ChemicalBook > CAS DataBase List > 2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE

2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE

Product Name
2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE
CAS No.
6729-50-6
Chemical Name
2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE
Synonyms
2,3,4,5-tetrahydro-2-benzazepin-1-one;2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE;2,3,4,5-Tetrahydro-1H-2-benzazepin-1-one;2,3,4,5-tetrahydro-1H-2-benzazepine-1-one;1H-2-Benzazepin-1-one, 2,3,4,5-tetrahydro-;2,3,4,5-Tetrahydro-benzo[c]azepin-1-one, CAS 6729-50-6
CBNumber
CB9265923
Molecular Formula
C10H11NO
Formula Weight
161.2
MOL File
6729-50-6.mol
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2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE Property

Melting point:
99-100 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Boiling point:
392.5±12.0 °C(Predicted)
Density 
1.100
storage temp. 
Sealed in dry,Room Temperature
form 
solid
pka
14.78±0.20(Predicted)
Appearance
Off-white to light brown Solid
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Safety

Hazard Codes 
N
Risk Statements 
51/53
Safety Statements 
61
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Hazard statements

H411Toxic to aquatic life with long lasting effects

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS005171
Product name
2,3,4,5-tetrahydro-benzo[c]azepin-1-one
Purity
Aldrich<SUP>CPR</SUP>
Packaging
100 mg
Price
$73.1
Updated
2025/07/31
TRC
Product number
T310033
Product name
2,3,4,5-Tetrahydro-benzo[c]azepin-1-one
Packaging
25mg
Price
$45
Updated
2021/12/16
TRC
Product number
T310033
Product name
2,3,4,5-Tetrahydro-benzo[c]azepin-1-one
Packaging
50mg
Price
$60
Updated
2021/12/16
TRC
Product number
T310033
Product name
2,3,4,5-Tetrahydro-benzo[c]azepin-1-one
Packaging
250mg
Price
$130
Updated
2021/12/16
Apolloscientific
Product number
OR963516
Product name
2,3,4,5-Tetrahydro-benzo[c]azepin-1-one
Purity
97%
Packaging
1g
Price
$125
Updated
2021/12/16
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2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE Chemical Properties,Usage,Production

Chemical Properties

White to beige crystalline powder

Synthesis

529-34-0

6729-50-6

General procedure for the synthesis of 2,3,4,5-tetrahydro-1H-2-benzazepin-1-one from 1-tetrahydronaphthalenone: 2.72 g (41.8 mmol) of sodium azide was added batchwise to a solution of concentrated hydrochloric acid (75 mL) containing 6.11 g (41.8 mmol) of 3,4-dihydronaphthalen-1(2H)-one and the reaction was carried out at 0 °C. Subsequently, the reaction was eluted with hydrochloric acid (75 mL) at 0 °C for 1 h. Stirring was continued at 0 °C for 30 min, then slowly warmed to room temperature and the reaction lasted for 16 hours. Upon completion of the reaction, the reaction mixture was poured into ice water and the pH was adjusted with potassium carbonate to 9. The aqueous phase was extracted with dichloromethane (DCM), the organic phases were combined and dried with anhydrous magnesium sulfate (MgSO?), filtered and concentrated under reduced pressure. The residue was purified by recrystallization from hexane. Further purification by column chromatography (silica gel, eluent hexane/ethyl acetate = 1:2) afforded 1.8 g (11.1 mmol, 27% yield) of the target product 2,3,4,5-tetrahydro-1H-2-benzazepin-1-one.

References

[1] Angewandte Chemie - International Edition, 2018, vol. 57, # 38, p. 12347 - 12351
[2] Angew. Chem., 2018, vol. 130, # 38, p. 12527 - 12531,5
[3] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 11, p. 914 - 919
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 13, p. 5287 - 5307
[5] Angewandte Chemie - International Edition, 2017, vol. 56, # 13, p. 3655 - 3659

2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE Suppliers

China 62 Germany 2 India 1 Switzerland 1 United Kingdom 2 United States 12 Global 80
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
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63687
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United States Biological
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United States
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Synthonix Inc
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United States
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6872
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Riedel-de Haen AG
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Oakwood Products, Inc.
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Country
United States
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AstaTech, Inc
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Combi-Blocks Inc.
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Matrix Scientific
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3B Scientific Corporation
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Country
United States
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6718
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AfferChem, Inc.
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Chem-Impex International, Inc.
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J & W PharmLab, LLC
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United States
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View Lastest Price from 2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE manufacturers

Hebei Runbin Biotechnology Co. LTD
Product
2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE 6729-50-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99.9%
Supply Ability
20tons
Release date
2020-09-11
Career Henan Chemical Co
Product
2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE 6729-50-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-07-09

6729-50-6, 2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONERelated Search:

1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 8-METHOXY-2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE 3-AMINO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE 7-METHOXY-2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE 7-METHOXY-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 7-BROMO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 8-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 7,9-DIMETHYL-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 7-AMINO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 8-METHOXY-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 7-NITRO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 7-BROMO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 8-AMINO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 9-BROMO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE

  • 2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE
  • 2,3,4,5-Tetrahydro-1H-2-benzazepin-1-one
  • 2,3,4,5-tetrahydro-1H-2-benzazepine-1-one
  • 1H-2-Benzazepin-1-one, 2,3,4,5-tetrahydro-
  • 2,3,4,5-tetrahydro-2-benzazepin-1-one
  • 2,3,4,5-Tetrahydro-benzo[c]azepin-1-one, CAS 6729-50-6
  • 6729-50-6