Methoxyphenyl)hydrazono]-, ethyl ester, (2Z)-

Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate

(2Z)-2-Chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]acetic acid ethyl ester

Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]acetate

Apixaban I

ethyl (2Z)-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate

Apixaban Impurity O

Apixaban int

Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]-, ethyl ester, (2Z)-

Acetic acid, chloro[(4-methoxyphenyl)hydrazono]-, ethyl este...

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetateQ: What is Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Q: What is the CAS Number of Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate

Ethyl (2Z)-2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]acetate

Ethyl(2Z)-2-chloro-2-((4-methoxyphenyl)hydrazono)acetate

473927-63-8