1-BROMO-4-DODECYLBENZENE

1-BROMO-4-DODECYLBENZENE Property

Melting point:

17 °C

Boiling point:

191°C 4mm

Density 

1,07 g/cm³

Flash point:

17 °C

refractive index 

1.5034

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Almost colorless

Safety

Safety Statements 

23-24/25

HS Code 

29039990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

1-BROMO-4-DODECYLBENZENE Chemical Properties,Usage,Production

Chemical Properties

Clear colorless liquid

Synthesis

General procedure for the synthesis of 1-bromo-4-dodecylbenzene from 1-(4-bromophenyl)dodecan-1-one: Hydrazine monohydrate (23.6 mL, 4.5 eq.) and potassium hydroxide (24.3 g, 4 eq.) were added to a solution of 1-(4-bromophenyl)dodecan-1-one (36.5 g, 108.87 mmol) in triethylene glycol (180 mL). The reaction mixture was stirred under reflux conditions for about 15 hours. Upon completion of the reaction, the mixture was cooled to room temperature, poured into water, acidified with concentrated hydrochloric acid to pH < 7, and extracted with dichloromethane (3 x 100 mL). The organic phases were combined, washed with water (2 x 50 mL), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: 100% pentane) to afford 21.2 g (60% yield, not optimized) of the colorless oily target compound 1-bromo-4-dodecylbenzene. The product was analyzed and confirmed to be consistent with literature data.

References

[1] Chemistry - A European Journal, 2001, vol. 7, # 10, p. 2197 - 2205
[2] Chemistry - A European Journal, 2000, vol. 6, # 23, p. 4327 - 4342
[3] Patent: US2008/267892, 2008, A1. Location in patent: Page/Page column 10
[4] Chemistry - A European Journal, 2017, vol. 23, # 72, p. 18129 - 18133
[5] Journal of Organic Chemistry, 2015, vol. 80, # 19, p. 9401 - 9409