TILUDRONIC ACID, DISODIUM SALT

Product Name: TILUDRONIC ACID, DISODIUM SALT
CAS No.: 149845-07-8
Chemical Name: TILUDRONIC ACID, DISODIUM SALT
Synonyms: SKELID;SR-41319B;SR 41319G;Unii-bh6m93cia0;Tiludrote disodium;DisodiuM Tiludronate;DisodiumTiludronate>TILUDRONIC ACID, DISODIUM SALT;Disodium (4-chlorophenylthio)methylenediphosphonate;(((4-chlorophenyl)thio)methylene)diphosphonic acid, sodium salt
CBNumber: CB9288177
Molecular Formula: C7H10ClNaO6P2S
Formula Weight: 342.6
MOL File: 149845-07-8.mol

More

Less

TILUDRONIC ACID, DISODIUM SALT Property

Melting point:: >300°C
storage temp.: -20°C Freezer
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
Merck: 14,9441

More

Less

Safety

HS Code: 2931.39.0030

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: D4167
Product name: Disodium Tiludronate
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $290
Updated: 2024/03/01

TRC

Product number: T441250
Product name: TiludronicAcidDisodiumSalt
Packaging: 250mg
Price: $400
Updated: 2021/12/16

Usbiological

Product number: T5468
Product name: Tiludronic Acid, Disodium Salt
Packaging: 100mg
Price: $432
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT28278
Product name: Tiludronic acid disodium salt
Packaging: 250mg
Price: $625
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0004187
Product name: TILUDRONIC ACID DISODIUM SALT
Purity: 95.00%
Packaging: 100MG
Price: $727.65
Updated: 2021/12/16

More

Less

TILUDRONIC ACID, DISODIUM SALT Chemical Properties,Usage,Production

Description

Tiludronate disodium, the first of the third generation of bisphosphonates, was introduced to the market in Switzerland for the treatment of Paget‘s disease. Bisphosphonates have high affinity for bone. When given orally, they are not metabolized but are absorbed, stored, preferentially localized to the skeleton where they inhibit bone resorption and therefore are useful in the treatment of diseases of high bone turnover such as Paget’s disease and hypercalcemia of malignancy. Mechanistically, tiludronate disodium is suggested to be a specific inhibitor of functioning osteoclasts through selective incorporation into the polarized osteoclastlike multinucleated cells and direct interference with the maintenance of the cytoskeletal structure. Tiludronate disodium is reportedly in clinical trials for osteoporosis in post-menopausal women.

Chemical Properties

Fine White to Off-White Crystalline Powder

Originator

Sanofi (France)

Uses

A biphosphonate bone resorption inhibitor.

Manufacturing Process

The 50% strength suspension of sodium hydride in oil is added, a little at a time to a solution of tetraisopropyl methylene-diphosphonate in dimethylformamide. After all has been added, the mixture is stirred, the 1-(4- chlorphenyl) disulfide is then added and the whole is heated at 25°C for 6 h. The mixture is evaporated to dryness in vacuo and residue is taken up in hexane. The solution is washed with water and dried. The solvent is evaporated to dryness and the residue is chromatographed on silica column, elution being carried out with a 98:2 (v/v) mixture of methylene chloride/methanol. The obtained 1-(4-chlorphenylthio)tetraisopropyl methylene-diphosphonate is then hydrolyzed with 12 N HCl for 18 h to give the 1-(4-chlorphenylthio)methylene-diphosphonic acid.
The 1-(4-chlorphenylthio)methylene-diphosphonic acid are dissolved in water, containing sodium hydroxide. The solution is filtered, the methanol are then added and the mixture is left to crystallize. The precipitate is filtered off and washed with methanol and dried at 80°C in vacuo and the disodium salt of 1- (4-chlorphenylthio)methylene-diphosphonic acid is thus obtained.

brand name

Skelid

Therapeutic Function

Bone calcium regulator

Biological Activity

Tiludronate (Tiludronic Acid) disodium is an orally active bisphosphonate that acts as a bone modulating agent. Tiludronate disodium for the study of metabolic bone diseases. Tiludronate disodium is a potent inhibitor of osteoclast vacuolar H(+)-ATPase.

in vitro

The ability of Tiludronate to inhibit proton transport is 5-fold higher in kidney-derived vesicles (IC 50 =1.1 mM) and 10,000-fold higher in vesicles derived from osteoclasts (IC 50 =466 nM). Tiludronate also potently inhibits proton transport in yeast microsomal preparations (IC 50 =3.5 microM) and inhibits the activity of purified yeast V-ATPase. The inhibition of the osteoclast V-ATPase-mediated proton transport by Tiludronate is rapid, pH-dependent, and reversible.

in vivo

Tiludronate exerts a dose-dependent inhibitory activity on bone resorption. Tiludronate could act on mature osteoclasts by reducing their capacity to secrete proton into the resorption space and also by favoring their detachment from the bone matrix. Tiludronate is also tested in other models of osteoporosis. In the castrated male rat model, Tiludronate (5-200 mg/kg; p.o.) prevents the decrease in the skeletal mass, assessed physically by measuring the bone weight and density or chemically by determining the calcium and phosphate content.

