ChemicalBook > CAS DataBase List > Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-

Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-

Product Name: Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-
CAS No.: 176957-55-4
Chemical Name: Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-
Synonyms: CS-1839;CCTOO7093;CCT007093;CCT007093[C9369];CCT007093 ，S7485;CCT007093, 10 mM in DMSO;CCT-007093; CCT 007093; CCT007093;2,5-Bis(2-thienylmethylene)-cyclopentanone;(2E,5E)-2,5-Bis(2-thienylmethylene)cyclopentanone;2,5-bis(2-thienylMethylene)-, (E,E)-Cyclopentanone
CBNumber: CB92682247
Molecular Formula: C15H12OS2
Formula Weight: 272.39
MOL File: 176957-55-4.mol

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Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- Property

Melting point:: 222-223℃
storage temp.: 2-8°C
solubility: DMSO: >3mg/mL
form: powder, yellow
color: Light yellow to green yellow
Sensitive: Light Sensitive

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C9369
Product name: CCT007093
Purity: ≥98% (HPLC), powder, yellow
Packaging: 5mg
Price: $85.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: C9369
Product name: CCT007093
Purity: ≥98% (HPLC), powder, yellow
Packaging: 25mg
Price: $326
Updated: 2025/07/31

Cayman Chemical

Product number: 19992
Product name: CCT007093
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19992
Product name: CCT007093
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 19992
Product name: CCT007093
Purity: ≥98%
Packaging: 10mg
Price: $122
Updated: 2024/03/01

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Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- Chemical Properties,Usage,Production

Uses

Acts as a PPM1D inhibitor

Biological Activity

cct007093 is a small-molecule chemical inhibitor of ppm1d with ic50 value of 8.4μm [1].cct007093 is a thienylidene cyclopentanone and shows a potent inhibition of ppm1d in the in vitro assay when using the recombinant phospho-p38 as a substrate. in cellular assay, cct007093 shows specificity for mcf-7 cells over hela cells. it reduces 40% viability of the cells after 2 days. it is found that the cell death induced by cct007093 is dependent on p38 kinase activity. cct007093 mimics the effect of ppm1d rnai in activating p38 kinase. it induces p38 phosphorylation at 4 h post-exposure in mcf-7 cells and the loss of viability can be rescued by sb203580, the specific p38 inhibitor [1].

in vivo

CCT007093 (6.4 mg/kg) enhances liver regeneration and increases the survival rate of mice following major hepatectomy^[1].

Animal Model:	Wild-type mice^[1].
Dosage:	3.2 and 6.4 mg/kg.
Administration:	Injected intraperitoneally 4 times (mice were sacrificed at 36 h post-PH).
Result:	Significantly improved survival in mice following major hepatectomy (80% hepatectomy). The level of PCNA was also significantly increased in the liver of CCT007093-treated mice at 36h, 48h and 72h post-PH.

target

WIP1

References

[1] rayter s, elliott r, travers j, rowlands mg, richardson tb, boxall k, jones k, linardopoulos s, workman p, aherne w, lord cj, ashworth a. a chemical inhibitor of ppm1d that selectively kills cells overexpressing ppm1d. oncogene. 2008 feb 14;27(8):1036-44.

Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- manufacturers

Career Henan Chemical Co

Product: Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- 176957-55-4
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-13

176957-55-4, Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-Related Search:

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CCT007093[C9369]

CCT007093 ，S7485

176957-55-4

Inhibitors