tiraseMtiv (CK-2017357)

Product Name: tiraseMtiv (CK-2017357)
CAS No.: 1005491-05-3
Chemical Name: tiraseMtiv (CK-2017357)
Synonyms: CS-1484;TiraseMtiv;CK 2017357;Tirasemitiv;Tirasemtiv, >=98%;tiraseMtiv (CK-2017357);Tirasemtiv(CK-2017357), >98%;CK-2017357; CK2017357; CK 2017357;inhibit,Tirasemtiv,Inhibitor,CK2017357,CK 2017357;5-ethynyl-3-pentan-3-yl-1H-imidazo[4,5-b]pyrazin-2-one
CBNumber: CB92631164
Molecular Formula: C12H14N4O
Formula Weight: 230.27
MOL File: 1005491-05-3.mol

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tiraseMtiv (CK-2017357) Property

Melting point:: >130°C (dec.)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: Beige to Brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26075
Product name: Tirasemtiv
Purity: ≥98%
Packaging: 5mg
Price: $47
Updated: 2024/03/01

Cayman Chemical

Product number: 26075
Product name: Tirasemtiv
Purity: ≥98%
Packaging: 10mg
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 26075
Product name: Tirasemtiv
Purity: ≥98%
Packaging: 25mg
Price: $182
Updated: 2024/03/01

Cayman Chemical

Product number: 26075
Product name: Tirasemtiv
Purity: ≥98%
Packaging: 50mg
Price: $272
Updated: 2024/03/01

TRC

Product number: T446700
Product name: Tirasemtiv
Packaging: 25mg
Price: $150
Updated: 2021/12/16

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tiraseMtiv (CK-2017357) Chemical Properties,Usage,Production

Description

Tirasemtiv is an activator of the fast skeletal troponin complex. It selectively binds to purified fast skeletal troponin complex (K_d = 40 nM) over slow skeletal (K_d = 3,800 nM) and cardiac troponin complexes. Tirasemtiv (20 μM) slows the rate of calcium release from the fast skeletal troponin complex. It increases the ATPase activity of isolated rabbit fast skeletal myofibrils at a fixed calcium concentration (EC₅₀ = 390 nM) and sensitizes skinned fast skeletal muscle fibers isolated from human and rabbit to calcium in a concentration-dependent manner. Tirasemtiv increases in situ extensor digitorum longus (EDL) muscle force and forelimb grip strength in a rat model of myasthenia gravis. It also increases forelimb grip strength, grid hang test performance, and rotarod performance in a mouse model of amyotrophic lateral sclerosis (ALS) when administered at a dose of 10 mg/kg.

Uses

Tirasemtiv is a fast skeletal muscle troponin activator and is used for treating patients with amyotrophic lateral sclerosis (ALS).

tiraseMtiv (CK-2017357) Preparation Products And Raw materials

Raw materials

Preparation Products

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tiraseMtiv (CK-2017357) Suppliers

China 68 India 3 United States 11 Global 82

Haoyuan Chemexpress Co., Ltd.

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View Lastest Price from tiraseMtiv (CK-2017357) manufacturers

Wuhan Nutra Biotechnology Co.,Ltd

Product: Tirasemtiv;CK-2017357 1005491-05-3
Price: US $500.00-0.00/g
Min. Order: 1g
Purity: 98%+
Supply Ability: 100kgs
Release date: 2021-05-24

Career Henan Chemical Co

Product: tiraseMtiv (CK-2017357) 1005491-05-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 200KG
Release date: 2018-08-19

1005491-05-3, tiraseMtiv (CK-2017357)Related Search:

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1005491-05-3