TILUDRONIC ACID, DISODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

TILUDRONIC ACID, DISODIUM SALT Suppliers

Americas 1 Canada 1 China 37 Europe 1 France 1 Germany 1 India 2 Japan 2 Switzerland 1 United Kingdom 3 United States 16 Global 66

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

Cato Research Chemicals Inc.

Tel: 020-81960175
Fax: +1-541-2553641
Email: min.he@cato-chem.com
Country: China
ProdList: 1955
Advantage: 55

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20806
Advantage: 60

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29764
Advantage: 68

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718 +86-13336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29793
Advantage: 60

Nanjing NingFan Pharm-Tech CO. LTD.

Tel: 17368696818
Country: China
ProdList: 1984
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57423
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52849
Advantage: 58

Guangdong Wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886766 13927870850
Fax: 0751-2886756
Email: 3001267247@qq.com
Country: China
ProdList: 9974
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49374
Advantage: 58

CHG Opto-Electronic Corporation Limited

Tel: 2537653158 16621191650
Fax: QQ 2537653158
Email: 2537653158@qq.com
Country: China
ProdList: 7116
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44806
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29976
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 15162312715
Email: sales@szzxbio.com
Country: China
ProdList: 2990
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

SHANGHAI KEAN TECHNOLOGY CO., LTD.

Tel: +8613817748580
Fax: 021-50175322
Email: cooperation@kean-chem.com
Country: China
ProdList: 40066
Advantage: 58

Shanghai Acmec Biochemical Technology Co., Ltd.

Tel: +undefined18621343501
Email: product@acmec-e.com
Country: China
ProdList: 33338
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 49977
Advantage: 58

PT CHEM GROUP LIMITED

Tel: +86-85511178; +86-85511178;
Email: peter68@ptchemgroup.com
Country: China
ProdList: 35425
Advantage: 58

Shanghai Han-Xiang Chemical Co., Ltd.

Tel: --
Fax: --
Email: kexianxun@gmail.com
Country: China
ProdList: 1037
Advantage: 50

Shanghai Ziqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 2453006496@qq.com
Country: CHINA
ProdList: 6184
Advantage: 58

Shanghai Yubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 344843571@qq.com
Country: CHINA
ProdList: 6318
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Xiamen Research Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1562893815@qq.com
Country: CHINA
ProdList: 6936
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6906
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6973
Advantage: 58

Tractus Company Limited

Tel: --
Fax: --
Email: contact@tractuschem.com
Country: China
ProdList: 282
Advantage: 60

Shanghai Yare Biotech, Inc.

Tel: --
Fax: --
Email: sales@yarebio.cn
Country: China
ProdList: 317
Advantage: 50

Advanced Technology & Industrial Co., Ltd.

Tel: --
Fax: --
Email: sales@advtechind.com
Country: China
ProdList: 6523
Advantage: 75

149845-07-8, TILUDRONIC ACID, DISODIUM SALTRelated Search:

1,4-PHENYLENE DIISOTHIOCYANATE Benzenesulfonic acid Vitamin D2 Tiludronic acid TILUDRONIC ACID, DISODIUM SALT METHYLENEBISPHOSPHONIC ACID-P,P'-DISODIUM SALT

Disodium (4-chlorophenylthio)methylenediphosphonate

SR-41319B

SKELID

TILUDRONIC ACID, DISODIUM SALT

[[(4-CHLOROPHENYL)THIO]METHYLENE]BIPHOSPHONIC ACID, DISODIUM SALT

[[(4-Chlorophenyl)thio]methylene]biphosphonicAcid,DisodiumSalt,SR-41319B,Skelid

Unii-bh6m93cia0

DisodiuM Tiludronate

SR 41319G

DisodiumTiludronate&gt

Tiludrote disodium

Disodium [[(4-Chlorophenyl)thio]methylene]bis(hydrogenphosphonate)

(((4-chlorophenyl)thio)methylene)diphosphonic acid, sodium salt

149845-07-8

C7H7ClNa2O6P2S

Intermediates & Fine Chemicals

Pharmaceuticals

Phosphorylating and Phosphitylating Agents