Benzyl (4-broMo-3-fluorophenyl)carbaMate

Product Name: Benzyl (4-broMo-3-fluorophenyl)carbaMate
CAS No.: 510729-01-8
Chemical Name: Benzyl (4-broMo-3-fluorophenyl)carbaMate
Synonyms: Torezolid-16;Tedizolid Impurity 42;Tedizolid impurity583;Torezolid Intermediate4;Terazolamide impurity 17;N-Cbz 4-BroMo-3-fluoroaniline;4-Bromo-3-fluoroaniline, N-CBZ protected;Benzyl (4-broMo-3-fluorophenyl)carbaMate;N-Benzyloxycarbonyl-4-Bromo-3-Fluoroaniline;Phenylmethyl N-(4-bromo-3-fluorophenyl)carbamate
CBNumber: CB92661815
Molecular Formula: C14H11BrFNO2
Formula Weight: 324.14
MOL File: 510729-01-8.mol

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Benzyl (4-broMo-3-fluorophenyl)carbaMate Property

Melting point:: 102-105oC
Boiling point:: 359.7±42.0 °C(Predicted)
Density: 1.543±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Methanol (Slightly)
pka: 12.14±0.70(Predicted)
form: Solid
color: White to Off-White
InChI: InChI=1S/C14H11BrFNO2/c15-12-7-6-11(8-13(12)16)17-14(18)19-9-10-4-2-1-3-5-10/h1-8H,9H2,(H,17,18)
InChIKey: UPTMRBYILBFUPA-UHFFFAOYSA-N
SMILES: C(OCC1=CC=CC=C1)(=O)NC1=CC=C(Br)C(F)=C1

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B683310
Product name: (4-Bromo-3-fluorophenyl)carbamicAcidBenzylEster
Packaging: 5g
Price: $670
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4756-B-02
Product name: 4-Bromo-3-fluoroaniline, N-Cbz protected
Purity: 97%
Packaging: 1g
Price: $88
Updated: 2021/12/16

AK Scientific

Product number: 9839BB
Product name: Benzyl(4-bromo-3-fluorophenyl)carbamate
Packaging: 10g
Price: $230
Updated: 2021/12/16

Ambeed

Product number: A145669
Product name: Benzyl(4-bromo-3-fluorophenyl)carbamate
Purity: 97%
Packaging: 100mg
Price: $7
Updated: 2021/12/16

Ambeed

Product number: A145669
Product name: Benzyl(4-bromo-3-fluorophenyl)carbamate
Purity: 97%
Packaging: 250mg
Price: $10
Updated: 2021/12/16

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Benzyl (4-broMo-3-fluorophenyl)carbaMate Chemical Properties,Usage,Production

Uses

(4-Bromo-3-fluorophenyl)carbamic Acid Benzyl Ester is an intermediate in the synthesis of Tedizolid (T013750), an known oral and intravenous antibiotic.

Synthesis

656-65-5

501-53-1

510729-01-8

General procedure: To a stirred solution of 4-bromo-3-fluoroaniline (50.0 g, 0.263 mol, 1 eq.) in acetone (660 ml) was added sodium bicarbonate (27.63 g, 0.329 mol, 1.25 eq.) and saturated sodium bicarbonate solution (333 ml). The reaction mixture was cooled to 15 °C and benzyl chloroformate (39 ml, 0.276 mol, 1.05 eq.) was added slowly and the reaction temperature was controlled not to exceed 22 °C. After addition, the reaction was stirred at room temperature for 90 minutes. After completion of the reaction, acetone was removed by distillation under reduced pressure. The aqueous phase was extracted with ethyl acetate (3 x 150 ml), the organic phases were combined, washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. After filtration, the organic phase was concentrated under reduced pressure, n-hexane was added and stirred at room temperature for 30 min, and the first solid products were collected by filtration. The filtrate was concentrated, and the residual solid was mixed with heptane and stirred at 0 °C for 30 min, and filtered to obtain the second batch of solid product. The two batches of solids were combined to afford the target compound N-(4-bromo-3-fluorophenyl)formic acid phenylmethyl ester (85.3 g, quantitative yield).

