ChemicalBook > CAS DataBase List > Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-
Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-
- Product Name
- Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-
- CAS No.
- 176957-55-4
- Chemical Name
- Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-
- Synonyms
- CS-1839;CCTOO7093;CCT007093;CCT-007093; CCT 007093; CCT007093;2,5-Bis(2-thienylmethylene)-cyclopentanone;(2E,5E)-2,5-Bis(2-thienylmethylene)cyclopentanone;2,5-bis(2-thienylMethylene)-, (E,E)-Cyclopentanone;Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-;(2E,5E)-2,5-Bis(thiophen-2-ylmethylene)cyclopentanone;Cyclopentanone, 2,5-bis(2-thienylmethylene)-, (2E,5E)-
- CBNumber
- CB92682247
- Molecular Formula
- C15H12OS2
- Formula Weight
- 272.39
- MOL File
- 176957-55-4.mol
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Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- Property
- Melting point:
- 222-223℃
- storage temp.
- 2-8°C
- solubility
- DMSO: >3mg/mL
- form
- powder, yellow
- Sensitive
- Light Sensitive
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- C9369
- Product name
- CCT007093
- Purity
- ≥98% (HPLC), powder, yellow
- Packaging
- 5mg
- Price
- $103
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- C9369
- Product name
- CCT007093
- Purity
- ≥98% (HPLC), powder, yellow
- Packaging
- 25mg
- Price
- $393
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- J64165
- Product name
- PPM1D Phosphatase Inhibitor
- Packaging
- 50mg
- Price
- $399
- Updated
- 2021/12/16
Alfa Aesar
- Product number
- J64165
- Product name
- PPM1D Phosphatase Inhibitor
- Packaging
- 10mg
- Price
- $104
- Updated
- 2021/12/16
Cayman Chemical
- Product number
- 19992
- Product name
- CCT007093
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
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Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- Chemical Properties,Usage,Production
Uses
Acts as a PPM1D inhibitor
Biological Activity
cct007093 is a small-molecule chemical inhibitor of ppm1d with ic50 value of 8.4μm [1].cct007093 is a thienylidene cyclopentanone and shows a potent inhibition of ppm1d in the in vitro assay when using the recombinant phospho-p38 as a substrate. in cellular assay, cct007093 shows specificity for mcf-7 cells over hela cells. it reduces 40% viability of the cells after 2 days. it is found that the cell death induced by cct007093 is dependent on p38 kinase activity. cct007093 mimics the effect of ppm1d rnai in activating p38 kinase. it induces p38 phosphorylation at 4 h post-exposure in mcf-7 cells and the loss of viability can be rescued by sb203580, the specific p38 inhibitor [1].
target
WIP1
References
[1] rayter s, elliott r, travers j, rowlands mg, richardson tb, boxall k, jones k, linardopoulos s, workman p, aherne w, lord cj, ashworth a. a chemical inhibitor of ppm1d that selectively kills cells overexpressing ppm1d. oncogene. 2008 feb 14;27(8):1036-44.
Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- manufacturers
Career Henan Chemical Co
- Product
- Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- 176957-55-4
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-13