GSK-LSD1

Product Name: GSK-LSD1
CAS No.: 1431368-48-7
Chemical Name: GSK-LSD1
Synonyms: GSK-LSD1 2HCl;CS-1628;GSK-LSD;GSK-LSD1;GSK-LSD1 HC'k;GSKLSD1 GSK LSD1;GSK-LSD1(LSD1inhibitor);GSK-LSD1 2hydrochloride;GSK-LSD1 2HCl USP/EP/BP;GSK-LSD1 (trans-racemic)
CBNumber: CB92738768
Molecular Formula: C14H20N2
Formula Weight: 216.32
MOL File: 1431368-48-7.mol

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GSK-LSD1 Property

Boiling point:: 347.4±42.0 °C(Predicted)
Density: 1.07±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: H2O: soluble20mg/mL, clear
form: powder
pka: 10.14±0.10(Predicted)
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1072
Product name: GSK-LSD1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $115
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1072
Product name: GSK-LSD1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $462
Updated: 2024/03/01

Tocris

Product number: 5361
Product name: GSKLSD1dihydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $181
Updated: 2021/12/16

TRC

Product number: G797570
Product name: GSKLSD1Dihydrochloride
Packaging: 5mg
Price: $70
Updated: 2021/12/16

TRC

Product number: G797570
Product name: GSKLSD1Dihydrochloride
Packaging: 10mg
Price: $125
Updated: 2021/12/16

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GSK-LSD1 Chemical Properties,Usage,Production

Uses

GSK LSD1 Dihydrochloride is an irreversible mechanism-based inhibitor of LSD1. Lysine-specific demthylase 1 (LSD1) belonges to the flavin adenine dinucleotide (FAD) family-dependant amine oxidases that include MAOs and PAOs. Inhibits cell proliferation in cancer cell lines.

Uses

GSK-LSD1 has been used as a lysine specific demethylase 1 (LSD1) inhibitor in mice to study sepsis-induced mortality. It has also been used as an inhibitor to study if the effect of phenelzine activation of human immunodeficiency virus (HIV) latency is caused due to LSD1.

Biochem/physiol Actions

GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns. For full characterization details, please visit the GSK-LSD1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

References

[1]. structural genomics consortium.http://www. thesgc.org/chemical-probes/lsd1.

GSK-LSD1 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-LSD1 Suppliers

China 51 The Netherlands 1 United States 11 Global 63

Axon Medchem BV

Tel: --
Fax: --
Email: info@axonmedchem.com
Country: The Netherlands
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Advantage: 30

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N-[(1R,2S)-2-phenylcyclopropyl]piperidin-4-amine

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rel-N-[(1R,2S)-2-Phenylcyclopropyl]-4-piperidinamine

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GSK-LSD1 dihydrochloride(GSK-LSD1 2HCl)

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N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine dihydrochloride

GSK-LSD1 (trans-racemic) dihydrochloride

rel- N-[(1R,2S)-2-Phenylcyclopropyl]-4-Piperidinamine hydrochloride (1:2)

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4-Piperidinamine, N-[(1R,2S)-2-phenylcyclopropyl]-, rel-

GSK-LSD1 2HCl USP/EP/BP

GSK-LSD1

1431368-48-7

Inhibitors