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5-Amino-3-(trifluoromethyl)picolinonitrile

Product Name
5-Amino-3-(trifluoromethyl)picolinonitrile
CAS No.
573762-62-6
Chemical Name
5-Amino-3-(trifluoromethyl)picolinonitrile
Synonyms
5-AMino-3-(trifluoroMethyl)pyridine-2-carbonitrile;Apatamide intermediate;Apalutamide Impurity 19;5-Amino-3-(trifluoromethyl)2-cyanopyridine;5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE;5-AMino-3-(trifluroMethyl) picolinonitrile;2-Cyano-3-(Trifluoromethyl)-5-Aminopyridine;5-Amino-2-cyano-3-(trifluoromethyl)pyridine;5-amino-3 - (trifluoromethyl) cyanopyridine;5-Amino-3-(trifluoromethyl)picolinonitrile 97%
CBNumber
CB92611517
Molecular Formula
C7H4F3N3
Formula Weight
187.12
MOL File
573762-62-6.mol
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5-Amino-3-(trifluoromethyl)picolinonitrile Property

Boiling point:
362.2±42.0 °C(Predicted)
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
-1.52±0.10(Predicted)
Appearance
Off-white to yellow Solid
InChI
InChI=1S/C7H4F3N3/c8-7(9,10)5-1-4(12)3-13-6(5)2-11/h1,3H,12H2
InChIKey
WLMSCOVORZUSNW-UHFFFAOYSA-N
SMILES
C1(C#N)=NC=C(N)C=C1C(F)(F)F
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Safety

RIDADR 
3439
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Apolloscientific
Product number
PC53326
Product name
5-Amino-3-(trifluoromethyl)picolinonitrile
Purity
97%
Packaging
1g
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA103833
Product name
5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile
Packaging
100mg
Price
$80
Updated
2021/12/16
SynQuest Laboratories
Product number
3H37-3-76
Product name
5-Amino-3-(trifluoromethyl)picolinonitrile
Purity
97%
Packaging
1g
Price
$128
Updated
2021/12/16
Apolloscientific
Product number
PC53326
Product name
5-Amino-3-(trifluoromethyl)picolinonitrile
Purity
97%
Packaging
5g
Price
$160
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA103833
Product name
5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile
Packaging
250mg
Price
$160
Updated
2021/12/16
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5-Amino-3-(trifluoromethyl)picolinonitrile Chemical Properties,Usage,Production

Uses

5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE is a pyridine heterocyclic organic compound, which can be used as pharmaceutical intermediates.

Synthesis

573762-57-9

573762-62-6

General procedure for the synthesis of 5-amino-3-(trifluoromethyl)cyanopyridine from 2-cyano-5-nitro-3-(trifluoromethyl)pyridine: 2-cyano-3-(trifluoromethyl)-5-nitropyridine A10 (0.095 g, 0.44 mmol) was reacted with powdered iron (0.112 g, 2 mmol) in a mixed solvent of ethyl acetate (1 ml) and acetic acid (1 ml) The reaction was heated for 15 hours in a mixture of ethyl acetate (1ml) and acetic acid (1ml). After completion of the reaction, the solid particles were removed by diatomaceous earth filtration and the filtrate was concentrated. Finally, the target compound A11 (0.075 g, 0.4 mmol, 91% yield) was purified by column chromatography (eluent: EtOAc:pentane=1:1).

References

[1] Patent: JP2016/11315, 2016, A. Location in patent: Paragraph 0040; 0047
[2] Patent: US9388159, 2016, B2. Location in patent: Page/Page column 11; 12; 19
[3] Patent: WO2008/119015, 2008, A2. Location in patent: Page/Page column 47-48
[4] Patent: US2016/152592, 2016, A1. Location in patent: Paragraph 0073; 0080; 0081
[5] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 12, p. 2803 - 2806

5-Amino-3-(trifluoromethyl)picolinonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Amino-3-(trifluoromethyl)picolinonitrile Suppliers

China 265 India 9 United Kingdom 2 United States 7 Global 283
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
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View Lastest Price from 5-Amino-3-(trifluoromethyl)picolinonitrile manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile 573762-62-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2025-09-19
Henan Aochuang Chemical Co.,Ltd.
Product
5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile 573762-62-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Shaanxi Dideu New Materials Co. Ltd
Product
5-Amino-3-(trifluoromethyl)picolinonitrile 573762-62-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-23

573762-62-6, 5-Amino-3-(trifluoromethyl)picolinonitrileRelated Search:

1-Piperazinecarboxylic acid, 4-[3-fluoro-4-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester (2-(4-chlorophenyl)-4,4-diMethylcyclohex-1-enyl)Methanol Apalutamide N/A 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate tert-butyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-bromobenzoate ABT-199 4-(1-CYANOCYCLOBUTYLAMINO)-2-FLUORO-N-METHYLBENZAMIDE 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide 4-Bromo-2-fluoro-N-methylbenzamide

  • 5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE
  • 5-Amino-3-(trifluoromethyl)picolinonitrile 97%
  • 5-AMino-3-(trifluroMethyl) picolinonitrile
  • 5-AMino-3-(trifluoroMethyl)pyridine-2-carbonitrile
  • 5-Amino-3-(trifluoromethyl)2-cyanopyridine
  • 5-Amino-2-cyano-3-(trifluoromethyl)pyridine
  • 5-amino-3-((trifluoromethyl))-pyridin-2-carbonitrile
  • 5-Amino-3-(trifluoromethyl)-2-pyridinecarbonitrile
  • 2-Pyridinecarbonitrile, 5-amino-3-(trifluoromethyl)-
  • 5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile(For export only)
  • 2-Cyano-3-(Trifluoromethyl)-5-Aminopyridine
  • Apalutamide Impurity 19
  • 5-amino-3 - (trifluoromethyl) cyanopyridine
  • Apatamide intermediate
  • 5-Amino-3-(trifluoromethyl) picolinonitrile/ Apalutamide intermediate
  • 5-Amino-3-(trifluoromethyl)pyridinecarbonitrile
  • 5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE 98+
  • 573762-62-6
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