EMD638683

ChemicalBook > CAS DataBase List > EMD638683

Product Name: EMD638683
CAS No.: 1181770-72-8
Chemical Name: EMD638683
Synonyms: ]-2-ethyL;EMD638683;N'-[2-(3,5-DifL;)-2-hydroxyacetyL;-4-hydroxy-3-methyL;EMD 638683;EMD-638683;EMD638683, 10 mM in DMSO;N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide;2-(3,5-difluorophenyl)-N'-(2-ethyl-4-hydroxy-3-met hylbenzoyl)-2-hydroxyacetohydrazide;Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide
CBNumber: CB92627800
Molecular Formula: C18H18F2N2O4
Formula Weight: 364.34
MOL File: 1181770-72-8.mol

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EMD638683 Property

Boiling point:: 657.6±55.0 °C(Predicted)
Density: 1.363±0.06 g/cm3(Predicted)
storage temp.: -10 to -25°C
solubility: insoluble in H2O; ≥18.2 mg/mL in DMSO; ≥45.8 mg/mL in EtOH with gentle warming
form: solid
pka: 8.68±0.25(Predicted)
color: Off-white to light brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3389
Product name: EMD638683
Packaging: 5mg
Price: $261
Updated: 2021/12/16

ChemScene

Product number: CS-1344
Product name: EMD638683
Purity: 99.74%
Packaging: 5mg
Price: $312
Updated: 2021/12/16

ApexBio Technology

Product number: A3389
Product name: EMD638683
Packaging: 10mg
Price: $336
Updated: 2021/12/16

ChemScene

Product number: CS-1344
Product name: EMD638683
Purity: 99.74%
Packaging: 10mg
Price: $402
Updated: 2021/12/16

ChemScene

Product number: CS-1344
Product name: EMD638683
Purity: 99.74%
Packaging: 50mg
Price: $1086
Updated: 2021/12/16

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EMD638683 Chemical Properties,Usage,Production

Biological Activity

EMD638683 is an orally active and highly selective serum/glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 = 3 μM against HeLa cellular NDRG1 phosphorylation) th at significantly decreased blood pressure in fructose-treated mice but not in control saline-treated or in SGK1-knockout animals (4460 ppm in chow, ~600 mg/kg/day). EMD638683 promotes radiation-induced suicidal death of CaCo-2 colon tumor cells in vitro (50 μM) and decreases the number of colonic tumors following chemical carcinogenesis in vivo (4460 ppm in chow).

target

SGK1

EMD638683 Preparation Products And Raw materials

Raw materials

Preparation Products

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EMD638683 Suppliers

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1181770-72-8, EMD638683Related Search:

4-Hydroxybenzoic acid 4-HYDROXYPHENOXYACETIC ACID Ethylparaben 4'-Hydroxyacetophenone 4-Hydroxyphenylacetic acid

EMD638683

3,5-Difluoro-alpha-hydroxybenzeneacetic acid 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide

EMD 638683;EMD-638683

)-2-hydroxyacetyL

N'-[2-(3,5-DifL

N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide

Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide

]-2-ethyL

-4-hydroxy-3-methyL

2-(3,5-difluorophenyl)-N'-(2-ethyl-4-hydroxy-3-met hylbenzoyl)-2-hydroxyacetohydrazide

EMD638683, 10 mM in DMSO

1181770-72-8