tert-butyl 3-hydroxyazepane-1-carboxylate

Product Name: tert-butyl 3-hydroxyazepane-1-carboxylate
CAS No.: 478841-10-0
Chemical Name: tert-butyl 3-hydroxyazepane-1-carboxylate
Synonyms: 1-Boc-3-Hydroxy-Azepane;tert-butyl 3-hydroxyazepane-1-carboxylate - [B86805];1H-Azepine-1-carboxylic acid, hexahydro-3-hydroxy-, 1,1-dimethylethyl ester
CBNumber: CB92684195
Molecular Formula: C11H21NO3
Formula Weight: 215.29
MOL File: 478841-10-0.mol

More

Less

tert-butyl 3-hydroxyazepane-1-carboxylate Property

Boiling point:: 310.6±35.0 °C(Predicted)
Density: 1.079±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 14.74±0.20(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-7-5-4-6-9(13)8-12/h9,13H,4-8H2,1-3H3
InChIKey: YLXNIRRSRXUTCK-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCCCC(O)C1

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B704213
Product name: tert-butyl3-hydroxyazepane-1-carboxylate
Packaging: 100mg
Price: $175
Updated: 2021/12/16

AK Scientific

Product number: 5202AQ
Product name: tert-butyl3-hydroxyazepane-1-carboxylate
Packaging: 250mg
Price: $273.2
Updated: 2021/12/16

ChemScene

Product number: CS-0039169
Product name: tert-Butyl3-hydroxyazepane-1-carboxylate
Packaging: 1g
Price: $413
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0385648
Product name: 1-BOC-3-HYDROXY-AZEPANE
Purity: 95.00%
Packaging: 5MG
Price: $505.08
Updated: 2021/12/16

Alichem

Product number: 478841100
Product name: tert-Butyl3-hydroxyazepane-1-carboxylate
Packaging: 1g
Price: $590.42
Updated: 2021/12/16

More

Less

tert-butyl 3-hydroxyazepane-1-carboxylate Chemical Properties,Usage,Production

Synthesis

870842-23-2

478841-10-0

General procedure for the synthesis of tert-butyl 3-hydroxyazepane-1-carboxylate from N-Boc-3-azepanone: Sodium borohydride (NaBH4) (0.98 g, 25.8 mmol) was added batchwise to a solution of N-Boc-3-azepanone (5.5 g, 25.8 mmol) in methanol (55 mL) at 0 °C, and the progress of the reaction was monitored by thin-layer chromatography (TLC). Upon completion of the reaction, the pH of the reaction mixture was adjusted to 5 to 6 with hydrochloric acid (HCl) solution, followed by filtration and extraction with dichloromethane (DCM, 100 mL x 3). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford tert-butyl 3-hydroxyazepane-1-carboxylate (oil, 4.8 g, 87% yield). The structure of the product was confirmed by 1H NMR (400 MHz, d6-DMSO): δppm 3.95-3.93 (m, 1H), 3.71-3.62 (m, 2H), 3.40 (m, 1H), 3.32-3.28 (m, 1H), 3.03 (m, 1H), 1.88-1.65 (m, 4H), 1.55-1.36 ( m, 11H).

References

[1] Patent: US2017/313683, 2017, A1. Location in patent: Paragraph 1046-1047
[2] Patent: WO2012/80990, 2012, A1. Location in patent: Page/Page column 129-130
[3] Patent: US2012/190678, 2012, A1. Location in patent: Page/Page column 80
[4] Process Biochemistry, 2017, vol. 56, p. 90 - 97
[5] Patent: WO2018/26371, 2018, A1. Location in patent: Paragraph 0174

tert-butyl 3-hydroxyazepane-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

tert-butyl 3-hydroxyazepane-1-carboxylate Suppliers

China 35 Global 35

Shanghai Aizikang Pharmaceutical Research Co., Ltd

Tel: 18721109360
Email: 306685371@qq.com
Country: China
ProdList: 1944
Advantage: 58

BePharm Ltd

Tel: 400-685-9117
Fax: 021-51816740
Email: market@bepharm.com
Country: China
ProdList: 15081
Advantage: 60

BioPharmaMatrix,Inc.

Tel: 0510-86010668
Fax: 0510-86010668
Email: sales@biopharmamatrix.com
Country: China
ProdList: 4739
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Pingguo Pharmaceutical Co., Ltd.

Tel: 021-20432229
Fax: QQ2412110556
Email: 2412110556@qq.com
Country: China
ProdList: 6017
Advantage: 55

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

Shanghai Benso Pharmaceutical Technology Co., Ltd.

Tel: 15088289376
Email: 248775804@qq.com
Country: China
ProdList: 4995
Advantage: 58

Shanghai Songfan Pharmaceutical Technology Co., Ltd.

Tel: 17321241880
Email: 485229790@qq.com
Country: China
ProdList: 1750
Advantage: 58

Ningbo Benkang jishi Pharmaceutical Technology Co., Ltd.

Tel: 15990591583
Fax: qq: 1050376806 mailbox : sales@nbpharmabridge.com
Country: China
ProdList: 6109
Advantage: 58

Jiangsu yize medical technology co. LTD

Tel: 18012778619
Email: 3394205705@qq.com
Country: China
ProdList: 9839
Advantage: 58

More

Less

View Lastest Price from tert-butyl 3-hydroxyazepane-1-carboxylate manufacturers

Career Henan Chemica Co

Product: tert-butyl 3-hydroxyazepane-1-carboxylate 478841-10-0
Price: US $8.00/KG
Min. Order: 1g
Purity: Min98% HPLC/GC
Supply Ability: g/kg/ton
Release date: 2020-10-28

Henan Fengda Chemical Co., Ltd

Product: tert-butyl 3-hydroxyazepane-1-carboxylate 478841-10-0
Price: US $32.00-1.50/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-22

478841-10-0, tert-butyl 3-hydroxyazepane-1-carboxylateRelated Search:

tert-butyl (4-bromobutyl)carbamate tert-Butyl 3-oxo-6-chloro-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate Carbamic acid, [(3R,4S)-4-hydroxy-3-pyrrolidinyl]-, 1,1-dimethylethyl ester, rel- (3R,5S)-3,5-DiMethylMorpholine hydrochloride 2-Boc-5-hydroxy-2-azaspiro[3.3]heptane cis-2-(tert-Butoxycarbonylamino)-1-cyclopentanecarboxylic acid cis-2,6-Dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester HEXAHYDRO-PYRROLO[3,4-B]PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-N-Boc-3-hydroxyazetidine 1-Boc-3-hydroxypiperidine 1-(tert-Butoxycarbonyl)-3-pyrrolidinol

1-Boc-3-Hydroxy-Azepane

1H-Azepine-1-carboxylic acid, hexahydro-3-hydroxy-, 1,1-dimethylethyl ester

tert-butyl 3-hydroxyazepane-1-carboxylate - [B86805]

478841-10-0