4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline

Product Name: 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
CAS No.: 959795-70-1
Chemical Name: 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
Synonyms: Naquotinib intermediate;1,3-Propanediol,1-(7-piperidinyl)-;4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline;4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]benzenamine;Benzenamine, 4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]-;4-[4-(4-Methyl-piperazin-1-yl)-piperidin-1-yl]-phenylamine
CBNumber: CB92693292
Molecular Formula: C16H26N4
Formula Weight: 274.4
MOL File: 959795-70-1.mol

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4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline Property

Boiling point:: 447.2±45.0 °C(Predicted)
Density: 1.114±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 8.14±0.42(Predicted)
Appearance: Off-white to gray Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M330485
Product name: 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
Packaging: 1g
Price: $210
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0389600
Product name: 4-(4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL)ANILINE
Purity: 95.00%
Packaging: 5MG
Price: $502.93
Updated: 2021/12/16

Matrix Scientific

Product number: 096682
Product name: 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

AK Scientific

Product number: 6715AC
Product name: 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
Packaging: 25g
Price: $1605
Updated: 2021/12/16

Matrix Scientific

Product number: 096682
Product name: 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
Purity: 95+%
Packaging: 1g
Price: $1647
Updated: 2021/12/16

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4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline Chemical Properties,Usage,Production

Uses

4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline acts as a reagent in the preparation of Gilteritinib derivatives as inhibitors of FLT3-Axl.

Synthesis

959795-69-8

959795-70-1

GENERAL METHOD: 1-methyl-4-(1-(4-nitrophenyl)piperidin-4-yl)piperazine (2.18 g, 6.52 mmol) was dissolved in ethanol (50 mL) and 10% palladium carbon (wet basis, 53% water; 600 mg) was added. The reaction mixture was stirred at room temperature and 1 atm hydrogen atmosphere for 8 hours. Upon completion of the reaction, the insoluble material was removed by Celite filtration and the filtrate was concentrated under vacuum to afford 4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline (1.96 g, 99%) as a light purple solid.

References

[1] Chemical and Pharmaceutical Bulletin, 2018, vol. 66, # 3, p. 251 - 262
[2] Patent: US2009/318441, 2009, A1. Location in patent: Page/Page column 45
[3] European Journal of Medicinal Chemistry, 2019, p. 690 - 709

4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline Suppliers

China 53 India 2 United States 4 Global 59

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Aikon International Limited

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View Lastest Price from 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline manufacturers

Career Henan Chemical Co

Product: 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline 959795-70-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-08-04

959795-70-1, 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)anilineRelated Search:

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4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline

Naquotinib intermediate

4-[4-(4-Methyl-piperazin-1-yl)-piperidin-1-yl]-phenylamine

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959795-70-1