KPT-330, (E)-RN

Product Name: KPT-330, (E)-RN
CAS No.: 1421923-86-5
Chemical Name: KPT-330, (E)-RN
Synonyms: (E)-KPT330;Kpt-330, (E)-;KPT-330, (E)-RN;Selinexor E-isomer;Selinexor trans-isomer;KPT-330,(E)-,KPT330,(E);SELINEXOR;KPT-330; (E)-RN;KPT330,(E)-, 10 mM in DMSO;Cariprazine Impurity 30 Hydrochloride;(E)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyrazin-2-ylprop-2-enehydrazide
CBNumber: CB92716546
Molecular Formula: C17H11F6N7O
Formula Weight: 443.31
MOL File: 1421923-86-5.mol

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KPT-330, (E)-RN Property

Density: 1.55±0.1 g/cm3(Predicted)
solubility: DMSO: Soluble
pka: 9.74±0.43(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ark Pharm

Product number: P000111055
Product name: (E)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide
Purity: 95+%
Packaging: 100mg
Price: $258
Updated: 2021/12/16

Ark Pharm

Product number: P000111055
Product name: (E)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide
Purity: 95+%
Packaging: 250mg
Price: $386
Updated: 2021/12/16

Crysdot

Product number: CD11260232
Product name: (E)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide
Purity: 95+%
Packaging: 100mg
Price: $282
Updated: 2021/12/16

Crysdot

Product number: CD11260232
Product name: (E)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide
Purity: 95+%
Packaging: 250mg
Price: $452
Updated: 2021/12/16

Alichem

Product number: 1421923865
Product name: (E)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide
Packaging: 250mg
Price: $506.16
Updated: 2021/12/16

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KPT-330, (E)-RN Chemical Properties,Usage,Production

Uses

KPT-330 is an orally bioavailable selective?Chromosome Region Maintenance (CRM1)?inhibitor, that has been shown to block pancreatic cancer cell proliferation and reduce tumor growth in mice.

Synthesis

1421923-96-7

54608-52-5

1421923-86-5

General procedure for the synthesis of (E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylhydrazide from the compound (CAS: 1421923-96-7) and pyrazin-2-hydrazine: 1. a solution was prepared by dissolving (E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid (0.75 g) in EtOAc (25 mL) and THF (12.5 mL). 2. To the above solution, a solution of 2-hydrazinopyrazine (0.23 g) in THF (12 mL) was added dropwise at room temperature. 3. Subsequently, T3P (50% ethyl acetate solution, 1.52 mL) and DIPEA (1.46 mL) were added dropwise and the reaction mixture was stirred at room temperature for 30 minutes. 4. After completion of the reaction, the reaction was quenched with ice-cold water and extracted with EtOAc (3 x 25 mL). 5. The organic layers were combined, washed with brine and dried over anhydrous Na2SO4. 6. concentrated under reduced pressure (35 °C, 20 mmHg) to give 0.698 g of crude product. 7. The crude product was first ground with petroleum ether and then with Et2O to give 275 mg (yield: 29%) of the target compound. Product characterization: 1H NMR (400 MHz, DMSO-d6) δ: 10.3 (s, 1H), 9.15 (s, 2H), 8.59 (s, 2H), 8.30-8.26 (d, J = 14.8 Hz, 1H), 8.13 (s, 1H), 8.06-8.07 (m, 1H), 6.98-6.95 (d, J = 13.4 Hz. 1H); LCMS for C17H12F6N7O [M + H]+: 443.31; found: 444.19 (retention time: 2.625 min, purity: 99.06%).

References

[1] Patent: WO2013/19548, 2013, A1. Location in patent: Page/Page column 71-72
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.

KPT-330, (E)-RN Preparation Products And Raw materials

Raw materials

Preparation Products

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KPT-330, (E)-RN Suppliers

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1421923-86-5, KPT-330, (E)-RNRelated Search:

Selinexor PD 173074 (Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3- Verdinexor (KPT-335)

KPT-330, (E)-RN

SELINEXOR;KPT-330; (E)-RN

Kpt-330, (E)-

KPT-330, (E)-RN (E)-3-(3-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-1H-1,2,4-TRIAZOL-1-YL)-N'-(PYRAZIN-2-YL)ACRYLOHYDRAZIDE

(E)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyrazin-2-ylprop-2-enehydrazide

Selinexor E-isomer

Selinexor trans-isomer

2-Propenoic acid, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide, (2E)-

KPT-330,(E)-,KPT330,(E)

(E)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide

Cariprazine Impurity 30 Hydrochloride

(E)-KPT330

KPT330,(E)-, 10 mM in DMSO

1421923-86-5

Inhibitors