Rubitecan
Description Reference- Product Name
- Rubitecan
- CAS No.
- 91421-42-0
- Chemical Name
- Rubitecan
- Synonyms
- 9-NC;RFS 2000;Oratheci;orathecin;RUBITECAN;RUBETICAN;Rubitecane;9-NITRO-CPT;9-Nitrocamptothecin;Rubitecan USP/EP/BP
- CBNumber
- CB9270138
- Molecular Formula
- C20H15N3O6
- Formula Weight
- 393.35
- MOL File
- 91421-42-0.mol
Rubitecan Property
- Melting point:
- 182-186°C
- alpha
- D23 +27° (c = 0.2 in CH3OH-CHCl3, 1:4)
- Boiling point:
- 816.3±65.0 °C(Predicted)
- Density
- 1.63
- Flash point:
- 106℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO, Chloroform, Methanol
- form
- Solid
- pka
- 11.16±0.20(Predicted)
- color
- Yellow
- Merck
- 14,8288
- CAS DataBase Reference
- 91421-42-0(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- RTECS
- UQ0493300
- HS Code
- 29399990
N-Bromosuccinimide Price
- Product number
- R3655
- Product name
- Rubitecan
- Packaging
- 10mg
- Price
- $56.7
- Updated
- 2024/03/01
- Product number
- R3655
- Product name
- Rubitecan
- Packaging
- 50mg
- Price
- $225
- Updated
- 2024/03/01
- Product number
- N0822
- Product name
- 9-Nitrocamptothecin
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $273
- Updated
- 2024/03/01
- Product number
- 28956
- Product name
- Rubitecan
- Packaging
- 10mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 28956
- Product name
- Rubitecan
- Packaging
- 25mg
- Price
- $112
- Updated
- 2024/03/01
Rubitecan Chemical Properties,Usage,Production
Description
Rubitecan, marketed by Supergen as Orathecin, is a promising oral treatment for solid melanoma, prostate, breast, ovarian, and other cancers, as well as leukemia. It is a derivative of camptothecin, a topoisomerase inhibitor known from Chinese Traditional Medicine. It selectively targets the critical S-stage of cellular reproduction – particularly in acidic environments, as in many cancer cells – relaxing DNA supercoiling and generating lethal breaks in the DNA. Due to insolubility, its biological delivery mechanism is not yet effective, and it has not been approved for clinical use.
Reference
https://www.sciencedirect.com/topics/medicine-and-dentistry/rubitecan
https://en.wikipedia.org/wiki/Rubitecan
https://en.wikipedia.org/wiki/Topoisomerase_inhibitor
https://en.wikipedia.org/wiki/Camptothecin#cite_note-Y.Pommier_2003-14
https://www.ncbi.nlm.nih.gov/pubmed/1995300
Description
Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner. Rubitecan inhibits the growth of A121 ovarian and H460 lung cancer cells (IC50s = 4 and 2 nM, respectively). It also inhibits the growth of doxorubicin-susceptible and -resistant MCF-7 breast cancer cells (IC50s = 2 and 3 nM, respectively). Rubitecan (4 mg/kg twice per week) reduces tumor growth in a U937 leukemia mouse xenograft model.
Chemical Properties
Yellow Amorphous Powder
Uses
Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic.
Definition
ChEBI: A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.
Rubitecan Preparation Products And Raw materials
Raw materials
Preparation Products
Rubitecan Suppliers
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- China
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- Country
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View Lastest Price from Rubitecan manufacturers
- Product
- Rubitecan 91421-42-0
- Price
- US $23.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2023-01-06
- Product
- Rubitecan 91421-42-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- Rubitecan 91421-42-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-02