References

[1] Patent: US9133213, 2015, B2. Location in patent: Page/Page column 28
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 23, p. 5310 - 5321
[3] Patent: WO2015/66413, 2015, A1. Location in patent: Page/Page column 141; 142
[4] Patent: WO2010/42887, 2010, A2. Location in patent: Page/Page column 16-17
[5] Patent: EP2692727, 2014, A2. Location in patent: Paragraph 0158-0159

Benzyl (4-broMo-3-fluorophenyl)carbaMate Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzyl (4-broMo-3-fluorophenyl)carbaMate Suppliers

China 154 India 1 United Kingdom 2 United States 7 Global 164

Yancheng ZhengChi biological and Technology Co, Ltd.

Tel: 0515-88230089 18014968800
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Jinan XuanDe Chemical Co., Ltd.

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Adamas Reagent, Ltd.

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BOC Sciences

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T&W GROUP

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TargetMol Chemicals Inc.

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Tianjin Chempharmatech Co.,Ltd.

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Amatek Scientific Co. Ltd.

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View Lastest Price from Benzyl (4-broMo-3-fluorophenyl)carbaMate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Benzyl (4-broMo-3-fluorophenyl)carbaMate 510729-01-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-05-15

Henan Aochuang Chemical Co.,Ltd.

Product: Benzyl (4-broMo-3-fluorophenyl)carbaMate 510729-01-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Anhui Ruihan Technology Co., Ltd

Product: Benzyl (4-broMo-3-fluorophenyl)carbaMate 510729-01-8
Price: US $80.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000tons
Release date: 2023-09-11

510729-01-8, Benzyl (4-broMo-3-fluorophenyl)carbaMateRelated Search:

(R)-3-(4-(6-(1H-tetrazol-5-yl)pyridin-3-yl)-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one (R)-5-(2-fluoro-4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl) phenyl)-2-(2-methyl-2H-tetrazol-5-yl)pyridine 1-oxide Sitagliptin phosphate monohydrate Tedizolid Phosphate (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE (R)-5-(chloromethyl)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)oxazolidin-2-one 2,3-Dichloro-5,6-diphenylpyrazine Olprinone Impurity A Tedizolid Impurity 36 (4-BENZYLOXYCARBONYLAMINOPHENYL)BORONIC ACID, PINACOL ESTER 5-BROMO-2-(2-METHYL-2H-TETRAZOL-5-YL)-PYRIDINE 5-Bromo-2-pyridinecarbonitrile (R)-Glycidyl butyrate (R)-(3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl) phenyl)-2-oxooxazolidin-5-yl)methyl butyrate (S)-(+)-Glycidyl butyrate Torezolid Tedizolid Impurity 34 bis(((R)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl) hydrogen phosphate

Benzyl (4-broMo-3-fluorophenyl)carbaMate

4-Bromo-3-fluoroaniline, N-CBZ protected

Tedizolid Impurity 4: N-benzyloxycarbonyl-4-bromo-3-fluoroaniline

Torezolid-16

Benzyl (4-bromo-3-fluorophenyl)carbamate, Phenylmethyl (4-bromo-3-fluorophenyl)carbamate

N-Cbz 4-BroMo-3-fluoroaniline

(4-Bromo-3-fluorophenyl)carbamic acid benzyl ester

Torezolid Intermediate4

N-(4-BROMO-3-FLUOROPHENYL)CARBAMIC ACID PHENYLMETHYL ESTER

Tedizolid Impurity 42

Carbamic acid, N-(4-bromo-3-fluorophenyl)-, phenylmethyl ester

Tedizolid impurity583

Phenylmethyl N-(4-bromo-3-fluorophenyl)carbamate

Terazolamide impurity 17

N-Benzyloxycarbonyl-4-Bromo-3-Fluoroaniline

510729-01-8

Tedizolid intermediates