Anti-Prostate differentiation factor
- Product Name
- Anti-Prostate differentiation factor
- Chemical Name
- Anti-Prostate differentiation factor
- Synonyms
- MIC1;GDF-15;C18orf8;HsT2591;FLJ23453;Anti-PDF;Anti-PLAB;Anti-MIC-1;Anti-NAG-1;Anti-NRG-1
- CBNumber
- CB92879564
- Formula Weight
- 0
- MOL File
- Mol file
Anti-Prostate differentiation factor Property
- storage temp.
- -20°C
- form
- buffered aqueous solution
- biological source
- rabbit
N-Bromosuccinimide Price
- Product number
- SAB4503655
- Product name
- Anti-GDF15 antibody produced in rabbit
- Purity
- affinity isolated antibody
- Packaging
- 100μG
- Price
- $522
- Updated
- 2025/07/31
- Product number
- SAB2501825
- Product name
- Anti-C18orf8 antibody produced in goat
- Purity
- affinity isolated antibody, buffered aqueous solution
- Packaging
- 100μG
- Price
- $586
- Updated
- 2025/07/31
- Product number
- SAB1300851
- Product name
- Anti-MIC1 (center) antibody produced in rabbit
- Purity
- saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution
- Packaging
- 100μG
- Price
- $455
- Updated
- 2025/07/31
- Product number
- HPA070957
- Product name
- Anti-GDF15 antibody produced in rabbit
- Purity
- Prestige Antibodies<SUP>®</SUP> Powered by Atlas Antibodies, affinity isolated antibody
- Packaging
- 100 μL
- Price
- $530
- Updated
- 2025/07/31
- Product number
- HPA043589
- Product name
- Anti-C18ORF8 antibody produced in rabbit
- Purity
- Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
- Packaging
- 100μL
- Price
- $555
- Updated
- 2025/07/31
Anti-Prostate differentiation factor Chemical Properties,Usage,Production
Uses
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .
General Description
GDF15 (growth differentiation factor 15) is a part of the transforming growth factor-β (TGFβ) or bone morphogenetic protein (BMP) superfamily. This gene resides in human chromosomal locus 19p12.1-13.1, and contains two exons. The pro-protein is a dimer containing a disulfide linkage which undergoes cleavage at RXXR sequence, by furin-like protease. The mature protein is a C-terminal dimer composed of 112 amino acids.
Biochem/physiol Actions
GDF15 (growth differentiation factor 15) is released in response to stress such as, inflammation, oxidative stress and hypoxia, from multiple tissues, such as heart and liver. Studies show that it is responsible for the down-regulation of microRNAs of muscles, leading to intensive care unit-acquired weakness (ICUAW) and related muscle atrophy. It also controls the developmental processes underlying embryogenesis, osteogenesis, and hematopoiesis. It also regulates adipose tissue function, cartilage and bone synthesis and immune response. It is involved in tissue injury and repair processes. It is up-regulated in melanoma, thyroid, breast, pancreatic, gastrointestinal, prostate and colorectal cancer. It is involved in tumorigenesis, and abnormal expression is related to poor prognosis in various cancers. It is a biomarker for multiple epithelial cancers such as, renal cell carcinoma, adenocarcinoma of the esophagus, ovary and colon. In glioblastomas, it acts as a tumor suppressor gene and induces apoptosis.
Anti-Prostate differentiation factor Preparation Products And Raw materials
Raw materials
Preparation Products
Anti-Prostate differentiation factor Suppliers
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