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Voriconazole-d3

Product Name
Voriconazole-d3
CAS No.
188416-29-7
Chemical Name
Voriconazole-d3
Synonyms
3R)-2-(2;VORICONAZOLE-D3;Voriconazole PI-6;(2R,3R)-Voriconazole;Fluconazole Intermediate 2;Voriconazole Intermediate II;Intermediate 2 of voriconazole;4-triazol-1-yl)-2-butanol (RaceMic Voriconazole);4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1;(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
CBNumber
CB92610550
Molecular Formula
C16H14F3N5O
Formula Weight
349.31
MOL File
188416-29-7.mol
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Voriconazole-d3 Property

Boiling point:
508.6±60.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
pka
11.54±0.29(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17803
Product name
Voriconazole-d3
Purity
≥99% deuterated forms (d<sub>1</sub>-d<sub>3</sub>)
Packaging
500 μg
Price
$175
Updated
2023/06/20
Cayman Chemical
Product number
17803
Product name
Voriconazole-d3
Purity
≥99% deuterated forms (d<sub>1</sub>-d<sub>3</sub>)
Packaging
1 mg
Price
$306
Updated
2023/06/20
TRC
Product number
V759995
Product name
(±)-Voriconazole
Packaging
500mg
Price
$375
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0344808
Product name
(2R,3S,2S,3R)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUORO-4-PYRIMIDINYL)-1-(1H-1,2,4-TRIAZOL-1-YL)-2-BUTANOL
Purity
95.00%
Packaging
5MG
Price
$496.38
Updated
2021/12/16
Matrix Scientific
Product number
100266
Product name
(2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
Purity
95+%
Packaging
250mg
Price
$742
Updated
2021/12/16
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Voriconazole-d3 Chemical Properties,Usage,Production

Description

Voriconazole-d3 is an Ergosterol biosynthesis inhibitor and a labeled form of Voriconazole. This mono triazole antifungal agent inhibits the growth of Candida, Cryptococcus, and Aspergillus species. Studies suggest that Voriconazole-d3 can be synthesized by modifying the structure of fluconazole. This antifungal agent functions by inhibiting cytochrome P450 dependent 14-α-sterol demethylase, which is responsible for the biosynthesis of Ergosterol. Furthermore, Voriconazole-d3 inhibits fungal growth, cell wall thinning, and cell membrane degradation.

Uses

Voriconazole is a triazole antifungal agent used primarily in the treatment or prevention of aspergillosis and candidal infections. However, its therapy may cause transient, asymptomatic serum aminotransferase elevations, and it is also a well-known cause of acute drug-induced liver injury.

Application

Voriconazole-d3 is derived from 2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone, which is an antifungal activity, particularly toward Candida albicans and Candida parapsilosis.

References

1. Voriconazole (UK-109,496) inhibits the growth and alters the morphology of fluconazole-susceptible and -resistant Candida species DOI:10.1128/AAC.41.8.1840
Belanger, P., et al. 1997. Antimicrob. Agents Chemother. 41: 1840-1842. PMID: 9257776
2. In vitro activities of voriconazole (UK-109,496) and four other antifungal agents against 394 clinical isolates of Candida spp
Marco, F., et al. 1998. Antimicrob. Agents Chemother. 42: 161-163. PMID: 9449278
3. In vitro activity of the new triazole voriconazole (UK-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens
Espinel-Ingroff, A. 1998. J. Clin. Microbiol. 36: 198-202. PMID: 9431946

Voriconazole-d3 Preparation Products And Raw materials

Raw materials

Preparation Products

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Voriconazole-d3 Suppliers

China 71 United Kingdom 1 United States 2 Global 74
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
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View Lastest Price from Voriconazole-d3 manufacturers

Career Henan Chemical Co
Product
(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole) 188416-29-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

188416-29-7, Voriconazole-d3Related Search:

4-Ethyl-5-fluoropyrimidine Voriconazole Impurity 16 Ethanone, 1-(3,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-Butanesulfonic acid, 4-hydroxy-, methyl ester Pyrimidine, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis[2,6-dichloro-5-fluoro- (9CI) Pyrimidine, 4-bromo-6-(1-bromoethyl)-5-fluoro- 1,2,4-Triazole Voriconazole Impurity 53 Voriconazole (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol ent-Voriconazole FENOFIBRIC ACID ETHYL ESTER (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 4-Ethyl-5-fluoro-6-hydroxypyrimidine 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine 2-Chloro-2',4'-difluoroacetophenone

  • (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole)
  • (2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
  • (2S,3R)-rel-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
  • Voriconazole PI-6
  • (2R,3R)-Voriconazole
  • (R *, S *) 3- (5-fluoropyrimidin-4-yl) -2- (2,4-difluorophenyl) -1- (1H-1,2,4-triazol-1-yl ) -2-butanol
  • (2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
  • 3R)-2-(2
  • 4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1
  • 4-triazol-1-yl)-2-butanol (RaceMic Voriconazole)
  • (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole)ChemicalBook
  • 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-rel-
  • (2R, 3S/2S, 3R)-3-(5-Fluoropyrimidin-4-yl)-2-(2,4-difluorophyenyl)-1-(1H-1,2,4 triazol-1-yl) butan-2-ol {Racemic Voriconazole}
  • VORICONAZOLE-D3
  • Voriconazole Intermediate II
  • Intermediate 2 of voriconazole
  • Fluconazole Intermediate 2
  • (2RS,3SR)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
  • 188416-29-7