Umeclidinium bromide

Product Name: Umeclidinium bromide
CAS No.: 869113-09-7
Chemical Name: Umeclidinium bromide
Synonyms: CS-1562;UMeclidiuM;GSK573719A;Umeclidiniu;umeclidinium;Umecium bromide;Umeclinidium bromide;UMeclidiniuM broMide;Wudi ammonium bromide;Jmechlidinium bromide
CBNumber: CB92625301
Molecular Formula: C29H34BrNO2
Formula Weight: 508.48976
MOL File: 869113-09-7.mol

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Umeclidinium bromide Property

Melting point:: >231°C (dec.)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
InChI: InChI=1S/C29H34NO2.BrH/c31-29(26-12-6-2-7-13-26,27-14-8-3-9-15-27)28-16-19-30(20-17-28,21-18-28)22-23-32-24-25-10-4-1-5-11-25;/h1-15,31H,16-24H2;1H/q+1;/p-1
InChIKey: PEJHHXHHNGORMP-UHFFFAOYSA-M
SMILES: [N+]12(CCOCC3=CC=CC=C3)CCC(C(O)(C3=CC=CC=C3)C3=CC=CC=C3)(CC1)CC2.[Br-]

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H332Harmful if inhaled

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20700
Product name: Umeclidinium (bromide)
Purity: ≥98%
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 20700
Product name: Umeclidinium (bromide)
Purity: ≥98%
Packaging: 50mg
Price: $543
Updated: 2024/03/01

Cayman Chemical

Product number: 20700
Product name: Umeclidinium (bromide)
Purity: ≥98%
Packaging: 100mg
Price: $961
Updated: 2024/03/01

TRC

Product number: U710000
Product name: UmeclidiniumBromide
Packaging: 50mg
Price: $645
Updated: 2021/12/16

ApexBio Technology

Product number: A3900
Product name: Umeclidiniumbromide
Packaging: 10mg
Price: $614
Updated: 2021/12/16

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Umeclidinium bromide Chemical Properties,Usage,Production

Description

Umeclidinium bromide is a long-acting muscarinic acetylcholine antagonist developed by GlaxoSmithKline and approved by the US FDA at the end of 2013 for use in combination with vilanterol, a b2 agonist, for the treatment of chronic obstructive pulmonary disease. Due to umeclidinium’s poor oral bioavailability, the drug is administrated by inhalation as dry powder.

Uses

Umeclidinium Bromide is considered as a potentially long-acting antimuscarinic agent.

Definition

ChEBI: A quaternary ammonium salt that is the bromide salt of umeclidinium. Used in combination with vilanterol for long-term maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease.

Synthesis

Commercially available ethyl isonipecotate (278) was alkylated with 1-bromo-2-chloroethane in the presence of K2CO3 in acetone to give ethyl 1-(2-chloroethyl)piperidine-4-carboxylate (279). This material was then treated with lithium diisopropylamine (LDA) in THF to affect a transannular substitution reaction resulting in the cyclized quinuclidine 280 in 96% yield. Excess of phenyllithium was added to ester 280 in THF starting at low temperature then gradually warming to room temperature to give tertiary alcohol 281 in 61% yield. Amine 281 was finally alkylated with benzyl 2- bromoethyl ether (282) in MeCN/CHCl3 at elevated temperatures to afford umeclidinium bromide (XXXV) in 69% yield.

References

[1] salmon m, luttmann m a, foley j j, et al. pharmacological characterization of gsk573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases. journal of pharmacology and experimental therapeutics, 2013, 345(2): 260-270.

Umeclidinium bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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Umeclidinium bromide Suppliers

China 213 India 5 Israel 1 United Kingdom 2 United States 14 Global 235

Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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BOC Sciences

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Aladdin Scientific

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TargetMol Chemicals Inc.

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ApexBio Technology

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NE Scientific

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Cayman Chemical Company

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United States Biological

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GLAXOSMITHKLINE LLC

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CiVentiChem Inc.

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View Lastest Price from Umeclidinium bromide manufacturers

Sinoway Industrial co., ltd.

Product: Umeclidinium Bromide 869113-09-7
Price: US $0.00-0.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-07-11

Baoji Guokang Healthchem Co., Ltd.

Product: Umeclidinium bromide 869113-09-7
Price: US $124.00/g
Min. Order: 1g
Purity: 99
Supply Ability: 100KG
Release date: 2021-06-04

Hebei Yanxi Chemical Co., Ltd.

Product: Umeclidinium bromide 869113-09-7
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99% HPLC
Supply Ability: 500KG/WEEK
Release date: 2023-09-18

869113-09-7, Umeclidinium bromideRelated Search:

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DIPHENYL-[1-(2-PHENYLMETHOXYETHYL)-1-AZONIABICYCLO[2.2.2]OCTAN-4-YL]METHANOL;BROMIDE

CS-1562

Umeclidinium bromide(GSK573719A)

1-[2-(Benzyloxy)ethyl]-4-(hydroxydiphenylmethyl)-1-quinuclidinium Bromide

Umeclinidium bromide

GSK573719A;GSK-573719A;GSK 573719A

1-(2-(benzyloxy)ethyl)-4-(hydroxydiphenylmethyl)quinuclidin-1-ium bromide

GSK573719A

UMeclidiniuM broMide

UMeclidiuM

UMeclidiniuM BroMide (API)

4-[Hydroxy(diphenyl)methyl]-1-[2-[(phenylmethyl)oxy]ethyl]-1-azoniabicyclo[2.2.2]octane bromide

1-Azoniabicyclo[2.2.2]octane, 4-(hydroxydiphenylMethyl)-1-[2-(phenylMethoxy)ethyl]-, broMide (1:1)

umeclidinium

Umeclidiniu

diphenyl-[1-(2-phenylmethoxyethyl)-1-azoniabicyclo[2.2.2]octan-4-yl]methanol

Umeclidinium bromide, >=98%

Umeclidinium(GSK573719A)

Jmechlidinium bromide

1-Azoniabicyclo[2.2.2]octane

Umeclidinium bromide 1-(2-(benzyloxy)ethyl)-4-(hydroxydiphenylmethyl)quinuclidin-1-ium bromide

High purity CAS 869113-09-7 Umeclidinium bromide in stock

Umecium bromide

Umeclidinium bromide, 10 mM in DMSO

Wudi ammonium bromide

Umeclidinium Bromide : 4-(Hydroxydiphenylmethyl)-1-[2-[(phenylmethyl)oxy]ethyl]-1-azabicyclo[2.2.2]octanium bromide

D10-Umeclidinium Bromide

D7-Umeclidinium Bromide

869113-09-7

C29H34NO2Br

C29H34BrNO2

API

869113-09-7