4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
- Product Name
- 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
- CAS No.
- 959795-70-1
- Chemical Name
- 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
- Synonyms
- Naquotinib intermediate;1,3-Propanediol,1-(7-piperidinyl)-;4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline;4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]benzenamine;Benzenamine, 4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]-;4-[4-(4-Methyl-piperazin-1-yl)-piperidin-1-yl]-phenylamine
- CBNumber
- CB92693292
- Molecular Formula
- C16H26N4
- Formula Weight
- 274.4
- MOL File
- 959795-70-1.mol
4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline Property
- Boiling point:
- 447.2±45.0 °C(Predicted)
- Density
- 1.114±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 8.14±0.42(Predicted)
- Appearance
- Off-white to gray Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M330485
- Product name
- 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
- Packaging
- 1g
- Price
- $210
- Updated
- 2021/12/16
- Product number
- CHM0389600
- Product name
- 4-(4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL)ANILINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.93
- Updated
- 2021/12/16
- Product number
- 096682
- Product name
- 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $742
- Updated
- 2021/12/16
- Product number
- 6715AC
- Product name
- 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
- Packaging
- 25g
- Price
- $1605
- Updated
- 2021/12/16
- Product number
- 096682
- Product name
- 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1647
- Updated
- 2021/12/16
4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline Chemical Properties,Usage,Production
Uses
4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline acts as a reagent in the preparation of Gilteritinib derivatives as inhibitors of FLT3-Axl.
Synthesis
959795-69-8
959795-70-1
GENERAL METHOD: 1-methyl-4-(1-(4-nitrophenyl)piperidin-4-yl)piperazine (2.18 g, 6.52 mmol) was dissolved in ethanol (50 mL) and 10% palladium carbon (wet basis, 53% water; 600 mg) was added. The reaction mixture was stirred at room temperature and 1 atm hydrogen atmosphere for 8 hours. Upon completion of the reaction, the insoluble material was removed by Celite filtration and the filtrate was concentrated under vacuum to afford 4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline (1.96 g, 99%) as a light purple solid.
References
[1] Chemical and Pharmaceutical Bulletin, 2018, vol. 66, # 3, p. 251 - 262
[2] Patent: US2009/318441, 2009, A1. Location in patent: Page/Page column 45
[3] European Journal of Medicinal Chemistry, 2019, p. 690 - 709
4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline Suppliers
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View Lastest Price from 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline manufacturers
- Product
- 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline 959795-70-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-08-04