tert-butyl 2-(3-broMophenyl)acetate
- Product Name
- tert-butyl 2-(3-broMophenyl)acetate
- CAS No.
- 197792-52-2
- Chemical Name
- tert-butyl 2-(3-broMophenyl)acetate
- Synonyms
- tert-butyl 2-(3-broMophenyl)acetate;Benzeneacetic acid, 3-bromo-, 1,1-dimethylethyl ester
- CBNumber
- CB92706129
- Molecular Formula
- C12H15BrO2
- Formula Weight
- 271.15
- MOL File
- 197792-52-2.mol
tert-butyl 2-(3-broMophenyl)acetate Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C12H15BrO2/c1-12(2,3)15-11(14)8-9-5-4-6-10(13)7-9/h4-7H,8H2,1-3H3
- InChIKey
- IUQYZZLJRJUKIH-UHFFFAOYSA-N
- SMILES
- C1(CC(OC(C)(C)C)=O)=CC=CC(Br)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 6003DL
- Product name
- Tert-butyl2-(3-bromophenyl)acetate
- Packaging
- 2.5g
- Price
- $266
- Updated
- 2021/12/16
- Product number
- 6003DL
- Product name
- Tert-butyl2-(3-bromophenyl)acetate
- Packaging
- 10g
- Price
- $680
- Updated
- 2021/12/16
- Product number
- A213991
- Product name
- tert-Butyl2-(3-bromophenyl)acetate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $22
- Updated
- 2021/12/16
- Product number
- A213991
- Product name
- tert-Butyl2-(3-bromophenyl)acetate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $33
- Updated
- 2021/12/16
- Product number
- A213991
- Product name
- tert-Butyl2-(3-bromophenyl)acetate
- Purity
- 95%
- Packaging
- 1g
- Price
- $79
- Updated
- 2021/12/16
tert-butyl 2-(3-broMophenyl)acetate Chemical Properties,Usage,Production
Synthesis
1694-31-1
591-18-4
197792-52-2
General procedure for the synthesis of tert-butyl 2-(3-bromophenyl)acetate: 1-bromo-3-iodobenzene (1.0 mmol), CuI (9.5 mg, 0.05 mmol), 2-pyridinecarboxylic acid (12 mg, 0.10 mmol), and cesium carbonate (978 mg, 3.0 mmol) were added to a Schlenk tube. The reaction tube was evacuated and displaced three times with argon, followed by the addition of tert-butyl acetoacetate (2.0 mmol) and 1,4-dioxane (2 mL). The reaction tube was placed in an oil bath and the reaction mixture was stirred at the indicated temperature for 33-48 hours. After completion of the reaction, the mixture was cooled and partitioned with ethyl acetate and saturated NH4Cl solution. The organic layer was separated, washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent petroleum ether/ethyl acetate (20:1 to 3:1) to afford the target product tert-butyl 2-(3-bromophenyl)acetate.
References
[1] Tetrahedron, 2014, vol. 70, # 20, p. 3327 - 3332
tert-butyl 2-(3-broMophenyl)acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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