ENMD-2076 (Tartrate)
- Product Name
- ENMD-2076 (Tartrate)
- CAS No.
- 1291074-87-7
- Chemical Name
- ENMD-2076 (Tartrate)
- Synonyms
- ENMD-2076 (Tartrate);ENMD-2076 L-(+)-Tartaric acid;ENMD-2076 tartrate (ENMD 2076;(E)-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine,L-(+)-Tartaric acid
- CBNumber
- CB92624137
- Molecular Formula
- C21H25N7.x(C4H6O6)
- Formula Weight
- 0
- MOL File
- Mol file
ENMD-2076 (Tartrate) Property
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; ≥175.8 mg/mL in DMSO
- form
- solid
N-Bromosuccinimide Price
- Product number
- A4129
- Product name
- ENMD-2076L-(+)-Tartaricacid
- Packaging
- 5mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-0210
- Product name
- ENMD-2076Tartrate
- Purity
- 98.87%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- A4129
- Product name
- ENMD-2076L-(+)-Tartaricacid
- Packaging
- 50mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-0210
- Product name
- ENMD-2076Tartrate
- Purity
- 98.87%
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- orb611816
- Product name
- ENMD-2076 tartrate
- Packaging
- 10mg
- Price
- $210.8
- Updated
- 2021/12/16
ENMD-2076 (Tartrate) Chemical Properties,Usage,Production
Uses
ENMD-2076 (ENMD-981693, ENMD2076) is a antiangiogenic and Aurora kinase inhibitor with IC50 of 3, 13, 350, 23, 40, 93 and 120 nM for Flt-3, AurA, AurB, Src, KDR/VEGFR2 and FGFR1.
Biological Activity
enmd-2076 is an orally bioavailable, small molecule inhibitor of aurora kinases with ic50 values of 14nm and 350nm, respectively against aurora kinase a and aurora kinase b [1].besides aurora kinases, enmd-2076 inhibits multiple kinases involved in various cellular activities. overexpression of aurora kinase a has been found in breast cancers and enmd-2076 is thereby studied in breast cancers. it is reported that enmd-2076 differentially inhibits 29 breast cancer cell lines with ic50 values ranged from 0.25 to 16.1μm. in the clonogenic assays, enmd-2076 totally suppresses the colony formation in the sensitivemda-mb-468 cell line and decreases the formation in thehcc1806, sk-br-3, and bt474 cell lines. enmd-2076 is also reported to cause a g2 cell-cycle arrest at 1.25μm. moreover, enmd-2076 shows antitumor activity in tnbc xenograft models. apart from the breast cancers, enmd-2076 is developed in hematological malignancies therapy. the
References
[1] diamond jr, eckhardt sg, tan ac, newton tp, selby hm, brunkow kl, kachaeva mi, varella-garcia m, pitts tm, bray mr, fletcher gc, tentler jj. predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor enmd-2076 in preclinical breast cancer models. clin cancer res. 2013 jan 1;19(1):291-303.
[2] how j, yee k. enmd-2076 for hematological malignancies. expert opin investig drugs. 2012 may;21(5):717-32.
ENMD-2076 (Tartrate) Preparation Products And Raw materials
Raw materials
Preparation Products
ENMD-2076 (Tartrate) Suppliers
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