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ChemicalBook > CAS DataBase List > MHY1485

MHY1485

Background
Product Name
MHY1485
CAS No.
326914-06-1
Chemical Name
MHY1485
Synonyms
MHY1485;MHY1485 ，S7811;MHY-1485;MHY 1485;MHY1485 USP/EP/BP;MHY1485, 10 mM in DMSO;mTOR Activator, MHY1485;4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine;4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine;1,3,5-Triazin-2-amine, 4,6-di-4-morpholinyl-N-(4-nitrophenyl)-;4,6-Bis(morpholin-4-yl)-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
CBNumber
CB92737150
Molecular Formula
C17H21N7O4
Formula Weight
387.39
MOL File
326914-06-1.mol
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MHY1485 Property

Melting point:
256-259 °C
Boiling point:
643.3±65.0 °C(Predicted)
Density 
1.415±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble2mg/mL, clear (warmed)
pka
6.19±0.10(Predicted)
form 
powder
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
InChI
InChI=1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21)
InChIKey
MSSXBKQZZINCRI-UHFFFAOYSA-N
SMILES
N1=C(N2CCOCC2)N=C(N2CCOCC2)N=C1NC1=CC=C([N+]([O-])=O)C=C1
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Safety

WGK Germany 
3
HS Code 
2934.99.3900
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0810
Product name
MHY 1485
Purity
≥95% (HPLC)
Packaging
5mg
Price
$81.1
Updated
2026/03/19
Sigma-Aldrich
Product number
SML0810
Product name
MHY 1485
Purity
≥95% (HPLC)
Packaging
25mg
Price
$328
Updated
2026/03/19
Sigma-Aldrich
Product number
5.00554
Product name
mTOR Activator, MHY1485
Packaging
10 mg
Price
$227
Updated
2026/03/19
TCI Chemical
Product number
M3107
Product name
MHY 1485
Purity
>95.0%(HPLC)
Packaging
25mg
Price
$146
Updated
2026/03/19
TCI Chemical
Product number
M3107
Product name
MHY 1485
Purity
>95.0%(HPLC)
Packaging
100mg
Price
$401
Updated
2026/03/19
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MHY1485 Chemical Properties,Usage,Production

Description

MHY1485 is a cell-permeable activator of mTOR that has been shown to increase levels of cellular mTOR Ser2448 and downstream substrate 4E-BP Thr37/46 phosphorylation in rat liver Ac2F cells. It can induce cellular LC3-II accumulation in Ac2F cells and has been shown to inhibit autophagy by suppressing the fusion between autophagosomes and lysosomes.

Uses

MHY1485 has been used:

  • to study the effect of mammalian target of rapamycin mTOR signalling on in vitro O-GlcNAcylation
  • to inhibit autophagy
  • as a mTOR agonist to demonstrate that the O-linked N-acetylglucosamine transferase- RNA helicase p68 (OGT-DDX5) axis regulates colorectal cancer cell proliferation and metastasis

Biochem/physiol Actions

MHY1485 is mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.

in vivo

MHY1485 (intraperitoneal injection; 10mg/kg, 2 days) blocks the autophagy signaling induced by follicle-stimulating hormone (FSH). It increases p-mTOR and p-S6K1 expression levels, whereas LC3 expression shows no marked change compared to that in the control group[3].

Animal Model:4-week-old female ICR mice[3]
Dosage:10mg/kg, 2 days
Administration:Intraperitoneal injection
Result:Suppressed the autophagy level following FSH treatment.

IC 50

mTORC1; mTORC2; Autophagy

Background

MHY1485 is a small, synthetic compound that activates the molecular mammalian target of rapamycin. mTOR is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. Cellular mTOR is a core component of both mTORC1 and mTORC2 multiprotein complexes, which regulate cell growth, proliferation, motility, and survival, as well as transcription, protein synthesis, and autophagy. Treatment of rat hepatocytes with MHY1485 suppressed autophagy by activating mTOR and inhibiting the fusion of autophagosomes and lysosomes. MHY1485 activated the mTOR-Nrf2 signaling pathway in UV-treated skin cells, preventing cell death and apoptosis. The mTOR activator suppressed UV-induced reactive oxygen species production and DNA single-strand breaks in UV-treated skin keratinocytes and fibroblasts. Similar treatment with MHY1485 rescued cultured osteoblasts from the cytotoxic effects of dexamethasone exposure, and increased ovarian weights, restored endocrine function, and promoted primordial follicle development in mice.

References

[1] YEON JA CHOI. Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion.[J]. PLoS ONE, 2012: e43418. DOI:10.1371/journal.pone.0043418
[2] YUAN CHENG. Promotion of ovarian follicle growth following mTOR activation: synergistic effects of AKT stimulators.[J]. PLoS ONE, 2015: e0117769. DOI:10.1371/journal.pone.0117769
[3] SAI ZHAO . MHY1485 activates mTOR and protects osteoblasts from dexamethasone[J]. Biochemical and biophysical research communications, 2016, 481 3: Pages 212-218. DOI:10.1016/j.bbrc.2016.10.104
[4] BO YANG. MHY1485 ameliorates UV-induced skin cell damages via activating mTOR-Nrf2 signaling[J]. Oncotarget, 2017, 8 1: 12775-12783. DOI:10.18632/oncotarget.14299
[5] CAIXIA LI  Helmy M S. (Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose.[J]. American journal of physiology. Endocrinology and metabolism, 2015, 309 3: E302-10. DOI:10.1152/ajpendo.00603.2014

MHY1485 Preparation Products And Raw materials

Raw materials

Preparation Products

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MHY1485 Suppliers

Americas 1 China 142 Europe 1 India 2 Japan 1 The Netherlands 1 United Kingdom 1 United States 16 Global 165
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
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55
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
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61
Adamas Reagent, Ltd.
Tel
400-6009262 15618770481
Fax
021-64823266
Email
yhx@titansci.com
Country
China
ProdList
14101
Advantage
59
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4790
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17714375163
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19906
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
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View Lastest Price from MHY1485 manufacturers

Career Henan Chemical Co
Product
4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine 326914-06-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20kg
Release date
2019-09-05

326914-06-1, MHY1485Related Search:

6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE MIF Antagonist, ISO-1 Chloroquine diphosphate Thapsigargin

  • MHY1485
  • 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
  • 4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
  • MHY-1485;MHY 1485
  • 1,3,5-Triazin-2-amine, 4,6-di-4-morpholinyl-N-(4-nitrophenyl)-
  • 4,6-Bis(morpholin-4-yl)-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
  • MHY1485 USP/EP/BP
  • MHY1485, 10 mM in DMSO
  • mTOR Activator, MHY1485
  • MHY1485 ，S7811
  • 326914-06-1
  • C17H21N7O4
  • Inhibitors