MMP-13 Inhibitor

Product Name: MMP-13 Inhibitor
CAS No.: 544678-85-5
Chemical Name: MMP-13 Inhibitor
Synonyms: DB04760;MMP-13 Inhibitor;DB04760 (DB 04760);DB04760 (COMPOUND 4);MMP-13 Inhibitor inhibitor;N,N'-Bis[(4-fluoro-3-methylphenyl)methyl]-4,6-pyrimidinedicarboxamide;4,6-Pyrimidinedicarboxamide, N4,N6-bis[(4-fluoro-3-methylphenyl)methyl]-;N4,N6-Bis(4-fluoro-3-Methylbenzyl)pyriMidine-4,6-dicarboxaMide
CBNumber: CB92602854
Molecular Formula: C22H20F2N4O2
Formula Weight: 410.42
MOL File: 544678-85-5.mol

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MMP-13 Inhibitor Property

Boiling point:: 684.6±55.0 °C(Predicted)
Density: 1.286±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: ≤0.5mg/ml in ethanol;2mg/ml in DMSO;2mg/ml in dimethyl formamide
pka: 11.79±0.46(Predicted)
form: Light yellow crystalline solid.

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Safety

HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19540
Product name: MMP-13 Inhibitor
Purity: ≥98%
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 19540
Product name: MMP-13 Inhibitor
Purity: ≥98%
Packaging: 5mg
Price: $355
Updated: 2024/03/01

Cayman Chemical

Product number: 19540
Product name: MMP-13 Inhibitor
Purity: ≥98%
Packaging: 10mg
Price: $601
Updated: 2024/03/01

ApexBio Technology

Product number: C4331
Product name: MMP-13Inhibitor
Packaging: 10mg
Price: $686
Updated: 2021/12/16

AK Scientific

Product number: Z3393
Product name: Pyrimidine-4,6-dicarboxylicacidbis-(4-fluoro-3-methyl-benzylamide)
Packaging: 10mg
Price: $768
Updated: 2021/12/16

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MMP-13 Inhibitor Chemical Properties,Usage,Production

Description

MMP-13 Inhibitor is a pyrimidine dicarboxamide that inhibits matrix metalloproteinase-13 (MMP-13, also known as collagenase-3) with an IC₅₀ value of 8 nM. MMP-13 Inhibitor binds to pockets that are unique to MMP-13, rather than the catalytic zinc, and thus is specific for MMP-13 over other MMPs. MMP-13 Inhibitor blocks osterix-dependent calcification of matrices in limb bud cells during endochondral ossification.

Chemical Properties

White crystal

in vitro

mmp-13 inhibitor was previously synthesized as a pyrimidine dicarboxamide that could inhibit the matrix metalloproteinase-13 (mmp-13) with the ic50 of 8 nm. moreover, mmp-13 inhibitor was found to be able to bind to mmp pockets that are unique to mmp-13 rather than the catalytic zinc, and therefore was specific for mmp-13 over other mmps. in addition, during endochondral ossification, mmp-13 inhibitor could also block osterix-dependent calcification of matrices in limb bud cells [1, 2, 3].

IC 50

8 nm

References

1. carrascal, n.a. and rizzo, r.c. calculation of binding free energies for non-zinc chelating pyrimidine dicarboxamide inhibitors with mmp-13. bioorg.med.chem.lett. 19(1), (2009).2. engel, c.k.,pirard, b.,schimanski, s., et al. structural basis for the highly selective inhibition of mmp-13. chem.biol. 12(2), 181-189 (2005).3. nishimura, r.,wakabayashi, m.,hata, k., et al. osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (mmp13) expression in association with transcription factor runx2 during endochondral ossification. j.biol.chem. 287(40), 33179-33190 (2012).

MMP-13 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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MMP-13 Inhibitor Suppliers

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MMP-13 Inhibitor

N<sup>4</sup>,N<sup>6</sup>-Bis(4-fluoro-3-Methylbenzyl)pyriMidine-4,6-dicarboxaMide

N,N'-Bis[(4-fluoro-3-methylphenyl)methyl]-4,6-pyrimidinedicarboxamide

DB04760 (COMPOUND 4)

DB04760

DB04760 (DB 04760)

4,6-Pyrimidinedicarboxamide, N4,N6-bis[(4-fluoro-3-methylphenyl)methyl]-

MMP-13 Inhibitor inhibitor

544678-85-5

C22H20F2N4O2